Polyamine-modulated c-Myc expression in normal intestinal epithelial cells regulates p21Cip1 transcription through a proximal promoter region

Biochemical Journal

Volumn 398, Issue 2, 2006, Pages 257-267

  Liu, Lan ^a,b   Guo, Xin ^a,b   Rao, Jaladanki N ^a,b   Zou, Tongtong ^a,b   Marasa, Bernard S ^a   Chen, Jie ^a,b   Greenspon, Jose ^a   Casero Jr , Robert A ^c   Wang, Jian Ying ^a,b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b BALTIMORE VA MEDICAL CENTER   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

difluoromethylornithine (DFMO); Cell proliferation; Gene expression; Intestinal epithelium cell (IEC); Ornithine decarboxylase (ODC); Transcriptional repression

Indexed keywords

AMINES; ENZYME INHIBITION; ENZYMES; GENES; GENETIC ENGINEERING; MUTAGENESIS;

Α-DIFLUOROMETHYLORNITHINE (DFMO); CELL PROLIFERATION; GENE EXPRESSION; INTESTINAL EPITHELIUM CELL (IEC); ORNITHINE DECARBOXYLASE (ODC); TRANSCRIPTIONAL REPRESSION;

CELLS;

CYCLIN DEPENDENT KINASE INHIBITOR 1; EFLORNITHINE; MYC PROTEIN; ORNITHINE DECARBOXYLASE; POLYAMINE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; ENZYME INHIBITOR; MIZ1 PROTEIN, RAT; NUCLEAR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DEPLETION; DRUG INHIBITION; ENZYME ACTIVITY; EPITHELIUM CELL; GENE CONTROL; GENE EXPRESSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING; ANIMAL; BINDING SITE; CELL LINE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; INTESTINE; METABOLISM; MUTATION; PROMOTER REGION; RAT;

ANIMALS; BINDING SITES; CELL LINE; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; ENZYME INHIBITORS; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; HUMANS; INTESTINES; MUTATION; NUCLEAR PROTEINS; ORNITHINE DECARBOXYLASE; POLYAMINES; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-MYC; RATS; TRANSCRIPTION, GENETIC;

EID: 33748343207     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20060217     Document Type: Article

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