Synthesis of a novel nitroimidazole-spermidine derivative as a tumor-targeted hypoxia-selective cytotoxin

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 6, 2004, Pages 1519-1522

  Papadopoulou, Maria V ^a   Rosenzweig, Howard S ^a   Bloomer, William D ^a  

^a EVANSTON NORTHWESTERN HEALTHCARE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIN; EFLORNITHINE; MISONIDAZOLE; N 4 [3 (2 NITRO 1 IMIDAZOLYL) 2 HYDROXYPROPYL]SPERMIDINE; NITROIMIDAZOLE DERIVATIVE; POLYAMINE; RADIOSENSITIZING AGENT; UNCLASSIFIED DRUG;

ACTIVE TRANSPORT; ANIMAL CELL; ARTICLE; CHINESE HAMSTER; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; DRUG UPTAKE; HYPOXIA; LUNG FIBROBLAST; NONHUMAN; RADIOSENSITIZATION;

ANIMALS; CELL HYPOXIA; CELL LINE; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; NITROIMIDAZOLES; SPERMIDINE;

EID: 1542314927     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.12.100     Document Type: Article

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