2-thioether 5'-O-(1-thiotriphosphate)adenosine derivatives as new insulin secretagogues acting through P2Y-receptors

Journal of Medicinal Chemistry

Volumn 42, Issue 18, 1999, Pages 3636-3646

  Fischer, Bilha ^a   Chulkin, Ana ^a   Boyer, Jose L ^b   Harden, Kendall T ^b   Gendron, Fernand Pierre ^d   Beaudoin, Adrien R ^d   Chapal, Jeannie ^c   Hillaire Buys, Dominique ^c   Petit, Pierre ^c  

^a BAR ILAN UNIVERSITY   (Israel)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c UNIV MONTPELLIER   (France)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

2 (6 AMINO 2 HEXYLSULFANYL 7H PURIN 9 YL) 5 O (1 THIOTRIPHOSPHATE METHYL)TETRAHYDROFURAN 3,4 DIOL; 2 THIOETHER 5' O (1 THIOTRIPHOSPHATE)ADENOSINE DERIVATIVE; ADENOSINE DERIVATIVE; PURINE P2 RECEPTOR; UNCLASSIFIED DRUG;

AGONIST; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CHIRALITY; CONCENTRATION (PARAMETERS); DIASTEREOISOMER; DRUG DISCRIMINATION; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ENZYME INHIBITION; ERYTHROCYTE MEMBRANE; HYDROLYSIS; INSULIN RELEASE; NONHUMAN; PANCREAS FUNCTION; PROTEIN STABILITY; RAT; TURKEY (BIRD);

ADENOSINE; ADENOSINE TRIPHOSPHATE; ANIMALS; APYRASE; ENZYME STABILITY; INSULIN; ISLETS OF LANGERHANS; KINETICS; NUCLEOTIDES; PANCREAS; RECEPTORS, PURINERGIC P2; SULFIDES; SWINE; THIONUCLEOTIDES;

EID: 0033539109     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990158y     Document Type: Article

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