GROα/KC, a chemokine receptor CXCR2 ligand, can be a potent trigger for neuronal ERK1/2 and PI-3 kinase pathways and for tau hyperphosphorylation - A role in Alzheimer's disease?

Journal of Neuroimmunology

Volumn 122, Issue 1-2, 2002, Pages 55-64

  Xia, MengQi ^a   Hyman, Bradley T ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Chemokine receptor; CXCR2; ERK1 2; GRO KC; Phosphorylated tau; PI 3 kinase

Indexed keywords

CHEMOKINE RECEPTOR CXCR2; ENZYME ACTIVATOR; LIGAND; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; TAU PROTEIN; ALPHA CHEMOKINE; BORDETELLA VIRULENCE FACTOR; CHEMOTACTIC FACTOR; CXCL1 PROTEIN, HUMAN; CXCL1 PROTEIN, MOUSE; GROWTH PROMOTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MONOCLONAL ANTIBODY; SIGNAL PEPTIDE;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; BRAIN CELL; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENZYME LOCALIZATION; FETUS; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECEPTOR INTRINSIC ACTIVITY; RECEPTOR UPREGULATION; SENILE PLAQUE; ANIMAL; BRAIN CORTEX; CELL CULTURE; CHEMISTRY; CYTOLOGY; DRUG EFFECT; ENCEPHALITIS; ENZYME ACTIVATION; ENZYMOLOGY; HIPPOCAMPUS; IMMUNOLOGY; METABOLISM; NERVE CELL; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ALZHEIMER DISEASE; ANIMALS; ANTIBODIES, MONOCLONAL; CELLS, CULTURED; CEREBRAL CORTEX; CHEMOKINES, CXC; CHEMOTACTIC FACTORS; ENCEPHALITIS; ENZYME ACTIVATION; GROWTH SUBSTANCES; HIPPOCAMPUS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; PHOSPHORYLATION; RECEPTORS, INTERLEUKIN-8B; TAU PROTEINS; VIRULENCE FACTORS, BORDETELLA;

EID: 0036007160     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(01)00463-5     Document Type: Article

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