Modelling facets of mania - New directions related to the notion of endophenotypes

Journal of Psychopharmacology

Volumn 20, Issue 5, 2006, Pages 714-722

  Einat, Haim ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Animal models; Bipolar disorder; Endophenotypes; Facets of disease; Mania; Test battery; Validity

Indexed keywords

AGGRESSION; CONCENTRATION LOSS; DECISION MAKING; DISEASE MODEL; DISTRACTIBILITY; DRUG ABUSE; DRUG RESPONSE; HYPERACTIVITY; IRRITABILITY; LIBIDO; MANIA; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RESTLESSNESS; REVIEW; SLEEP; SLEEP DISORDER; VALIDITY;

AGGRESSION; ANIMALS; ATTENTION; BIPOLAR DISORDER; DEPRESSION; DISEASE MODELS, ANIMAL; HUMANS; IRRITABLE MOOD; MODELS, PSYCHOLOGICAL; MOTOR ACTIVITY; PHENOTYPE; SEXUAL BEHAVIOR, ANIMAL; SLEEP DISORDERS;

EID: 33748198275     PISSN: 02698811     EISSN: 14617285     Source Type: Journal    
DOI: 10.1177/0269881106060241     Document Type: Review

References (80)

1. Adriani W, Caprioli A, Granstrem O, Carli M, Laviola G (2003) The spontaneously hypertensive-rat as an animal model of ADHD: evidence for impulsive and non-impulsive subpopulations. Neurosci Biobehav Rev 27: 639-651
2. Agmo A, Medrano A, Garrido N, Alonso P (1997) GABAergic drugs inhibit amphetamine-induced distractibility in the rat. Pharmacol Biochem Behav 55: 119-126
3. Bachmanov A A, Tordoff M G, Beauchamp G K (1996) Ethanol consumption and taste preferences in C57BL/6ByJ and 129/J mice. Alcohol Clin Exp Res 20: 201-206
4. Bebchuk J M, Arfken C L, Dolan-Manji S, Murphy J, Hasanat K, Manji H K (2000) A preliminary investigation of a protein kinase C inhibitor in the treatment of acute mania. Arch Gen Psychiatr 57: 95-97
5. Belozertseva I V, Sukhotina I A, Vossen J M, Bespalov A Y (2004) Facilitation of aggressive and sexual behaviors by saccharin deprivation in rats. Physiol Behav 80: 531-539
6. Berridge C W, Stalnaker T A (2002) Relationship between low-dose amphetamine-induced arousal and extracellular norepinephrine and dopamine levels within prefrontal cortex. Synapse 46: 140-149
7. Blanchard R J, Wall P M, Blanchard D C (2003) Problems in the study of rodent aggression. Horm Behav 44: 161-170
8. Blasig J, Herz A, Reinhold K, Zieglgansberger S (1973) Development of physical dependence on morphine in respect to time and dosage and quantification of the precipitated withdrawal syndrome in rats. Psychopharmacol 33: 19-38
9. Blednov Y A, Jung S, Alva H, Wallace D, Rosahl T, Whiting P J, Harris R A (2003) Deletion of the alphal or beta2 subunit of GABAA receptors reduces actions of alcohol and other drugs. J Pharmacol Exp Ther 304: 30-36
10. Chateau D, Aron C L (1988) Heterotypic sexual behavior in male rats after lesions in different amygdaloid nuclei. Horm Behav 22: 379-387
11. Chen G, Masana M I, Manji H K (2000) Lithium regulates PKC-mediated intracellular cross-talk and gene expression in the CNS in vivo. Bipolar Dis 2 (3 Pt 2): 217-236
12. Cohen H, Zohar J, Matar M (2003) The relevance of differential response to trauma in an animal model of posttraumatic stress disorder. Biol Psychiatr 53: 463-473
13. Csaba G, Karabelyos C (2001) The effect of a single neonatal treatment (hormonal imprinting) with the antihormones, tamoxifen and mifepristone on the sexual behavior of adult rats. Pharmacol Res 43: 531-534
14. Dalhouse A D (1976) Social cohesiveness, hypersexuality and irritability induced by p-CPA in the rat. Physiol Behav 17: 679-686
15. D'Aquila P S, Brain P, Willner P (1994) Effects of chronic mild stress on performance in behavioural tests relevant to anxiety and depression. Physiol Behav 56: 861-867
16. Dorner G, Docke F, Hinz G (1969) Homo- and hypersexuality in rats with hypothalamic lesions. Neuroendocrinol 4: 20-24
17. Einat H (2004) Animal models for bipolar disorder - new understandings and new possibilities. Neuropsychopharmacol (Suppl. 1): S13
18. Einat H, Belmaker R H (2001) Animal models of psychiatric diseases: possibilities, limitations, examples and demonstration of use. Harefuah 140: 458-463, 568
19. Einat H, Szechtman H (1993) Longlasting consequences of chronic treatment with the dopamine agonist quinpirole for the undrugged behavior of rats. Behav Brain Res 54: 35-41
20. Einat H, Belmaker R H, Manji H (2003a) New approaches to modeling bipolar disorder - from face to construct validity. Psychopharmacol Bull 37: 47-63
21. Einat H, Chen G, Manji H (2004) Possible involvement of protein kinase C (PKC) in bipolar disorder and its treatment. Harefuah 143: 420-425
22. Einat H, Kofman O, Belmaker R H (2000) Animal models of bipolar disorder: from a single episode to progressive cycling models. In Myslobodsky M, Weiner I (eds), Contemporary issues in modeling psychopharmacology. Kluwer Academic Publishers, Boston, pp. 165-180
23. Einat H, Yuan P, Dogra S, Manji H K (2003) Does the PKC signaling pathway play a role in the pathophysiology and treatment of bipolar disorder? Biological Psychiatr 53 (Suppl. 8): S-399
24. Einat H, Belmaker R H, Zangen A, Overstreet D H, Yadid G (2002) Chronic inositol treatment reduces depression-like immobility of Flinders Sensitive Line rats in the forced swim test. Depress Anxiety 15: 148-151
25. Einat H, Karbovski H, Korik J, Tsalah D, Belmaker R H (1999) Inositol reduces depressive-like behaviors in two different animal models of depression. Psychopharmacol (Berl) 144: 158-162
26. Einat H, Yuan P, Gould T D, Li J, Du J, Zhang L, Manji H K, Chen G (2003) The role of the extracellular signal-regulated kinase signaling pathway in mood modulation. J Neurosci 23: 7311-7316
27. Ferrari F, Tartoni P G, Monti A, Mangiafico V (1989) Does anxiety underly imidazole-induced behavioural effects in the rat? Psychopharmacol (Berl) 99: 345-351
28. Ferreira-Nuno A, Overstreet D H, Morales-Otal A, Velazquez-Moctezuma J (2002) Masculine sexual behavior features in the Flinders sensitive and resistant line rats. Behav Brain Res 128: 113-119
29. Frye C A, Rhodes M E, Walf A, Harney J P (2002) Testosterone enhances aggression of wild-type mice but not those deficient in type I 5alpha-reductase. Brain Res 948: 165-170
30. Gessa G L, Pani L, Fadda P, Fratta W (1995) Sleep deprivation in the rat: an animal model of mania. Eur Neuropsychopharmacol 5 (Suppl.): 89-93
31. Gottesman I I, Gould T D (2003) The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatr 160: 636-645
32. Hagan J J, Jansen J H, Broekkamp C L (1988) Selective behavioural impairment after acute intoxication with trimethyltin (TMT) in rats. Neurotoxicol 9: 53-74
33. Hall F S, Huang S, Fong G W, Pert A, Linnoila M (1998) Effects of isolation-rearing on voluntary consumption of ethanol, sucrose and saccharin solutions in Fawn Hooded and Wistar rats. Psychopharmacol (Berl) 139: 210-216
34. Harrold J A, Williams G (2003) The cannabinoid system: a role in both the homeostatic and hedonic control of eating? Br J Nutr 90: 729-734
35. Hayaishi O (1999) Prostaglandin D2 and sleep - a molecular genetic approach. J Sleep Res 8 (Suppl. 1): 60-64
36. Himmelsbach C K, Gerlach G H, Stanton E J (1935) A method for testing addiction, tolerance and abstinence in the rat: results of its application to several morphine alcaloids. Pharmacology and Experimental Therapeutics 53: 179-188
37. Holmes A, Murphy D L, Crawley J N (2002) Reduced aggression in mice lacking the serotonin transporter. Psychopharmacol (Berl) 161: 160-167. Epub 22 March 2002
38. Humphries C R, O'Brien M, Paxinos G (1980) PCA: effects on ejaculation, thermoregulation, salivation, and irritability in rats. Pharmacol Biochem Behav 12: 851-854
39. Humphries C R, Paxinos G, O'Brien M (1981) Mechanisms of PCA-induced hypothermia, ejaculation, salivation and irritability in rats. Pharmacol Biochem Behav 15: 197-200
40. Islam M W, Tariq M, Ageel A M, al-Said M S, al-Yhya A M (1991) Effect of Salvia haematodes on sexual behaviour of male rats. J Ethnopharmacol 33: 67-72
41. Kampov-Polevoy A B, Garbutt J C, Janowsky D S (1999) Association between preference for sweets and excessive alcohol intake: a review of animal and human studies. Alcohol 34: 386-395
42. Kavaliers M, Choleris E, Colwell D D (2001) Brief exposure to female odors 'emboldens' male mice by reducing predator-induced behavioral and hormonal responses. Horm Behav 40: 497-509
43. Kelley S P, Bratt A M, Hodge C W (2003) Targeted gene deletion of the 5-HT3A receptor subunit produces an anxiolytic phenotype in mice. Eur J Pharmacol 461: 19-25
44. Kofman O, Belmaker R H (1991) Animal models of mania and bipolar affective disorders. In Soubrie P (ed.), Anxiety, Depression and Mania. Karger, New York, pp. 103-121
45. Kuruvilla A, Uretsky N J (1981) Effect of sodium valproate on motor function regulated by the activation of GABA receptors. Psychopharmacol (Berl) 72: 167-172
46. Langebartels A, Mathias S, Lancel M (2001) Acute effects of melatonin on spontaneous and picrotoxin-evoked sleep-wake behaviour in the rat. J Sleep Res 10: 211-217
47. Legrand R, Fielder R (1973) Role of dominance-submission relationships in shock-induced fighting of mice. J Comp Physiol Psychol 82: 501-506
48. Lenox R H, Gould T D, Manji H K (2002) Endophenotypes in bipolar disorder. Am J Med Genet 114: 391-406
49. Lerer B, Globus M, Brik E, Hamburger R, Belmaker R H (1984) Effect of treatment and withdrawal from chronic lithium in rats on stimulant-induced responses. Neuropsychobiol 11: 28-32
50. Malatynska E, Knapp R J (2005) Dominant-submissive behavior as models of mania and depression. Neurosci Biobehav Rev 29: 715-737
51. Manji H K, Duman R S (2001) Impairments of neuroplasticity and cellular resilience in severe mood disorders: implications for the development of novel therapeutics. Psychopharmacol Bull 35: 5-49
52. Miczek K A, O'Donnell J M (1978) Intruder-evoked aggression in isolated and nonisolated mice: effects of psychomotor stimulants and L-dopa. Psychopharmacol (Berl) 57: 47-55
53. Miczek K A, Maxson S C, Fish E W, Faccidomo S (2001) Aggressive behavioral phenotypes in mice. Behav Brain Res 125: 167-181
54. Mikics E, Kruk M R, Haller J (2004) Genomic and non-genomic effects of glucocorticoids on aggressive behavior in male rats. Psychoneuroendocrinol 29: 618-635
55. Morozov A, Yin D, Malleret G, Santorelli L, Hen R, LeSauter J, Silver R, Dragatsis I, Kandel E (2001) Generation and characterization of mice with the conditional knockout of BDNF. Society for Neuroscience. Abstract 686-688
56. Nestler E J, Gould E, Manji H, Buncan M, Duman R S, Greshenfeld H K, Hen R, Koester S, Lederhendler I, Meaney M, Robbins T, Winsky L, Zalcman S (2002) Preclinical models: status of basic research in depression. Biol Psychiatr 52: 503-528
57. Nikulina E M, Klimek V (1993) Strain differences in clonidine-induced aggressiveness in mice and its interaction with the dopamine system. Pharmacol Biochem Behav 44: 821-825
58. O'Brien W T, Harper A D, Jove F, Woodgett J R, Maretto S, Piccolo S, Klein P S (2004) Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium. J Neurosci 24: 6791-6798
59. Osterlund M K, Overstreet D H, Hurd Y L (1999) The flinders sensitive line rats, a genetic model of depression, show abnormal serotonin receptor mRNA expression in the brain that is reversed by 17beta-estradiol. Brain Res Mol Brain Res 74: 158-166
60. Persinger M A (1994) Maintained hypersexuality between male rats following chronically induced limbic seizures: implications for bisexuality in complex partial epileptic seizures. Psychol Rep 74: 647-652
61. Popova N K, Vishnivetskaya G B, Ivanova E A, Skrinskaya J A, Seif I (2000) Altered behavior and alcohol tolerance in transgenic mice lacking MAO A: a comparison with effects of MAO A inhibitor clorgyline. Pharmacol Biochem Behav 67: 719-727
62. Post R M, Weiss S R (1989) Sensitization, kindling, and anticonvulsants in mania. J Clin Psychiatry 50 (Suppl.): 23-30
63. Quartermain D, Stone E A, Charbonneau G (1996) Acute stress disrupts risk assessment behavior in mice. Physiol Behav 59: 937-940
64. Ralph-Williams R J, Paulus M P, Zhuang X, Hen R, Geyer M A (2003) Valproate attenuates hyperactive and perseverative behaviors in mutant mice with a dysregulated dopamine system. Biol Psychiatr 53: 352-359
65. Rasmussen K, Beitner-Johnson D B, Krystal J H, Aghajanian G K, Nestler E J (1990) Opiate withdrawal and the rat locus coeruleus: behavioral, electrophysiological, and biochemical correlates. J Neurosci 10: 2308-2317
66. Satoh S, Matsumura H, Nakajima T, Nakahama K, Kanbayashi T, Nishino S, Yoneda H, Shigeyoshi Y (2003) Inhibition of rostral basal forebrain neurons promotes wakefulness and induces FOS in orexin neurons. Eur J Neurosci 17: 1635-1645
67. Shaldivin A, Kaptsan A, Belmaker R H, Einat H, Grisaru N (2001) Transcranial magnetic stimulation in an amphetamine hyperactivity model of mania. Bipolar Disord 3: 30-34
68. Shaldubina A, Einat H, Szechtman H, Shimon H, Belmaker R H (2002) Preliminary evaluation of oral anticonvulsant treatment in the quinpirole model of bipolar disorder. J Neural Transm 109: 433-440
69. Sheard M H (1973) Aggressive behavior: Modification by amphetamine, p-chlorophenylalanine and lithium in rats. Agressologie 14: 327-330
70. Smith D F (1981) Central and peripheral effects of lithium on amphetamine-induced hyperactivity in rats. Pharmacol Biochem Behav 14: 439-442
71. Soderpalm A H, Hansen S (1998) Benzodiazepines enhance the consumption and palatability of alcohol in the rat. Psychopharmacol 137: 215-222
72. Szechtman H, Eckert M J, Tse W S, Boersma J T, Bonura C A, McClelland J Z, Culver K E, Eilam D (2001) Compulsive checking behavior of quinpirole-sensitized rats as an animal model of Obsessive-Compulsive Disorder(OCD): form and control. BMC Neurosci 2: 4
73. Szechtman H, Eilam D (2005) Psychiatric models. In Whishaw I Q, Kolb B (eds), The Behavior of the Laboratory Rat: A Handbook with Tests. Oxford University Press, London, pp. 462-474
74. Tecott L H, Nestler E J (2004) Neurobehavioral assessment in the information age. Nat Neurosci 7: 462-466
75. Ulrich R E, Craine W H (1964) Behavior: persistence of shock-induced aggression. Science 143: 971-973
76. Wei E (1973) Assessment of precipitated abstinence in morphine-dependent rats. Psychopharmacol 28: 35-44
77. Willner P (1984) The validity of animal models of depression. Psychopharmacology (Berl) 83: 1-16
78. Willner P (1986) Validation criteria for animal models of human mental disorders: learned helplessness as a paradigm case. Prog Neuropsychopharmacol Biol Psychiatr 10: 677-690
79. Willner P (1991) Behavioral models in psychopharmacology. In Willner P (ed.), Behavioral models in psychopharmacology: theoretical, industrial and clinical perspectives. Cambridge University Press, Cambridge, pp. 3-19
80. Willner P, Towell A, Sampson D, Sophokleous S, Muscat R (1987) Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant. Psychopharmacol (Berl) 93: 358-364