Calderón encodes an organic cation transporter of the major facilitator superfamily required for cell growth and proliferation of Drosophila tissues

Development

Volumn 133, Issue 14, 2006, Pages 2617-2625

  Herranz, Héctor ^a,b   Morata, Ginés ^b   Milán, Marco ^a  

^a INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

^b CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOA   (Spain)

Author keywords

Drosophila; Growth; Insulin pathway; Wing

Indexed keywords

INSULIN RECEPTOR; ORGANIC CATION TRANSPORTER; SUGAR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DROSOPHILA; EXPERIMENTAL STUDY; GENE IDENTIFICATION; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; LARVA; MODULATION; NONHUMAN; NUTRIENT; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; SEQUENCE HOMOLOGY; SUGAR TRANSPORT; TISSUE GROWTH;

AMINO ACID SEQUENCE; ANIMALS; CELL PROLIFERATION; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EMBRYONIC STRUCTURES; HUMANS; INSULIN; MOLECULAR SEQUENCE DATA; ORGANIC CATION TRANSPORT PROTEINS; PHENOTYPE; RECEPTOR, INSULIN; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, NUCLEIC ACID; SIGNAL TRANSDUCTION;

EID: 33746809397     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: 10.1242/dev.02436     Document Type: Article

References (45)

1. Azpiazu, N. and Frasch, M. (1993). tinman and bagpipe: two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila. Genes Dev. 7, 1325-1340.
2. Beck, T. and Hall, M. N. (1999). The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors. Nature 402, 689-692.
3. Böhni, R., Riesgo-Escovar, J., Oldham, S., Brogiolo, W., Stocker, H., Andruss, B. F., Beckingham, K. and Hafen, E. (1999). Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4. Cell 97, 865-875.
4. Brand, A. H. and Perrimon, N. (1993). Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401-415.
5. Bulter, A. A. and Le Roith, D. (2001). Control of growth by the somatropic axis: growth hormone and the insulin-like growth factors have related and independent roles. Annu. Rev. Physiol. 63, 141-164.
6. Calleja, M., Moreno, E., Pelaz, S. and Morata, G. (1996). Visualization of gene expression in living adult Drosophila. Science 274, 252-255.
7. Cardenas, M. E., Cutler, N. S., Lorenz, M. C., Di Como, C. J. and Heitman, J. (1999). The TOR signaling cascade regulates gene expression in response to nutrients. Genes Dev. 13, 3271-3279.
8. Castelli-Gair, J., Greig, S., Micklem, G. and Akam, M. (1994). Dissecting the temporal requirements for homeotic gene function. Development 120, 1983-1995.
9. Coelho, C. M. and Leevers, S. J. (2000). Do growth and cell division rates determine cell size in multicellular organisms? J. Cell Sci. 113, 2927-2934.
10. Conlon, I. and Raff, M. (1999). Size control in animal development. Cell 96, 235-244.
11. Efstratiadis, A. (1998). Genetics of mouse growth. Int. J. Dev. Biol. 42, 955-976.
12. Entingh, A. J., Law, B. K. and Moses, H. L. (2001). Induction of the C/ EBP homologous protein (CHOP) by amino acid deprivation requires insulin-like growth factor I, phosphatidylinositol 3-kinase, and mammalian target of rapamycin signaling. Endocrinology 142, 221-228.
13. Fernandez, R., Tabarini, D., Azpiazu, N., Frasch, M. and Schlessinger, J. (1995). The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potential. EMBO J. 14, 3373-3384.
14. Frank, L. H. and Rushlow, C. (1996). A group of genes required for maintenance of the amnioserosa tissue in Drosophila. Development 122, 1343-1352.
15. Fraser, A. G., McCarthy, N. J. and Evan, G. I. (1997). drICE is an essential caspase required for apoptotic activity in Drosophila cells. EMBO J. 16, 6192-6199.
16. Garami, A., Zwartkruis, F. J., Nobukuni, T., Joaquin, M., Roccio, M., Stocker, H., Kozma, S. C., Hafen, E., Bos, J. L. and Thomas, G. (2003). Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol. Cell 11, 1457-1466.
17. Goberdhan, D. C. and Wilson, C. (2003). The functions of insulin signaling: size isn't everything, even in Drosophila. Differentiation 71, 375-397.
18. Grundemann, D., Harlfinger, S., Golz, S., Geerts, A., Lazar, A., Berkels, R., Jung, N., Rubbert, A. and Schomig, E. (2005). Discovery of the ergothioneine transporter. Proc. Natl. Acad. Sci. USA 102, 5256-5261.
19. Hay, B. A., Wassarman, D. A. and Rubin, G. M. (1995). Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death. Cell 83, 1253-1262.
20. Herranz, H. and Morata, G. (2001). The functions of pannier during Drosophila embryogenesis. Development 128, 4837-4846.
21. Jazwinska, A., Kirov, N., Wieschaus, E., Roth, S. and Rushlow, C. (1999). The Drosophila gene brinker reveals a novel mechanism of Dpp target gene regulation. Cell 96, 563-573.
22. Junger, M. A., Rintelen, F., Stocker, H., Wasserman, J. D., Vegh, M., Radimerski, T., Greenberg, M. E. and Hafen, E. (2003). The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. J. Biol. 2, 20.
23. Kramer, J. M., Davidge, J. T., Lockyer, J. M. and Staveley, B. E. (2003). Expression of Drosophila FOXO regulates growth and can phenocopy starvation. BMC Dev. Biol. 3, 5.
24. Lee, T. and Luo, L. (1999). Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis. Neuron 22, 451-461.
25. Leevers, S. J., Weinkove, D., MacDougall, L. K., Hafen, E. and Waterfield, M. D. (1996). The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth. EMBO J. 15, 6584-6594.
26. Milan, M., Diaz-Benjumea, F. J. and Cohen, S. M. (1998). Beadex encodes an LMO protein that regulates Apterous LIM-homeodomain activity in Drosophila wing development: a model for LMO oncogene function. Genes Dev. 12, 2912-2920.
27. Morata, G. and Ripoll, P. (1975). Minutes: mutants of Drosophila autonomously affecting cell division rate. Dev. Biol. 42, 211-221.
28. Moreno, E., Basler, K. and Morata, G. (2002). Cells compete for decapentaplegic survival factor to prevent apoptosis in Drosophila wing development. Nature 416, 755-759.
29. Neufeld, T. P. (2003). Body building: regulation of shape and size by PI3K/TOR signaling during development. Mech. Dev. 120, 1283-1296.
30. Peltekova, V. D., Wintle, R. F., Rubin, L. A., Amos, C. I., Huang, Q., Gu, X., Newman, B., Van Oene, M., Cescon, D., Greenberg, G. et al. (2004). Functional variants of OCTN cation transporter genes are associated with Crohn disease. Nat. Genet. 36, 471-475.
31. Puig, O., Marr, M. T., Ruhf, M. L. and Tjian, R. (2003). Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway. Genes Dev. 17, 2006-2020.
32. Roesler, W. J. (2001). The role of C/EBP in nutrient and hormonal regulation of gene expression. Annu. Rev. Nutr. 21, 141-165.
33. Rulifson, E. J., Kim, S. K. and Nusse, R. (2002). Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes. Science 296, 1118-1120.
34. Saucedo, L. J., Gao, X., Chiarelli, D. A., Li, L., Pan, D. and Edgar, B. A. (2003). Rheb promotes cell growth as a component of the insulin/TOR signalling network. Nat. Cell Biol. 5, 566-571.
35. Shioi, T., Kang, P. M., Douglas, P. S., Hampe, J., Yballe, C. M., Lawitts, J., Cantley, L. C. and Izumo, S. (2000). The conserved phosphoinositide 3-kinase pathway determines heart size in mice. EMBO J. 19, 2537-2548.
36. Shioi, T., McMullen, J. R., Kang, P. M., Douglas, P. S., Obata, T., Franke, T. F., Cantley, L. C. and Izumo, S. (2002). Akt/protein kinase B promotes organ growth in transgenic mice. Mol. Cell. Biol. 22, 2799-2809.
37. Stern, D. L. and Emlen, D. J. (1999). The developmental basis for allometry in insects. Development 126, 1091-1101.
38. Stocker, H. and Hafen, E. (2000). Genetic control of cell size. Curr. Opin. Genet. Dev. 10, 529-535.
39. Stocker, H., Radimerski, T., Schindelholz, B., Wittwer, F., Belawat, P., Daram, P., Breuer, S., Thomas, G. and Hafen, E. (2003). Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. Nat. Cell Biol. 5, 559-565.
40. Tabata, T., Schwartz, C., Gustavson, E., Ali, Z. and Kornberg, T. B. (1995). Creating a Drosophila wing de novo: the role of engrailed and the compartment border hypothesis. Development 121, 3359-3369.
41. Tautz, D. and Pfeifle, C. (1989). A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. Chromosoma 98, 81-85.
42. Tokuhiro, S., Yamada, R., Chang, X., Suzuki, A., Kochi, Y., Sawada, T., Suzuki, M., Nagasaki, M., Ohtsuki, M., Ono, M. et al. (2003). An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis. Nat. Genet. 35, 341-348.
43. Wilder, E. L. and Perrimon, N. (1995). Dual functions of wingless in the Drosophila leg imaginal disc. Development 121, 477-488.
44. Xu, T. and Rubin, G. M. (1993). Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117, 1223-1237.
45. Zhang, Y., Gao, X., Saucedo, L. J., Ru, B., Edgar, B. A. and Pan, D. (2003). Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nat. Cell Biol. 5, 578-581.