Inhibition of SHH signaling pathway: Molecular treatment strategy of odontogenic keratocyst

Medical Hypotheses

Volumn 67, Issue 5, 2006, Pages 1242-1244

  Zhang, Lu ^a   Sun, Zhi Jun ^b   Zhao, Yi Fang ^b   Bian, Zhuan ^a   Fan, Ming Wen ^a   Chen, Zhi ^a  

^a Wuhan University   (China)

^b WUHAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPAMINE; N (3 METHOXYBENZYL) 3,3 DIMETHYL N [1 (3,4 METHYLENEDIOXYBENZYL) 2 (1 PIPERAZINYLCARBONYL) 4 PYRROLIDINYL]BUTYRAMIDE; RECEPTOR BLOCKING AGENT; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; FRAMESHIFT MUTATION; GENE EXPRESSION; HUMAN; NONHUMAN; ODONTOGENIC CYST; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE;

CARCINOMA, BASAL CELL; CELL DIVISION; HEDGEHOG PROTEINS; HUMANS; JAW; MUTATION; ODONTOGENIC CYSTS; RECURRENCE; SIGNAL TRANSDUCTION;

ERINACEIDAE;

EID: 33748089697     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2006.04.062     Document Type: Article

References (24)

1. Kramer I.R.H., Pindborg J.J., and Shear M. Histological typing of odontogenic tumors. World Health Organization Histological Classification of Tumors. 2nd ed. (1991), Springer-Verlag, Berlin p. 35-36
2. Shear M. The aggressive nature of the odontogenic keratocyst: is it a benign cystic neoplasm? Part 1. Clinical and early experimental evidence of aggressive behavior. Oral Oncol 38 (2002) 219-226
3. High A., and Zedan W. Basal cell nevus syndrome. Curr Opin Oncol 17 (2005) 160-166
4. Ghali G.E., and Scott Connor M. Surgical management of the odontogenic keratocyst. Oral Maxillofacial Surg Clin N Am 15 (2003) 383-392
5. Zhao Y.F., Wei J.X., and Wang S.P. Treatment of odontogenic keratocysts: a follow-up of 255 Chinese patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 94 (2002) 151-156
6. Blanas N., Freund B., Schwartz M., et al. Systematic review of the treatment and prognosis of the odontogenic keratocyst. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 90 (2000) 553-558
7. Cobourne M.T., Miletich I., and Sharpe P.T. Restriction of sonic hedgehog signalling during early tooth development. Development 131 (2004) 2875-2885
8. McMahon A.P. More Surprises in the Hedgehog signaling pathway. Cell 100 (2000) 185-188
9. Zhang Y.D., Chen Z., Song Y.Q., et al. Making a tooth: growth factors, transcription factors, and stem cells. Cell Res 15 (2005) 301-316
10. Wu C., Shimo T., Liu M., et al. Sonic hedgehog functions as a mitogen during bell stage of odontogenesis. Connect Tissue Res 44 Suppl. (2003) 92-96
11. Levanat S., Musani V., Komar A., et al. Role of the hedgehog/patched signaling pathway in oncogenesis: a new polymorphism in the PTCH gene in ovarian fibroma. Ann NY Acad Sci 1030 (2004) 134-143
12. Nishimaki H., Kasai K., Kozaki K., et al. Role of activated Sonic hedgehog signaling for the cellular proliferation of oral squamous cell carcinoma cell line. Biochem Biophys Res Commun 314 (2004) 313-320
13. Sanchez P., Hernandez A.M., Stecca B., et al. Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling. Proc Natl Acad Sci USA 101 (2004) 12561-12566
14. Thayer S.P., di Magliano M.P., Heiser P.W., et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 425 (2003) 851-856
15. Zhang L., Chen X.M., Sun Z.J., et al. Epithelial expression of SHH signaling pathway in odontogenic tumors. Oral Oncol 42 (2006) 398-408
16. Hahn H., Wicking C., Zaphiropoulous P.G., et al. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell 85 (1996) 841-851
17. Johnson R.L., Rothman A.L., Xie J., et al. Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science 272 (1996) 1668-1671
18. Barreto D.C., Gomez R.S., Bale A.E., et al. PTCH gene mutations in odontogenic keratocysts. J Dent Res 79 (2000) 1418-1422
19. Song Y.L., Zhang W.F., Peng B., et al. Germline mutations of the PTCH gene in families with odontogenic keratocysts and nevoid basal cell carcinoma syndrome. Tumor Biol 27 (2006) 175-180
20. Koike C., Mizutani T., Ito T., et al. Introduction of wild-type patched gene suppresses the oncogenic potential of human squamous cell carcinoma cell lines including A431. Oncogene 21 (2002) 2670-2678
21. Taipale J., Chen J.K., Cooper M.D., et al. Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature 406 (2000) 1005-1009
22. Williams J.A., Guicherit O.M., Zaharian B.I., et al. Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions. Proc Natl Acad Sci USA 100 (2003) 4616-4621
23. Romer J.T., Kimura H., Magdaleno S., et al. Suppression of the SHH pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1 (+/-) p53(-/-) mice. Cancer Cell 6 (2004) 229-240
24. Wu X.Z. A new classification system of anticancer drugs - based on cell biological mechanisms. Med Hypotheses 66 (2006) 883-887