Carcinogens induce genome-wide loss of heterozygosity in normal stem cells without persistent chromosomal instability

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 31, 2006, Pages 11642-11646

  Donahue, Sarah L ^a   Lin, Qing ^a   Cao, Shang ^a   Ruley, H Earl ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cancer etiology; Cancer genetics; Carcinogenesis; Genome stability

Indexed keywords

BUTADIENE DIEPOXIDE; CARCINOGEN; DNA; DOXORUBICIN; HYDROXYUREA; METHYLNITROSOUREA; MITOMYCIN C; MUTAGENIC AGENT;

ANIMAL CELL; ARTICLE; BLOOM SYNDROME; CANCER; CANCER GENETICS; CARCINOGENICITY; CHROMOSOMAL INSTABILITY; DIPLOIDY; DNA REPAIR; EMBRYO; EMBRYONIC STEM CELL; GENE LOCUS; GENE MUTATION; GENETIC SCREENING; GENOMIC INSTABILITY; GENOTOXICITY; HETEROZYGOSITY LOSS; HOMOZYGOTE; MOUSE; NONHUMAN; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; RECESSIVE INHERITANCE; ULTRAVIOLET IRRADIATION;

ANIMALS; CARCINOGENS; CELL LINE; CHROMOSOMAL INSTABILITY; GENOME; GENOTYPE; HUMANS; LOSS OF HETEROZYGOSITY; MICE; MUTATION; NEOPLASMS; PHENOTYPE; STEM CELLS;

MAMMALIA;

EID: 33746835007     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0510741103     Document Type: Article

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