Inactivation in HCN channels results from reclosure of the activation gate: Desensitization to voltage

Neuron

Volumn 41, Issue 5, 2004, Pages 737-744

  Shin, Ki Soon ^a,b   Maertens, Chantal ^a,c   Proenza, Catherine ^a   Rothberg, Brad S ^a,d   Yellen, Gary ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b Kyung Hee University Hospital   (South Korea)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATION CHANNEL; CYCLIC AMP;

ARTICLE; CHANNEL GATING; ELECTRIC CONDUCTIVITY; ELECTRIC POTENTIAL; HYPERPOLARIZATION ACTIVATED CATION CHANNEL; INHIBITION KINETICS; PHENOTYPE; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION;

BINDING SITES; CELL LINE; CYCLIC AMP; HUMANS; ION CHANNEL GATING; ION CHANNELS; MEMBRANE POTENTIALS; MUSCLE PROTEINS;

EID: 1542328883     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(04)00083-2     Document Type: Article

References (21)

1. Brown H.F., DiFrancesco D., Noble S.J. How does adrenaline accelerate the heart? Nature. 280:1979;235-236.
2. Cole K.S., Moore J.W. Potassium ion current in the squid giant axon. dynamic characteristic Biophys. J. 1:1960;1-14.
3. DiFrancesco D. Pacemaker mechanisms in cardiac tissue. Annu. Rev. Physiol. 55:1993;455-472.
4. DiFrancesco D., Tortora P. Direct activation of cardiac pacemaker channels by intracellular cyclic AMP. Nature. 351:1991;145-147.
5. Gauss R., Seifert R., Kaupp U.B. Molecular identification of a hyperpolarization-activated channel in sea urchin sperm. Nature. 393:1998;583-587.
6. Hamill O.P., Marty A., Neher E., Sakmann B., Sigworth F.J. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch. 391:1981;85-100.
7. Hodgkin A.L., Huxley A.F. The dual effect of membrane potential on sodium conductance in the giant axon of Loligo. J. Physiol. 116:1952;497-506.
8. 2+ binding and channel opening in large conductance (BK) potassium channels. J. Gen. Physiol. 120:2002;267-305.
9. Hoshi T., Zagotta W.N., Aldrich R.W. Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science. 250:1990;533-538.
10. Jurman M.E., Boland L.M., Liu Y., Yellen G. Visual identification of individual transfected cells for electrophysiology using antibody-coated beads. Biotechniques. 17:1994;876-881.
11. Ludwig A., Zong X., Jeglitsch M., Hofmann F., Biel M. A family of hyperpolarization-activated mammalian cation channels. Nature. 393:1998;587-591.
12. Malcolm A.T., Kourennyi D.E., Barnes S. Protons and calcium alter gating of the hyperpolarization-activated cation current (I(h)) in rod photoreceptors. Biochim. Biophys. Acta. 1609:2003;183-192.
13. Pape H.C. Queer current and pacemaker. the hyperpolarization-activated cation current in neurons Annu. Rev. Physiol. 58:1996;299-327.
14. Pape H.C., McCormick D.A. Noradrenaline and serotonin selectively modulate thalamic burst firing by enhancing a hyperpolarization-activated cation current. Nature. 340:1989;715-718.
15. Rothberg B.S., Shin K.S., Phale P.S., Yellen G. Voltage-controlled gating at the intracellular entrance to a hyperpolarization-activated cation channel. J. Gen. Physiol. 119:2002;83-91.
16. Rothberg B.S., Shin K.S., Yellen G. Movements near the gate of a hyperpolarization-activated cation channel. J. Gen. Physiol. 122:2003;501-510.
17. Santoro B., Liu D.T., Yao H., Bartsch D., Kandel E.R., Siegelbaum S.A., Tibbs G.R. Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain. Cell. 93:1998;717-729.
18. Seed B., Aruffo A. Molecular cloning of the CD2 antigen, the T-cell erythrocyte receptor, by a rapid immunoselection procedure. Proc. Natl. Acad. Sci. USA. 84:1987;3365-3369.
19. Shin K.S., Rothberg B.S., Yellen G. Blocker state dependence and trapping in hyperpolarization-activated cation channels. evidence for an intracellular activation gate J. Gen. Physiol. 117:2001;91-101.
20. Sun Y., Olson R., Horning M., Armstrong N., Mayer M., Gouaux E. Mechanism of glutamate receptor desensitization. Nature. 417:2002;245-253.
21. Yellen G. The moving parts of voltage-gated ion channels. Q. Rev. Biophys. 31:1998;239-295.