The Flinders Sensitive Line rats, a genetic model of depression, show abnormal serotonin receptor mRNA expression in the brain that is reversed by 17β-estradiol

Molecular Brain Research

Volumn 74, Issue 1-2, 1999, Pages 158-166

  Österlund, Marie K ^a   Overstreet, David H ^b   Hurd, Yasmin L ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Affective disorder; Estrogen; In situ hybridization; Limbic system; mRNA

Indexed keywords

ESTRADIOL; ESTROGEN RECEPTOR; MESSENGER RNA; RECEPTOR SUBTYPE; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN RECEPTOR;

AMYGDALOID NUCLEUS; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BRAIN; BRAIN CORTEX; BRAIN REGION; DEPRESSION; GENE EXPRESSION; HIPPOCAMPUS; IN SITU HYBRIDIZATION; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; PYRIFORM CORTEX; RAT;

ANIMALS; BRAIN; DEPRESSION; DISEASE MODELS, ANIMAL; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; GENE EXPRESSION REGULATION; IN SITU HYBRIDIZATION; MALE; RATS; RATS, INBRED STRAINS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, ESTROGEN; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; RNA PROBES; RNA, MESSENGER;

ANIMALIA;

EID: 0033387235     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(99)00274-0     Document Type: Article

References (69)

1. Arango V., Underwood M.D., Gubbi A.V., Mann J.J. Localized alterations in pre- and postsynaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims. Brain Res. 688:1995;121-133.
2. 2 binding sites in the frontal cortex of suicide victims and control subjects. Am. J. Psychiatry. 146:1989;730-736.
3. Åsberg M., Bertilsson L., Mårtensson B., Scalia G.P., Thoren P., Träskman-Bendz L. CSF monoamine metabolites in melancholia. Acta Psychiatr. Scand. 69:1984;201-219.
4. Åsberg M., Träskman L., Thorén P. 5-HIAA in the cerebrospinal fluid: a biochemical suicide predictor. Arch. Gen. Psychiatry. 33:1976;1193-1197.
5. 2 receptor imaging in major depression: focal changes in orbito-insular cortex. Br. J. Psychiatry. 171:1997;444-448.
6. 2A receptors and the abundances of 5-HT receptor and transporter mRNA in the cortex, hippocampus and dorsal raphe of three strains of rat. Brain Res. 28:1994;311-324.
7. 2A receptor expression. NeuroReport. 6:1995;901-904.
8. Caberlotto L., Fuxe K., Overstreet D.H., Gerrard P., Hurd Y.L. Alterations in neuropeptide Y and Y1 receptor mRNA expression in brains from an animal model of depression: region specific adaptation after fluoxetine treatment. Mol. Brain Res. 59:1998;58-65.
9. 1A binding in rat brain - a combined in situ hybridisation/in vitro autoradiographic study. Brain Res. 561:1991;51-60.
10. Cheetham S.C., Crompton M.R., Czudek C., Horton R.W., Katona C.L., Reynolds G.P. Serotonin concentrations and turnover in brains of depressed suicides. Brain Res. 502:1989;332-340.
11. 2 receptor binding sites in depressed suicide victims. Brain Res. 443:1988;272-280.
12. 1 binding sites in depressed suicides. Psychopharmacology. 102:1990;544-548.
13. Cochran E., Robins E., Grote S. Regional serotonin levels in brain: a comparison of depressive suicides and alcoholic suicides with controls. Biol. Psychiatry. 11:1976;283-294.
14. 2A receptors: emphasis on the rat frontal cortex. Neuroscience. 83:1998;829-836.
15. 1A receptor agonists: recent developments and controversial issues. Psychopharmacology. 121:1995;1-26.
16. Dohanich G.P., Daniel J.M., Fader A.J., Wolff S.C., Gallogy P.M., Overstreet D.M. Sexual behavior of Flinders line female rats bred for differential cholinergic sensitivities. Horm. Behav. 33:1998;77-84.
17. 2 and beta-adrenergic receptor regulation in rat brain following chronic treatment with desipramine and fluoxetine alone and in combination. J. Neurochem. 62:1994;2262-2268.
18. Gregoire A.J.P., Kumar R., Everitt B., Henderson A.F., Studd J.W.W. Transdermal oestrogen for treatment of severe postnatal depression. Lancet. 347:1996;930-933.
19. 3H ]ketanserin binding in the human brain postmortem: effect of suicide Brain Res. 507:1990;208-215.
20. 2 receptors in rat brain: an autoradiographic study. Synapse. 14:1993;324-331.
21. 2 sites in cortex and amygdala. Brain Res. 18:1993;37-44.
22. Janowski D.S., El-Yousefi M.K., Davis J.M., Sekerke H.J. A cholinergic-adrenergic hypothesis of mania and depression. Lancet. 2:1972;632-635.
23. Janowski D.S., Risch S.C., Parker D., Huey L.Y., Judd L.L. Increased vulnerability to cholinergic stimulation in affective disorder patients. Psychopharmacol. Bull. 16:1980;29-31.
24. Joyce J.N., Shane A., Lexow N., Winokur A., Casanova M.F., Kleinman J.E. Serotonin uptake sites and serotonin receptors are altered in the limbic systems of schizophrenics. Neuropsychopharmacology. 8:1993;315-336.
25. Kellar K.J., Cascio C.S., Butler J.A., Kurtzke R.N. Differential effects of electroconvulsive shock and antidepressant drugs on serotonin-2 receptors in rat brain. Eur. J. Pharmacol. 19:1981;515-518.
26. 2 receptors after chronic administration of levoprotiline, (+)-oxaprotiline and other antidepressant drugs. Pol. J. Pharmacol. Pharm. 44:1992;549-560.
27. Lauber A.H., Mobbs C.V., Muramatsu M., Pfaff D.W. Estrogen receptor messenger RNA expression in rat hypothalamus as a function of genetic sex and estrogen dose. Endocrinology. 129:1991;3180-3186.
28. Lauber A.H., Romano G.J., Mobbs C.V., Pfaff D.W. Estradiol regulation of estrogen receptor messenger ribonucleic acid in rat mediobasal hypothalamus: an in situ hybridisation study. J. Neuroendocrinol. 2:1990;605-611.
29. J.E. LeDoux, Emotion and the amygdala, in: J.P. Aggleton (Ed.), Neurobiology Aspects of Emotion, Memory, and Mental Dysfunction, Wiley-Liss, New York, 1992, pp. 339-352.
30. Lehtinen V., Joukamaa M. Epidemiology of depression: prevalence, risk factors and treatment situation. Acta Psychiatr. Scand., Suppl. 377:1994;7-10.
31. Lesch K.-P., Aulakh C.S., Wolozin B.L., Murphy D.L. Serotonin (5-HT) receptor, 5-HT transporter and G protein-effector expression: implications for depression. Pharmacol. Toxicol. 71:1992;49-60. Suppl. 1.
32. 2 receptors in suicide victims: violence of death, depression and effects of antidepressant treatment. Brain Res. 11:1994;281-289.
33. 2A receptors studied in depressive patients during chronic treatment by selective serotonin reuptake inhibitors. Psychopharmacology (Berl.). 133:1997;99-101.
34. 1A binding sites in frontal cortex of suicide victims. J. Neural Transm. 85:1991;181-194.
35. Mayberg H.S. Limbic-cortical dysregulation: a proposed model of depression. J. Neuropsychiatry. 9:1997.
36. McQueen J.K., Wilson H., Fink G. Estradiol-17β increases serotonin transporter (SERT) mRNA levels and the density of SERT-binding sites in the female rat brain. Mol. Brain. Res. 45:1997;13-23.
37. H.Y. Meltzer, M.T. Lowy, The serotonin hypothesis of depression, in: H.Y. Meltzer (Ed.), Psychopharmacology: The Third Generation of Progress, Raven Press, New York, 1987, pp. 513-526.
38. Micevych P.E., Abelson L., Fok H., Ulibarri C., Priest C.A. Gonadal steroid control of preprocholecystokinin mRNA expression in the limbic-hypothalamic circuit: comparison of adult with neonatal steroid treatments. J. Neurosci. Res. 38:1994;386-398.
39. Mizuta T., Segawa T. Chronic effects of imipramine and lithium on 5-HT receptor subtypes in rat frontal cortex, hippocampus and choroid plexus: guantitative receptor autoradiographic analyses. Jpn. J. Pharmacol. 50:1989;315-326.
40. Ohmori T., Arora R.C., Meltzer H.Y. Serotonergic measures in suicide brain: the concentration of 5-HIAA, HVA and tryptophan in frontal cortex of suicide victimes. Biol. Psychiatry. 32:1992;57-71.
41. Österlund M., Kuiper G.G.J.M., Gustafsson J.-Å., Hurd Y.L. Differential distribution and regulation of estrogen receptor-α and -β mRNA within the female rat brain. Mol. Brain Res. 54:1998;175-180.
42. 1A receptor mRNA and binding levels in the rat brain, Synapse, 1999, In press.
43. 1A receptor mRNA expression in the limbic system of female rats. Mol. Brain Res. 55:1998;169-172.
44. Overstreet D.H. The Flinders Sensitive Line rats: a genetic animal model of depression. Neurosci. Biobehav. Rev. 17:1993;51-68.
45. Overstreet D.H., Pucilowski O., Rezvani A.H., Janowski D.S. Administration of antidepressants, diazepam and psychomotor stimulants further confirms the utility of Flinders Sensitive Line rats as an animal model of depression. Psychopharmacology. 121:1995;27-37.
46. Overstreet D.H., Rezvani A.H., Janowski D.S. Genetic animal models of depression and ethanol preference provide support for cholinergic and serotonergic involvement in depression and alcoholism. Biol. Psychiatry. 31:1992;919-936.
47. Overstreet D.H., Overstreet W., Overstreet R.R., Helps S.C., Messenger M. Selective breeding for sensitivity to the anticholinesterase, DFP. Psychopharmacology. 65:1979;15-20.
48. Papez J.W. A proposed mechanism of emotion. Arch. Neurol. Psychiatry. 38:1937;725-743.
49. G. Paxinos, C. Watson, The Rat Brain in Stereotaxic Coordinates, Academic Press, San Diego, USA, 1997.
50. Paykel E.S. Depression in women. Br. J. Psychiatry. 158:1991;22-29. Suppl. 10.
51. Pearlstein T., Rosen K., Stone A.B. Mood disorders and menopause. Endocrinol. Metab. Clin. North Am. 26:1997;279-294.
52. Pecins-Thompson M., Brown N., Bethea C.L. Regulation of serotonin re-uptake transporter mRNA expression by ovarian steroids in rhesus macaques. Mol. Brain Res. 53:1998;120-129.
53. 2C receptors. Mol. Brain Res. 23:1994;163-178.
54. Quintana J. Platelet serotonin and plasma tryptophan decreases in endogenous depression Clinical, therapeutic and biological correlation. J. Affect. Disord. 1992:1992;55-62.
55. Risch S.C., Kalin N.H., Janowski D.S. Cholinergic challenge in affective illness: behavioral and neuroendocrine correlates. J. Clin. Psychopharmacol. 1:1981;186-192.
56. 2A-activated interneuron. Brain Res. 506:1990;62-69.
57. Shughrue P.J., Lane M.V., Merchenthaler I. Comparative distribution of estrogen receptor-α and -β mRNA in the rat central nervous system. J. Comp. Neurol. 388:1997;507-525.
58. Sichel D.A., Cohen L.S., Robertson L.M., Ruttenberg A., Rosenbaum J.F. Prophylactic estrogen in recurrent postpartum affective disorder. Biol. Psychiatry. 38:1995;814-818.
59. Simerly R.B., Young B.J. Regulation of estrogen receptor messenger ribonucleic acid in rat hypothalamus by sex steroid hormones. Mol. Endocrinol. 5:1991;424-432.
60. Simerly R.B., Young M.A., Capozza M.A., Swanson L.W. Estrogen differentially regulates neuropeptide gene expression in a sexually dimorphic olfactory pathway. Proc. Natl. Acad. Sci. U.S.A. 86:1989;4766-4770.
61. 2 binding site in frontal cortex of suicide victims. Lancet. 1:1983;214-216.
62. Stockmeier C.A., Dilley G.E., Shapiro B.S., Overholst J.C., Thompson P.A., Meltzer H.Y. Serotonin receptors in suicide victims with major depression. Neuropsychopharmacology. 16:1997;162-173.
63. Stockmeier C.A., Shapiro L.A., Dilley G.E., Kolli T.N., Friedman L., Rajkowska G. Increase in serotonin-1A autoreceptors in the midbrain of suicide victims with major depression-postmortem evidence for decreased serotonin activity. J. Neurosci. 18:1998;7394-7401.
64. 2A receptors in cerebral cortex and nucleus accumbens in the female rat. J. Steroid Biochem. Mol. Biol. 54:1995;15-20.
65. Uphouse L. Multiple serotonin receptors: too many, not enough, or just the right number? Neurosci. Behav. Rev. 21:1997;679-698.
66. van Praag H.M. Depression, suicide and the metabolites of serotonin in the brain. J. Affect. Disord. 4:1983;275-290.
67. 2 receptors and transport sites for serotonin. Brain Res. 25:1993;87-94.
68. Zangen A., Overstreet D.H., Yadid G. Increased catecholamine levels in specific brain regions of a rat model of depression: normalized by chronic antidepressant treatment. Brain Res. 10:1999;243-250.
69. Zangen A., Overstreet D.H., Yalid G. High serotonin and 5-hydroxyindoleacetic acid levels in limbic brain regions in a rat model of depression: normalization by chronic antidepressant treatment. J. Neurochem. 69:1997;2477-2483.