Reversal of HCN channel voltage dependence via bridging of the S4-S5 linker and post-S6

Journal of General Physiology

Volumn 128, Issue 3, 2006, Pages 273-282

  Prole, David L ^a   Yellen, Gary ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; ION CHANNEL;

ARTICLE; CHANNEL GATING; CROSS LINKING; ENZYME REGULATION; FIBROBLAST; HUMAN; HUMAN CELL; HYPERPOLARIZATION; NUCLEOTIDE SEQUENCE; PACEMAKER NERVE CELL; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; CELLS, CULTURED; CYCLIC AMP; CYCLIC NUCLEOTIDE-GATED CATION CHANNELS; CYSTEINE; HUMANS; ION CHANNEL GATING; ION CHANNELS; MEMBRANE POTENTIALS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; POINT MUTATION; POTASSIUM CHANNELS; PROTEIN STRUCTURE, SECONDARY; PROTEIN SUBUNITS; SEA URCHINS;

EID: 33748125213     PISSN: 00221295     EISSN: 00221295     Source Type: Journal    
DOI: 10.1085/jgp.200609590     Document Type: Article

References (31)

1. Bell, D.C., H. Yao, R.C. Saenger, J.H. Riley, and S.A. Siegelbaum. 2004. Changes in local S4 environment provide a voltage-sensing mechanism for mammalian hyperpolarization-activated HCN channels. J. Gen. Physiol. 123:5-19.
2. Cordero-Morales, J.F., L.G. Cuello, and E. Perozo. 2006. Voltage-dependent gating at the KcsA selectivity filter. Nat. Struct. Mol. Biol. 13:319-322.
3. Craven, K.B., and W.N. Zagotta. 2004. Salt bridges and gating in the COOH-terminal region of HCN2 and CNGA1 channels. J. Gen. Physiol. 124:663-677.
4. Decher, N., J. Chen, and M.C. Sanguinetti. 2004. Voltage-dependent gating of hyperpolarization-activated, cyclic nucleotide-gated pacemaker channels: molecular coupling between the S4-S5 and C-linkers. J. Biol. Chem. 279:13859-13865.
5. + channel. Neuron. 32:649-656.
6. + channel. J. Biol. Chem. 281:12858-12864.
7. Flynn, G.E., and W.N. Zagotta. 2001. Conformational changes in S6 coupled to the opening of cyclic nucleotide-gated channels. Neuron. 30:689-698.
8. Gauss, R., R. Seifert, and U.B. Kaupp. 1998. Molecular identification of a hyperpolarization-activated channel in sea urchin sperm. Nature. 393:583-587.
9. + channel S4. Neuron. 16:387-397.
10. Lehrer, S.S. 1975. Intramolecular crosslinking of tropomyosin via disulfide bond formation: evidence for chain register. Proc. Natl. Acad. Sci. USA. 72:3377-3381.
11. + channel. Neuron. 19:175-184.
12. Long, S.B., E.B. Campbell, and R. Mackinnon. 2005. Voltage sensor of Kv1.2: structural basis of electromechanical coupling. Science. 309:903-908.
13. + channels. J. Gen. Physiol. 120:663-676.
14. Mannikko, R., F. Elinder, and H.P. Larsson. 2002. Voltage-sensing mechanism is conserved among ion channels gated by opposite voltages. Nature. 419:837-841.
15. Martell, A.E., and R.M. Smith. 1998. Critically selected stability constants of metal complexes. NIST Standard Reference Database 46, version 5.0.
16. Means, G.E., and R.E. Feeney. 1971. Chemical Modification of Proteins. Holden-Day Inc., San Francisco, CA. 156.
17. + channel by three amino acid substitutions. Neuron. 16:853-858.
18. Pathak, M., L. Kurtz, F. Tombola, and E. Isacoff. 2005. The cooperative voltage sensor motion that gates a potassium channel. J. Gen. Physiol. 125:57-69.
19. Proenza, C., and G. Yellen. 2006. Distinct populations of HCN pacemaker channels produce voltage-dependent and voltage-independent currents. J. Gen. Physiol. 127:183-190.
20. Roncaglia, P., P. Mistrik, and V. Torre. 2002. Pore topology of the hyperpolarization-activated cyclic nucleotide-gated channel from sea urchin sperm. Biophys. J. 83:1953-1964.
21. Rothberg, B.S., K.S. Shin, P.S. Phale, and G. Yellen. 2002. Voltage-controlled gating at the intracellular entrance to a hyperpolarization-activated cation channel. J. Gen. Physiol. 119:83-91.
22. Rothberg, B.S., K.S. Shin, and G. Yellen. 2003. Movements near the gate of a hyperpolarization-activated cation channel. J. Gen. Physiol. 122:501-510.
23. + channel. Cell. 123:463-475.
24. Shin, K.S., B.S. Rothberg, and G. Yellen. 2001. Blocker state dependence and trapping in hyperpolarization-activated cation channels: evidence for an intracellular activation gate. J. Gen. Physiol. 117:91-101.
25. Shin, K.S., C. Maertens, C. Proenza, B.S. Rothberg, and G. Yellen. 2004. Inactivation in HCN channels results from reclosure of the activation gate: desensitization to voltage. Neuron. 41:737-744.
26. Smith, P.L., T. Baukrowitz, and G. Yellen. 1996. The inward rectification mechanism of the HERG cardiac potassium channel. Nature. 379:833-836.
27. Tombola, F., M.M. Pathak, and E.Y. Isacoff. 2005. How far will you go to sense voltage? Neuron. 48:719-725.
28. 2+ channels. J. Biol. Chem. 277:18994-19000.
29. Wang, J., S. Chen, and S.A. Siegelbaum. 2001. Regulation of hyperpolarization-activated HCN channel gating and cAMP modulation due to interactions of COOH terminus and core transmembrane regions. J. Gen. Physiol. 118:237-250.
30. Zagotta, W.N., N.B. Olivier, K.D. Black, E.C. Young, R. Olson, and E. Gouaux. 2003. Structural basis for modulation and agonist specificity of HCN pacemaker channels. Nature. 425:200-205.
31. Zilberberg, N., N. Ilan, and S.A. Goldstein. 2001. KCNKO: opening and closing the 2-P-domain potassium leak channel entails "C-type" gating of the outer pore. Neuron. 32:635-648.