The role of uncoupling proteins in pathophysiological states

Biochemical and Biophysical Research Communications

Volumn 293, Issue 4, 2002, Pages 1145-1152

  Argilés, Josep M ^a   Busquets, Sílvia ^a   López Soriano, Francisco J ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CARRIER PROTEIN; FATTY ACID; REACTIVE OXYGEN METABOLITE; ROSIGLITAZONE; TROGLITAZONE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3; UNCOUPLING PROTEIN 4; WY 1443;

BIOENERGY; BROWN ADIPOSE TISSUE; CACHEXIA; ENERGY BALANCE; ENERGY METABOLISM; FATTY ACID SYNTHESIS; GENE EXPRESSION; GENE FUNCTION; HUMAN; MEMBRANE TRANSPORT; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; MOLECULAR DYNAMICS; NONHUMAN; NONSHIVERING THERMOGENESIS; OBESITY; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PLANT; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTON TRANSPORT; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; THERMOGENESIS; TISSUE DISTRIBUTION;

MAMMALIA;

EID: 0036078870     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)00355-8     Document Type: Article

References (59)

1. Keilin's respiratory chain concept and its chemiosmotic consequences
2. Mitochondrial proton leak: A role for uncoupling proteins 2 and 3?
3. The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP, and AtUCP
4. Thermogenic mechanisms in brown fat
5. Uncoupling protein-2: A novel gene linked to obesity and hyperinsulinemia
6. Cloning and characterization of an uncoupling protein homolog: A potential molecular mediator of human thermogenesis
7. Uncoupling protein-3: A new member of the mitochondrial carrier family with tissue-specific expression
8. UCP3: An uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue
9. Genetic and physiological analysis of the role of uncoupling proteins in human energy homeostasis
10. BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast
11. Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation
12. UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells
13. Development of infrared imaging to measure thermogenesis in cell culture: Thermogenic effects of uncoupling protein-2, troglitazone, and beta-adrenoceptor agonists
14. Assessment of uncoupling activity of the human uncoupling protein 3 short form and three mutants of the uncoupling protein gene using a yeast heterologous expression system
15. Uncoupling protein-3: A muscle-specific gene upregulated by leptin in ob/ob mice
16. Expression of uncoupling protein-3 and mitochondrial activity in the transition from hypothyroid to hyperthyroid state in rat skeletal muscle
17. Increased uncoupling protein-2 and -3 mRNA expression during fasting in obese and lean humans
18. Uncoupling protein-3 expression in rodent skeletal muscle is modulated by food intake but not by changes in environmental temperature
19. Role of UCP homologues in skeletal muscles and brown adipose tissue: Mediators of thermogenesis or regulators of lipids as fuel substrate?
20. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese
21. Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3
22. Energy metabolism in uncoupling protein 3 gene knockout mice
23. Uncoupling protein-2 gene: Reduced mRNA expression in intraperitoneal adipose tissue of obese humans
24. Reduced gene expression of UCP2 but not UCP3 in skeletal muscle of human obese subjects
25. Rat uncoupling protein 2 (UCP2): Expression in obese ventromedial hypothalamus (VMH)-lesioned animals
26. Effects of obesity and stable weight reduction on UCP2 and UCP3 gene expression in humans
27. Increased adipose expression of the uncoupling protein-3 gene by thiazolidinediones in Wistar fatty rats and in cultured adipocytes
28. Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean
29. Skeletal muscle UCP2 and UCP3 gene expression in a rat cancer cachexia model
30. Stimulation of brown adipose tissue activity in tumor-bearing rats
31. Increased gene expression of brown fat uncoupling protein (UCP)1 and skeletal muscle UCP2 and UCP3 in MAC16-induced cancer cachexia
32. Mechanisms of cachexia induced by T-cell leukemia in the rat
33. Increased uncoupling protein-2 gene expression in brain of lipopolysaccharide-injected mice: Role of tumour necrosis factor-α?
34. In the rat, tumor necrosis factor alpha administration results in an increase in both UCP2 and UCP3 mRNAs in skeletal muscle: A possible mechanism for cytokine-induced thermogenesis?
35. Hyperlipemia: A role in regulating UCP3 gene expression in skeletal muscle during cancer cachexia?
36. Tumor necrosis factor-alpha regulates in vivo expression of the rat UCP family differentially
37. Induction of UCP2 gene expression by LPS: A potential mechanism for increased thermogenesis during infection
38. Alternative pathway of respiration in Physarum polycephalum plasmodia
39. Molecular biology of adenosine triphosphate-sensitive potassium channels
40. Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets
41. Tissue-specific expression of the uncoupling protein family in streptozotocin-induced diabetic rats
42. Expression of mRNAs encoding uncoupling proteins in human skeletal muscle: Effects of obesity and diabetes
43. Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue
44. Overexpression of GLUT4 in mice causes up-regulation of UCP3 mRNA in skeletal muscle
45. The role of uncoupling proteins in metabolic fuel partioning and human obesity
46. Uncoupling protein-3 expression in skeletal muscle and free fatty acids in obesity
47. Uncoupling protein-3 gene expression in skeletal muscle during development is regulated by nutritional factors that alter circulating non-esterified fatty acids
48. Up-regulation of uncoupling protein-3 by fatty acid in C2C12 myotubes
49. Up-regulation of uncoupling protein 3 by thyroid hormone, peroxisome proliferator-activated receptor ligands and 9-cis retinoic acid in L6 myotubes
50. Obesity induces expression of uncoupling protein-2 in hepatocytes and promotes liver ATP depletion
51. Physiological role of UCP3 may be export of fatty acids from mitochondria when fatty acid oxidation predominates: An hypothesis
52. Hydroperoxide metabolism in mammalian organs
53. Uncoupling: New approaches to an old problem of bioenergetics
54. A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation
55. Bacterial lipopolysaccharide induces uncoupling protein-2 expression in hepatocytes by a tumor necrosis factor-alpha-dependent mechanism
56. Lipids up-regulate uncoupling protein 2 expression in rat hepatocytes
57. Uncoupling expectations
58. Distinct regulation of brain mitochondrial carrier protein-1 and uncoupling protein-2 genes in the rat brain during cold exposure and aging
59. A plant cold-induced uncoupling protein