Deletion of the GABAA receptor α1 subunit increases tonic GABAA receptor current: A role for GABA uptake transporters

Journal of Neuroscience

Volumn 26, Issue 36, 2006, Pages 9323-9331

  Ortinski, Pavel I ^a   Turner, Jill R ^a   Barberis, Andrea ^b   Motamedi, Gholam ^a   Yasuda, Robert P ^a   Wolfe, Barry B ^a   Kellar, Kenneth J ^a   Vicini, Stefano ^a  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

1; GABA transporter; GABAA; Knock out; Patch clamp; Tonic inhibition

Indexed keywords

1 [2 (BENZHYDRYLIDENEAMINOOXY)ETHYL] 1,2,5,6 TETRAHYDRO 3 PYRIDINECARBOXYLIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1 SUBUNIT; GABOXADOL; PROTEIN; PROTEIN GABA TRANSPORTER 1; PROTEIN GABA TRANSPORTER 3; UNCLASSIFIED DRUG;

4 AMINOBUTYRIC ACID UPTAKE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CELL; CEREBELLUM; CONTROLLED STUDY; MOUSE; NERVE CELL EXCITABILITY; NEUROTRANSMITTER UPTAKE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BLOCKING;

ANIMALS; CELLS, CULTURED; CEREBELLUM; GABA PLASMA MEMBRANE TRANSPORT PROTEINS; GAMMA-AMINOBUTYRIC ACID; GENE DELETION; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURONS; PROTEIN SUBUNITS; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33748498941     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2610-06.2006     Document Type: Article

References (70)

1. A receptors of thalamocortical neurons: a molecular target for hypnotics. J Neurosci 25:11513-11520.
2. Bernstein EM, Quick MW (1999) Regulation of gamma-aminobutyric acid (GABA) transporters by extracellular GABA. J Biol Chem 274:889-895.
3. Brickley SG, Cull-Candy SG, Farrant M (1996) Development of a tonic form of synaptic inhibition in rat cerebellar granule cells resulting from persistent activation of GABAA receptors. J Physiol (Lond) 497:753-759.
4. Brickley SG, Revilla V, Cull-Candy SG, Wisden W, Farrant M (2001) Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance. Nature 409:88-92.
5. Brickley SG, Cull-Candy SG, Farrant M (2003) Vesicular release of GABA contributes to both phasic and tonic inhibition of granule cells in the mature cerebellum of mice. J Physiol (Lond) 547P:C30.
6. A receptors. Br J Pharmacol 136:965-974.
7. Chiu CS, Brickley S, Jensen K, Southwell A, Mckinney S, Cull-Candy S, Mody I, Lester HA (2005) GABA transporter deficiency causes tremor, ataxia, nervousness, and increased GABA-induced tonic conductance in cerebellum. J Neurosci 25:3234-3245.
8. A receptor-mediated tonic inhibition in thalamic neurons. J Neurosci 25:11553-11563.
9. A receptor subtype to the pharmacological actions of benzodiazepine site inverse agonists. Neuropharmacology 43:679-684.
10. A receptors. J Pharmacol Exp Ther 272:438-445.
11. During MJ, Ryder KM, Spencer DD (1995) Hippocampal GABA transporter function in temporal-lobe epilepsy. Nature 376:174-177.
12. Ebert B, Thompson SA, Saounatsou K, McKernan R, Krogsgaard-Larsen P, Wafford KA (1997) Differences in agonist/antagonist binding affinity and receptor transduction using recombinant human γ-aminobutyric acid type A receptors. Mol Pharmacol 52:1150-1156.
13. A receptors. Nat Rev Neurosci 6:215-229.
14. A receptor confer distinct channel gating kinetics. J Physiol (Lond) 561:433-448.
15. A receptors containing γ2 or δ subtypes expressed with α1 and β3 subtypes in mouse L929 cells. J Physiol (Lond) 505:283-297.
16. A-receptor subtypes during postnatal development: an immunohistochemical study. J Neurosci 14:5302-5324.
17. Fueta Y, Vasilets LA, Takeda K, Kawamura M, Schwarz W (2003) Downregulation of GABA-transporter function by hippocampal translation products: its possible role in epilepsy. Neuroscience 118:371-378.
18. Gaspary HL, Wang W, Richerson GB (1998) Carrier-mediated GABA release activates GABA receptors on hippocampal neurons. J Neurophysiol 80:270-281.
19. A receptor gating kinetics on the alpha-subunit isoform: implications for structure-function relations and synaptic transmission. J Physiol (Lond) 489:529-543.
20. Hamann M, Rossi DJ, Attwell D (2002) Tonic and spillover inhibition of granule cells control information flow through cerebellar cortex. Neuron 33:625-633.
21. A receptor activity. Nat Neurosci 8:339-345.
22. A receptor α1 subunit knock out mice. Neuroscience 122:699-705.
23. Hevers W, Luddens H (2002) Pharmacological heterogeneity of γ-aminobutyric acid receptors during development suggests distinct classes of rat cerebellar granule cells in situ. Neuropharmacology 42:34-47.
24. A receptor currents. J Neurosci 23:11698-11710.
25. Itouji A, Sakai N, Tanaka C, Saito N (1996) Neuronal and glial localization of two GABA transporters (GAT1 and GAT3) in the rat cerebellum. Brain Res Mol Brain Res 37:309-316.
26. A receptor α6 subunit gene inactivation inhibits δ subunit expression. J Neurosci 17:1350-1362.
27. A receptor phosphorylation, activity, and cell-surface stability. J Neurosci 24:522-530.
28. A receptor α1 subunit knockout mice. J Pharmacol Exp Ther 302:1037-1045.
29. Kralic JE, Criswell HE, Osterman JL, O'Buckley TK, Wilkie ME, Matthews DB, Hamre K, Breese GR, Homanics GE, Morrow AL (2005) Genetic essential tremor in γ-aminobutyric acidA receptor α1 subunit knockout mice. J Clin Invest 115:774-779.
30. Kralic JE, Sidler C, Parpan F, Homanics GE, Morrow AL, Fritschy JM (2006) Compensatory alteration of inhibitory synaptic circuits in cerebellum and thalamus of γ-aminobutyric acid type A receptor α1 subunit knockout mice. J Comp Neurol 495:408-421.
31. A receptor subunit mRNAs in the rat brain. II. Olfactory bulb and cerebellum. J Neurosci 12:1063-1076.
32. A receptor channels are dependent on alpha-subunit isoform. Biophys J 73:2518-2526.
33. Levi G, Raiteri M (1993) Carrier-mediated release of neurotransmitters. Trends Neurosci 16:415-419.
34. A receptors mediating tonic inhibition alter seizure susceptibility and anxiety. Nat Neurosci 8:797-804.
35. Mitchell SJ, Silver RA (2003) Shunting inhibition modulates neuronal gain during synaptic excitation. Neuron 38:433-445.
36. A receptors by hydrogen ions reveals synaptic GABA transient and a crucial role of the desensitization process. J Neurosci 23:7981-7992.
37. Murase K, Ryu PD, Randic M (1989) Excitatory and inhibitory amino acids and peptide-induced responses in acutely isolated rat spinal dorsal horn neurons. Neurosci Lett 103:56-63.
38. A receptors to synaptic and extrasynaptic membranes of cerebellar granule cells. J Neurosci 18:1693-1703.
39. A receptors by cAMP-dependent protein kinase in mouse cerebellar and olfactory bulb neurones. J Physiol (Lond) 521:421-435.
40. Ogris W, Lehner R, Fuchs K, Furtmuller B, Hoger H, Homanics GE, Sieghart W (2006) Investigation of the abundance and subunit composition of GABA receptor subtypes in the cerebellum of α1-subunit-deficient mice. J Neurochem 96:136-147.
41. A receptor regulates inhibitory synaptic strength. J Neurophysiol 92:1718-1727.
42. Patrylo PR, Spencer DD, Williamson A (2001) GABA uptake and heterotransport are impaired in the dentate gyrus of epileptic rats and humans with temporal lobe sclerosis. J Neurophysiol 85:1533-1542.
43. A receptors. J Neurosci 26:5673-5683.
44. Pow DV, Sullivan RK, Williams SM, Scott HL, Dodd PR, Finkelstein D (2005) Differential expression of the GABA transporters GAT-1 and GAT-3 in brains of rats, cats, monkeys and humans. Cell Tissue Res 320:379-392.
45. A receptor gating in cultured rat hippocampal neurons. Neuropharmacology 50:143-153.
46. Quick MW, Hu J, Wang D, Zhang HY (2004) Regulation of a γ-aminobutyric acid transporter by reciprocal tyrosine and serine phosphorylation. J Biol Chem 279:15961-15967.
47. A α1 subunit knock-out mice do not show a hyperlocomotor response following amphetamine or cocaine treatment. Neuropharmacology 44:190-198.
48. Richerson GB, Wu Y (2003) Dynamic equilibrium of neurotransmitter transporters: not just for reuptake anymore. J Neurophysiol 90:1363-1374.
49. Robinson MB (2002) Regulated trafficking of neurotransmitter transporters: common notes but different melodies. J Neurochem 80:1-11.
50. A receptors and glomerular geometry. Neuron 20:783-795.
51. Rossi DJ, Hamann M, Attwell D (2003) Multiple modes of GABAergic inhibition of rat cerebellar granule cells. J Physiol (Lond) 548:97-110.
52. A receptor function and dissection of the pharmacology of benzodiazepines and general anesthetics through mouse genetics. Annu Rev Pharmacol Toxicol 44:475-498.
53. A receptor subtypes. Nature 401:796-800.
54. Saxena NC, Macdonald RL (1994) Assembly of GABAA receptor subunits: role of the δ subunit. J Neurosci 14:7077-7086.
55. Saxena NC, Macdonald RL (1996) Properties of putative cerebellar γ-aminobutyric acid A receptor isoforms. Mol Pharmacol 49:567-579.
56. A receptor currents in the hippocampus. J Neurosci 25:10016-10024.
57. Semyanov A, Walker MC, Kullmann DM (2003) GABA uptake regulates cortical excitability via cell type-specific tonic inhibition. Nat Neurosci 6:484-490.
58. A receptors: modulating gain and maintaining the tone. Trends Neurosci 27:262-269.
59. Sigworth FJ, Sine SM (1987) Data transformations for improved display and fitting of single-channel dwell time histograms. Biophys J 52:1047-1054.
60. A receptor subtype in the brain is not lethal in mice. J Neurosci 21:3409-3418.
61. Sutch RJ, Davies CC, Bowery NG (1999) GABA release and uptake measured in crude synaptosomes from genetic absence epilepsy rats from Strasbourg (GAERS). Neurochem Int 34:415-425.
62. A receptor β2-α6-α1-γ2 subunit gene cluster. Mol Cell Neurosci 16:34-41.
63. A receptor in mice make inhibition exciting. Pharmacol Ther 103:109-120.
64. A receptor α1 subunit deletion prevents developmental changes of inhibitory synaptic currents in cerebellar neurons. J Neurosci 21:3009-3016.
65. Wadiche JI, Jahr CE (2005) Patterned expression of Purkinje cell glutamate transporters controls synaptic plasticity. Nat Neurosci 8:1329-1334.
66. A receptor occupancy occur during the postnatal development of rat Purkinje cell but not granule cell synapses. Neuropharmacology 49:596-609.
67. A receptor-mediated currents in granule cells of postnatal rat cerebellum. Eur J Neurosci 9:533-548.
68. A receptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon. J Neurosci 12:1040-1062.
69. Wu Y, Wang W, Richerson GB (2003) Vigabatrin induces tonic inhibition via GABA transporter reversal without increasing vesicular GABA release. J Neurophysiol 89:2021-2034.
70. --dependent neurotransmitter transporters: drugs, substrates, presynaptic receptors, and signaling systems. Pharmacol Ther 92:21-55.