Dissecting the structural and functional roles of the S3-S4 linker of pacemaker (hyperpolarization-activated cyclic nucleotide-modulated) channels by systematic length alterations

Journal of Biological Chemistry

Volumn 279, Issue 42, 2004, Pages 43752-43759

  Suk, Ying Tsang ^a,b   Lesso, Heinte ^a   Li, Ronald A ^c,d  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Croucher Foundation   (Hong Kong)

^c Cardiac Arrhythmias Res Educ F   (United States)

^d JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HELICAL STRUCTURES; HYPERPOLARIZATIONS; LINKERS; PHENOTYPES;

ACTIVATION ANALYSIS; CARDIOLOGY; CELLS; GENES;

PACEMAKERS;

GLUTAMINE; ION CHANNEL; METHIONINE; NUCLEOTIDE; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DEPOLARIZATION; ELECTRIC CURRENT; GENE; GENE DELETION; HYPERPOLARIZATION; MULTIGENE FAMILY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; STEADY STATE; STRUCTURE ANALYSIS; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; ION CHANNELS; KINETICS; MEMBRANE POTENTIALS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NERVE TISSUE PROTEINS; PEPTIDE FRAGMENTS; POLYMERASE CHAIN REACTION; PROTEIN CONFORMATION; RECOMBINANT FUSION PROTEINS; SEQUENCE DELETION;

ANIMALIA; INSERTION SEQUENCES;

EID: 6344255128     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M408747200     Document Type: Article

References (22)

1. DiFrancesco, D. (1993) Annu. Rev. Physiol. 55, 455-472
2. Pape, H. C. (1996) Annu. Rev. Physiol. 58, 299-327
3. Gauss, R., Seifert, R., and Kaupp, U. B. (1998) Nature 393, 583-587
4. Ludwig, A., Zong, X., Jeglitsch, M., Hofmann, F., and Biel, M. (1998) Nature 393, 587-591
5. Santoro, B., Liu, D. T., Yao, H., Bartsch, D., Kandel, E. R., Siegelbaum, S. A., and Tibbs, G. R. (1998) Cell 93, 717-729
6. Xue, T., Marban, E., and Li, R. A. (2002) Circ. Res. 90, 1267-1273
7. Xue, T., and Li, R. A. (2002) J. Biol. Chem. 277, 46233-46242
8. Männikkö, R., Elinder, F., and Larsson, H. P. (2002) Nature 419, 837-841
9. Vemana, S., Pandey, S., and Larsson, H. P. (2004) J. Gen. Physiol. 123, 21-32
10. Mathur, R., Zheng, J., Yan, Y., and Sigworth, F. J. (1997) J. Gen. Physiol. 109, 191-199
11. Gonzalez, C., Rosenman, E., Bezanilla, F., Alvarez, O., and Latorre, R. (2000) J. Gen. Physiol. 115, 193-208
12. Gonzalez, C., Rosenman, E., Bezanilla, F., Alvarez, O., and Latorre, R. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 9617-9623
13. Henrikson, C. A., Xue, T., Dong, F., Sang, D., Marban, E., and Li, R. A. (2003) J. Biol. Chem. 278, 13647-13654
14. Lesso, H., and Li, R. A. (2003) J. Biol. Chem. 278, 22290-22297
15. Tsang, S. Y., Lesso, H., and Li, R. A. (2004) Biophys. J. 86, 293a
16. Jiang, Y., Ruta, V., Chen, J., Lee, A., and MacKinnon, R. (2003) Nature 423, 42-48
17. Nakai, J., Adams, B. A., Imoto, K., and Beam, K. G. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 1014-1018
18. Catterall, W. A. (1986) Annu. Rev. Biochem. 55, 953-985
19. Durell, S. R., and Guy, H. R. (1992) Biophys. J. 1, 1-14
20. Azene, E. M., Xue, T., and Li, R. A. (2003) J. Physiol. 547, 349-356
21. Sørensen, J. B., Cha, A., Latorre, R., Rosenman, E., and Bezanilla, F. (2000) J. Gen. Physiol. 115, 209-222
22. Xue, T., Chan, C. W. Y., Henrikson, C. A., Sang, D., Marban, E., and Li, R. A. (2003) Circulation 108, 4-33