Flupirtine and retigabine prevent L-glutamate toxicity in rat pheochromocytoma PC 12 cells

European Journal of Pharmacology

Volumn 400, Issue 2-3, 2000, Pages 155-166

  Seyfried, Jan ^a   Evert, Bernd O ^b   Rundfeldt, Chris ^c   Schulz, Jörg B ^a   Kovar, Karl A ^a   Klockgether, Thomas ^b   Wüllner, Ullrich ^b  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF BONN   (Germany)

^c Arzneimittelwerk Dresden GmbH   (Germany)

Author keywords

Flupirtine; Glutamate toxicity; Glutathione; PC12 cells; Reactive oxygen intermediates; Retigabine

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING); FLUPIRTINE; GLUTAMIC ACID; LEVODOPA; REACTIVE OXYGEN METABOLITE; RETIGABINE;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL DEATH; CELL STRAIN; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENZYME ACTIVITY; IN VITRO STUDY; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL;

AMINOPYRIDINES; ANALGESICS; ANIMALS; ANTIDEPRESSIVE AGENTS; CARBAMATES; CELL DEATH; CLORGYLINE; CULTURE MEDIA; CYSTINE; DOPAMINE AGENTS; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; GLUTATHIONE; LEVODOPA; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; PC12 CELLS; PHENYLENEDIAMINES; RATS; REACTIVE OXYGEN SPECIES; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0034698341     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00397-6     Document Type: Article

References (62)

1. Ankarcrona M., Dypbukt J.M., Bonfoco E., Zhivotovsky B., Orrenius S., Lipton S.A., Nicotera P. Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron. 15:1995;961-973.
2. Armand V., Rundfeldt C., Heinemann U. Effects of retigabine (D-23129) on different patterns of epileptiform activity induced by 4-aminopyridine in rat entorhinal cortex hippocampal slices. Naunyn-Schmiedeberg's Arch. Pharmacol. 359:1999;33-39.
3. Baker M.A., Cerniglia G.J., Zaman A. Microtiter plate assay for the measurement of glutathione and glutathione disulfide in large numbers of biological samples. Anal. Biochem. 190:1990;360-365.
4. Basma A.N., Heikkila R.E., Nicklas W.J., Giovanni A., Geller H.M. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine- and 1-methyl-4-(2′-ethylphenyl)-1,2,3,6-tetrahydropyridine-induced toxicity in PC12 cells: role of monoamine oxidase A. J. Neurochem. 55:1990;870-877.
5. Beal M.F. Mechanisms of excitotoxicity in neurologic diseases. FASEB J. 6:1992;3338-3344.
6. Block F., Pergande G., Schwarz M. Flupirtine reduces functional deficits and neuronal damage after global ischemia in rats. Brain Res. 754:1997;279-284.
7. Bonfoco E., Krainc D., Ankarcrona M., Nicotera P., Lipton S.A. Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. Proc. Natl. Acad. Sci. U. S. A. 92:1995;7162-7166.
8. Casado M., Lopez-Guajardo A., Mellstrom B., Naranjo J.R., Lerma J. Functional N-methyl-D-aspartate receptors in clonal rat phaeochromocytoma cells. J. Physiol. (London). 490:1996;391-404.
9. Cheung N.S., Pascoe C.J., Giardina S.F., John C.A., Beart P.M. Micromolar L-glutamate induces extensive apoptosis in an apoptotic-necrotic continuum of insult-dependent, excitotoxic injury in cultured cortical neurones. Neuropharmacology. 37:1998;1419-1429.
10. Chihab R., Oillet J., Bossenmeyer C., Daval J.L. Glutamate triggers cell death specifically in mature central neurons through a necrotic process. Mol. Genet. Metab. 63:1998;142-147.
11. Choi D.W. Glutamate neurotoxicity and diseases of the nervous system. Neuron. 1:1988;623-634.
12. Choi D.W. Excitotoxic cell death. J. Neurobiol. 23:1992;1261-1276.
13. Denney R.M., Fritz R.R., Patel N.T., Abell C.W. Human liver MAO-A and MAO-B separated by immunoaffinity chromatography with MAO-B-specific monoclonal antibody. Science. 215:1982;1400-1403.
14. Ferrer I., Martin F., Serrano T., Reiriz J., Perez-Navarro E., Alberch J., Macaya A., Planas A.M. Both apoptosis and necrosis occur following intrastriatal administration of excitotoxins. Acta Neuropathol. 90:1995;504-510.
15. Friedel H.A., Fitton A. Flupirtine. A review of its pharmacological properties, and therapeutic efficacy in pain states. Drugs. 45:1993;548-569.
16. Froissard P., Duval D. Cytotoxic effects of glutamic acid on PC12 cells. Neurochem. Int. 24:1994;485-493.
17. Froissard P., Monrocq H., Duval D. Role of glutathione metabolism in the glutamate-induced programmed cell death of neuronal-like PC12 cells. Eur. J. Pharmacol. 326:1997;93-99.
18. Gassen M., Pergande G., Youdim M.B. Antioxidant properties of the triaminopyridine, flupirtine. Biochem. Pharmacol. 56:1998;1323-1329.
19. Greenamyre J.T., Penney J.B., Young A.B., D'Amato C.J., Hicks S.P., Shoulson I. Alterations in L-glutamate binding in Alzheimer's and Huntington's diseases. Science. 227:1985;1496-1499.
20. Greene L.A., Tischler A.S. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc. Natl. Acad. Sci. U. S. A. 73:1976;2424-2428.
21. Jiang Z.Y., Woollard A.C., Wolff S.P. Hydrogen peroxide production during experimental protein glycation. FEBS Lett. 268:1990;69-71.
22. 2+ block via activation of voltage independent potassium channels. J. Neural Transm. 106:1999;857-867.
23. LeBel C.P., Ischiropoulos H., Bondy S.C. Evaluation of the probe 2′,7′-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress. Chem. Res. Toxicol. 5:1992;227-231.
24. Lees G.J. Contributory mechanisms in the causation of neurodegenerative disorders. Neuroscience. 54:1993;287-322.
25. Lorenz B., Schluter T., Bohnensack R., Pergande G., Muller W.E. Effect of flupirtine on cell death of human umbilical vein endothelial cells induced by reactive oxygen species. Biochem. Pharmacol. 56:1998;1615-1624.
26. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
27. Maher P., Davis J.B. The role of monoamine metabolism in oxidative glutamate toxicity. J. Neurosci. 16:1996;6394-6401.
28. Michaels R.L., Rothman S.M. Glutamate neurotoxicity in vitro: antagonist pharmacology and intracellular calcium concentrations. J. Neurosci. 10:1990;283-292.
29. Muller W.E., Romero F.J., Perovic S., Pergande G., Pialoglou P. Protection of flupirtine on beta-amyloid-induced apoptosis in neuronal cells in vitro: prevention of amyloid-induced glutathione depletion. J. Neurochem. 68:1997;2371-2377.
30. Murphy T.H., Miyamoto M., Sastre A., Schnaar R.L., Coyle J.T. Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress. Neuron. 2:1989;1547-1558.
31. Naoi M., Suzuki H., Takahashi T., Shibahara K., Nagatsu T. Ganglioside GM1 causes expression of type B monoamine oxidase in a rat clonal pheochromocytoma cell line, PC12h. J. Neurochem. 49:1987;1602-1605.
32. Olney J.W. Brain lesions, obesity, and other disturbances in mice treated with monosodium glutamate. Science. 164:1969;719-721.
33. Osborne N.N., Pergande G., Block F., Schwarz M. Immunohistochemical evidence for flupirtine acting as an antagonist on the N-methyl-D-aspartate and homocysteic acid-induced release of GABA in the rabbit retina. Brain Res. 667:1994;291-294.
34. Osborne N.N., Cazevieille C., Pergande G., Wood J.P. Induction of apoptosis in cultured human retinal pigment epithelial cells is counteracted by flupirtine. Invest. Ophthalmol. Visual Sci. 38:1997;1390-1400.
35. Osborne N.N., Cazevieille C., Wood J.P., Nash M.S., Pergande G., Block F., Kosinski C., Schwarz M. Flupirtine, a nonopioid centrally acting analgesic, acts as an NMDA antagonist. Gen. Pharmacol. 30:1998;255-263.
36. Pereira C.M., Oliveira C.R. Glutamate toxicity on a PC12 cell line involves glutathione (GSH) depletion and oxidative stress. Free Radic. Biol. Med. 23:1997;637-647.
37. Pereira C., Santos M.S., Oliveira C. Metabolic inhibition increases glutamate susceptibility on a PC12 cell line. J. Neurosci. Res. 51:1998;360-370.
38. Perovic S., Schleger C., Pergande G., Iskric S., Ushijima H., Rytik P., Muller W.E. The triaminopyridine flupirtine prevents cell death in rat cortical cells induced by N-methyl-D-aspartate and gp120 of HIV-1. Eur. J. Pharmacol. 288:1994;27-33.
39. Perovic S., Schroder H.C., Pergande G., Ushijima H., Muller W.E. Effect of flupirtine on Bcl-2 and glutathione level in neuronal cells treated in vitro with the prion protein fragment (PrP106-126). Exp. Neurol. 147:1997;518-524.
40. Pizzinat N., Copin N., Vindis C., Parini A., Cambon C. Reactive oxygen species production by monoamine oxidases in intact cells. Naunyn-Schmiedeberg's Arch. Pharmacol. 359:1999;428-431.
41. Portera-Cailliau C., Price D.L., Martin L.J. Excitotoxic neuronal death in the immature brain is an apoptosis-necrosis morphological continuum. J. Comp. Neurol. 378:1997;70-87.
42. Portera-Cailliau C., Price D.L., Martin L.J. Non-NMDA and NMDA receptor-mediated excitotoxic neuronal deaths in adult brain are morphologically distinct: further evidence for an apoptosis-necrosis continuum. J. Comp. Neurol. 378:1997;88-104.
43. Re R., Pellegrini N., Proteggente A., Pannala A., Yang M., Rice-Evans C. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic. Biol. Med. 26:1999;1231-1237.
44. Rostock A., Tober C., Rundfeldt C., Bartsch R., Engel J., Polymeropoulos E.E., Kutscher B., Loscher W., Honack D., White H.S., Wolf H.H. D-23129: a new anticonvulsant with a broad spectrum activity in animal models of epileptic seizures. Epilepsy Res. 23:1996;211-223.
45. + channels in neuronal cells. Eur. J. Pharmacol. 336:1997;243-249.
46. + channel opening effect of the anticonvulsant retigabine in PC12 cells. Epilepsy Res. 35:1999;99-107.
47. Rundfeldt C., Netzer R. The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells transfected with human KCNQ2/3 subunits. Neurosci. Lett. 2000;. in press.
48. 2+ concentration. Eur. J. Pharmacol. 294:1995;469-473.
49. Schmidt W.J., Schuster G., Wacker E., Pergande G. AntiParkinsonian and other motor effects of flupirtine alone and in combination with dopaminergic drugs. Eur. J. Pharmacol. 327:1997;1-9.
50. Schubert D., Kimura H., Maher P. Growth factors and vitamin E modify neuronal glutamate toxicity. Proc. Natl. Acad. Sci. U. S. A. 89:1992;8264-8267.
51. Schwarz M., Block F., Pergande G. N-methyl-D-aspartate (NMDA)-mediated muscle relaxant action of flupirtine in rats. NeuroReport. 5:1994;1981-1984.
52. Schwarz M., Nolden-Koch M., Purr J., Pergande G., Block F. AntiParkinsonian effect of flupirtine in monoamine-depleted rats. J. Neural Transm.: Gen. Sect. 103:1996;581-590.
53. Seyfried J., Soldner F., Schulz J.B., Klockgether T., Kovar K.A., Wullner U. Differential effects of L-buthionine sulfoximine and ethacrynic acid on glutathione levels and mitochondrial function in PC12 cells. Neurosci. Lett. 264:1999;1-4.
54. Sohn S., Kim E.Y., Gwag B.J. Glutamate neurotoxicity in mouse cortical neurons: atypical necrosis with DNA ladders and chromatin condensation. Neurosci. Lett. 240:1998;147-150.
55. Soldner F., Weller M., Haid S., Beinroth S., Miller S.W., U W.I., Davis R.E., Dichgans J., Klockgether T., Schulz J.B. MPP+ inhibits proliferation of PC12 cells by a p21(WAF1/Cip1)-dependent pathway and induces cell death in cells lacking p21(WAF1/Cip1). Exp. Cell Res. 250:1999;75-85.
56. Szutowicz A., Kobes R.D., Orsulak P.J. Colorimetric assay for monoamine oxidase in tissues using peroxidase and 2,2′-azinodi(3-ethylbenzthiazoline-6-sulfonic acid) as chromogen. Anal. Biochem. 138:1984;86-94.
57. Tietze F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal. Biochem. 27:1969;502-522.
58. Vaupel D.B., Nickel B., Becketts K. Flupirtine antinociception in the dog is primarily mediated by nonopioid supraspinal mechanisms. Eur. J. Pharmacol. 162:1989;447-456.
59. Walkinshaw G., Waters C.M. Induction of apoptosis in catecholaminergic PC12 cells by L-DOPA. Implications for the treatment of Parkinson's disease. J. Clin. Invest. 95:1995;2458-2464.
60. White H.L., Glassman A.T. Multiple binding sites of human brain and liver monoamine oxidase: substrate specificities, selective inhibitions, and attempts to separate enzyme forms. J. Neurochem. 29:1977;987-997.
61. Yoon K.W., Fuse T., Shah P.T., Nguyen S., Klein M.L. Indirect glutamate neurotoxicity. J. Neurotrauma. 15:1998;141-147.
62. Youdim M.B., Heldman E., Pollard H.B., Fleming P., McHugh E. Contrasting monoamine oxidase activity and tyramine induced catecholamine release in PC12 and chromaffin cells. Neuroscience. 19:1986;1311-1318.