Fed-batch culture of recombinant NSO myeloma cells with high monoclonal antibody production

Biotechnology and Bioengineering

Volumn 55, Issue 5, 1997, Pages 783-792

  Zhou, Weichang ^a   Chen, Chun Chiang ^a   Buckland, Barry ^a   Aunins, John ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Cellular metabolism; Fed batch culture; Glutamine synthetase; Humanized monoclonal antibody; Lactate consumption; NSO myeloma cells

Indexed keywords

BIOTECHNOLOGY; ENZYMES; GROWTH KINETICS; METABOLISM; MONOCLONAL ANTIBODIES;

CELLULAR METABOLISM; FED BATCH CULTURE; HUMANIZED MONOCLONAL ANTIBODY; LACTATE CONSUMPTION; MYELOMA CELLS; OXYGEN UPTAKE RATE;

BATCH CELL CULTURE;

AMMONIA; CD18 ANTIGEN; GLUCOSE; GLUTAMATE AMMONIA LIGASE; GLUTAMIC ACID; GLUTAMINE; LACTIC ACID; MONOCLONAL ANTIBODY; OXYGEN; PYRUVIC ACID;

ANIMAL CELL; ANTIBODY PRODUCTION; ARTICLE; CELL CULTURE; CELL DEATH; CELL GROWTH; CELL METABOLISM; CONTROLLED STUDY; FEEDING; MOUSE; MYELOMA CELL; NONHUMAN; NUTRIENT;

EID: 0031554884     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(19970905)55:5<783::AID-BIT8>3.0.CO;2-7     Document Type: Article

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