How many mutations in a cancer?

American Journal of Pathology

Volumn 160, Issue 3, 2002, Pages 755-758

  Tomlinson, Ian ^a   Sasieni, Peter ^a   Bodmer, Walter ^b  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOGENESIS; CELL DEATH; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CLONE; GENE MUTATION; MATHEMATICAL ANALYSIS; MOLECULAR MODEL; NOTE; PRIORITY JOURNAL; STEM CELL; TUMOR GROWTH;

EID: 0036118250     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64896-1     Document Type: Note

References (13)

1. Genetic instabilities in human cancers
2. Selection, the mutation rate, and cancer: Ensuring that the tail does not wag the dog
3. A mutator phenotype in cancer
4. Mutations of mitotic checkpoint genes in human cancers
5. Microsatellite instability in cancer of the proximal colon
6. Allelotype of human ovarian cancer
7. The onset and extent of genomic instability in sporadic colorectal tumor progression
8. Microsatellite instability in adenomas as a marker for hereditary nonpolyposis colorectal cancer
9. Detection of DNA copy number changes in human endometriosis by comparative genomic hybridization
10. How many mutations does it take to make a tumor?
11. Significance of multiple mutations in cancer
12. Failure of programmed cell death and differentiation as causes of tumors: Some simple mathematical models
13. Digital PCR