PPARα-mediated upregulation of uncoupling protein-2 switches cyanide-induced apoptosis to necrosis in primary cortical cells

Toxicological Sciences

Volumn 93, Issue 1, 2006, Pages 136-145

  Li, Li ^a   Prabhakaran, Krishnan ^a   Zhang, Xun ^a   Borowitz, Joseph L ^a   Isom, Gary E ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

Apoptosis; Cell death; Cyanide; Mitochondrial function; Necrosis; PPAR ; UCP 2

Indexed keywords

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; ADENOSINE TRIPHOSPHATE; CYANIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PIRINIXIC ACID; PROPIDIUM IODIDE; UNCOUPLING PROTEIN 2; ION CHANNEL; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN 2; PRIMER DNA; PYRIMIDINE DERIVATIVE; SMALL INTERFERING RNA;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN NERVE CELL; CONTROLLED STUDY; CYTOTOXICITY; EMBRYO; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL TOXICITY; NERVE CELL MEMBRANE POTENTIAL; NERVE CELL NECROSIS; NEUROTOXICITY; NICK END LABELING; NONHUMAN; POLYMERASE CHAIN REACTION; QUANTITATIVE ANALYSIS; RAT; RNA INTERFERENCE; UPREGULATION; WESTERN BLOTTING; ANIMAL; DRUG EFFECT; NECROSIS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT;

ANIMALS; APOPTOSIS; BASE SEQUENCE; CYANIDES; DNA PRIMERS; ION CHANNELS; MITOCHONDRIAL PROTEINS; NECROSIS; PPAR ALPHA; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; UP-REGULATION;

EID: 33747887850     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfl039     Document Type: Article

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