The role of C/EBP in nutrient and hormonal regulation of gene expression

Annual Review of Nutrition

Volumn 21, Issue , 2001, Pages 141-165

  Roesler, W J ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

cAMP; Phosphoenolpyruvate carboxykinase; Phosphorylation; Transcription factor

Indexed keywords

CYCLIC AMP; GLUCOCORTICOID; PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP); THYROID HORMONE; TRANSCRIPTION FACTOR;

DNA BINDING; ENERGY METABOLISM; GENE CONTROL; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HORMONAL REGULATION; NUTRIENT; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; REVIEW; TRANSACTIVATION;

CCAAT-ENHANCER-BINDING PROTEINS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; ENERGY METABOLISM; GENE EXPRESSION REGULATION; GLUCOCORTICOIDS; HORMONES; HUMANS; NUTRITION PHYSIOLOGY; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PHOSPHORYLATION; PROTEIN ISOFORMS; TRANSCRIPTION, GENETIC;

EID: 0034943544     PISSN: 01999885     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.nutr.21.1.141     Document Type: Review

References (112)

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2. A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family
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4. The C/EBP family of proteins distorts DNA upon binding but does not introduce a large directed bend
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7. Involvement of a C/EBP-like protein in the acquisition of responsiveness to glucocorticoid hormones during chick neural retina development
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9. Insulin inhibits liver expression of the CCAAT/enhancer-binding proteinβ
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11. Amino acid limitation induces expression of CHOP, a CCAAT/enhancer binding protein-related gene, at both transcriptional and post-transcriptional levels
12. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells
13. Molecular cloning of a transcription factor, AGP/EBP, that belongs to members of the C/EBP family
14. Antioxidant-induced nuclear translocation of CCAAT/enhancer-binding protein α
15. CAAT/enhancer binding proteins directly modulate transcription from the peroxisome proliferator-activated receptor γ 2 promoter
16. Ig/EBP (C/EBPγ) is a transdominant negative inhibitor of C/EBP family transcriptional activators
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21. LAP, a novel member of the C/EBP family, encodes a liver-enriched transcriptional activator protein
22. Identification of two polypeptide segments of CCAAT/enhancer-binding protein required for transcriptional activation of the serum albumin gene
23. Context-dependent transcriptional regulation
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25. A c-erb-A binding site in rat growth hormone gene mediates trans-activation by thyroid hormone
26. Phosphoenolpyruvate carboxykinase (GTP): The gene and the enzyme
27. Signaling pathways through which insulin regulates CCAAT/enhancer binding protein α (C/EBPα) phosphorylation and gene expression in 3T3-L1 adipocytes
28. Functional antagonism between CCAAT/-enhancer binding protein-α and peroxisome proliferator-activated receptor-γ on the leptin promoter
29. Transcriptional activation of the mouse obese (ob) gene by CCAAT/enhancer binding protein α
30. Glucocorticoid receptor-cAMP response element binding protein interaction and the response of the phosphoenolpyruvate carboxykinase gene to glucocorticoids
31. CCAAT/ enhancer-binding protein α is a physiological regulator of prolactin gene expression
32. Identification of C/EBP basic region residues involved in DNA sequence recognition and half-site spacing preference
33. Amino acid regulation of gene expression
34. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors
35. The NF-M transcription factor is related to C/EBPβ and plays a role in signal transduction, differentiation and leukemogenesis of avian myelomonocytic cells
36. Diversity and specificity in transcriptional regulation: The benefits of heterotypic dimerization
37. cAMP stimulates transcription of the gene for cytosolic phosphoenolpyruvate carboxykinase in rat liver nuclei
38. The leucine zipper: A hypothetical structure common to a new class of DNA binding proteins
39. Disruption of the c/ebpα gene in adult mouse liver
40. High level activity of the mouse CCAAT/enhancer binding protein (C/EBPα) gene promoter involves autoregulation and several ubiquitous transcription factors
41. Biological role of the CCAAT/enhancer-binding protein family of transcription factors
42. CCAAT/enhancer-binding protein β (C/EBPβ) and C/EBPδ contribute to growth hormone-regulated transcription of c-fos
43. Antisense CCAAT/enhancer-binding protein RNA suppresses coordinate gene expression and triglyceride accumulation during differentiation of 3T3-L1 preadipocytes
44. Cyclic AMP induction of phosphoenolpyruvate carboxykinase (GTP) gene transcription is mediated by multiple promoter elements
45. Hypoglycemia and impaired hepatic glucose production in mice with a deletion of the C/EBPβ gene
46. Thyroid hormone regulates transcription of the gene for cytosolic phosphoenolpyruvate carboxykinase (GTP) in rat liver
47. Hormone response domains in gene transcription
48. Glucocorticoids reciprocally regulate expression of the CCAAT/enhancer-binding protein α and δ genes in 3T3-L1 adipocytes and white adipose tissue
49. Insulin regulates transcription of the CCAAT/enhancer binding (C/EBP) α, β, and δ genes in fully-differentiated 3T3-L1 adipocytes
50. Phosphorylation of CCAAT-enhancer binding protein by protein kinase C attenuates site-selective DNA binding
51. Cell-specific regulation of IRS-1 gene expression
52. Induction of the C/EBPβ gene by dexamethasone and glucagon in primary-cultured rat hepatocytes
53. Is CCAAT/enhancer-binding protein α central regulator of energy metabolism?
54. Effect of hormones on transcription of the gene for cytosolic phosphoenolpyruvate carboxykinase (GTP) in rat kidney
55. cAMP stimulates the C/EBP-related transcription factor rNFIL-6 to trans-locate to the nucleus and induce c-fos transcription
56. Interaction and functional collaboration of p300 and C/EBPβ
57. Integration of multiple signals through a complex hormone response unit in the phosphoenolpyruvate carboxykinase gene promoter
58. Life without white fat: A transgenic mouse
59. Binding of a nuclear protein to the cyclic AMP response element of the somatostatin gene
60. A novel, myeloid transcription factor, C/EBPε, is upregulated during granulocytic, but not monocytic, differentiation
61. 3,5,3′-Triiodothyronine-induced synthesis of rat liver phosphoenolpyruvate carboxykinase
62. Phosphorylation of threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6
63. Three levels of functional interaction determine the activity of CCAAT/enhancer binding protein-α on the serum albumin promoter
64. CCAAT/enhancer binding protein-α amino acid motifs with dual TBP and TFIIB binding ability cooperate to activate transcription in both yeast and mammalian cells
65. CREB controls LAP/C/EBPβ transcription
66. A nuclear factor for interleukin-6 expression (NF-IL6) and the glucocorticoid receptor synergistically activate transcription of the rat α 1-acid glycoprotein gene via direct protein-protein interaction
67. Involvement of transcription factor C/EBP-β in stimulation of PEPCK gene expression during exercise
68. Design of a C/EBP-specific, dominant-negative bZIP protein with both inhibitory and gain-of-function properties
69. Regulation of phosphoenolpyruvate carboxykinase gene transcription by thyroid hormone involves two distinct binding sites in the promoter
70. The role of the CCAAT/enhancer-binding protein in the transcriptional regulation of the gene for phosphoenolpyruvate carboxykinase (GTP)
71. CCAAT-enhancer-binding protein a (C/EBPα) is required for the thyroid hormone but not the retinoic acid induction of phosphoenolpyruvate carboxykinase (PEPCK) gene transcription
72. Role of CCAAT enhancer-binding protein β in the thyroid hormone and cAMP induction of phosphoenolpyruvate carboxykinase gene transcription
73. An "attenuator domain" is sandwiched by two distinct transactivation domains in the transcription factor C/EBP
74. IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to C/EBP
75. Glucocorticoid-stimulated CCAAT/enhancer-binding protein α expression is required for steroid-induced G1 cell cycle arrest of minimal-deviation rat hepatoma cells
76. What is a cAMP response unit?
77. The α-isoform of the CCAAT/enhancer-binding protein is required for mediating the cAMP responsiveness of the phosphoenolpyruvate carboxykinase promoter in hepatoma cells
78. The cAMP response element binding protein synergizes with other transcription factors to mediate cAMP responsiveness
79. Evidence for the involvement of at least two distinct transcription factors, one of which is liver-enriched, for the activation of the phosphoenolpyruvate carboxykinase gene promoter by cAMP
80. Hormone response units: One plus one equals more than two
81. Characterization of CCAAT/enhancer-binding protein α as a cyclic AMP-responsive nuclear regulator
82. Characterization of the liver-specific component of the cAMP response unit in the phosphoenolpyruvate carboxykinase (GTP) gene promoter
83. Cyclic AMP and the induction of eukaryotic gene transcription
84. CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription
85. Glycogen synthase kinase 3 is an insulin-regulated C/EBPα kinase
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88. Lymphoproliferative disorder and imbalanced T-helper response in C/EBP beta-deficient mice
89. CREB: A stimulus-induced transcription factor activated by a diverse array of extracellular signals
90. Characterization of the phosphoenolpyruvate carboxykinase (GTP) promoter-regulatory region. II. Identification of cAMP and glucocorticoid regulatory domains
91. Rate of synthesis and degradation of rat liver phosphoenolpyruvate carboxykinase in the different thyroid states
92. An essential role for C/EBPβ in female reproduction
93. A multicomponent insulin response sequence mediates a strong repression of mouse glucose-6-phosphatase gene transcription by insulin
94. Induction of GADD153, a CCAAT/enhancer-binding protein (C/EBP)-related gene, during the acute phase response in rats
95. cAMP activation of CAAT enhancer-binding protein-β gene expression and promoter I of acetyl-CoA carboxylase
96. Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages
97. Defective adipocyte differentiation in mice lacking the C/EBPβ and/or C/EBPδ gene
98. Autoregulation of the human C/EBPα gene by stimulation of upstream stimulatory factor binding
99. Metabolic regulation of gene transcription in mammals
100. Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain
101. C/EBP-β/LAP controls down-regulation of albumin gene transcription during liver regeneration
102. Protein kinase A and C site-specific phosphorylation of LAP (NF-IL6) modulate its binding affinity to DNA recognition elements
103. Transactivation of LAP/NF-IL6 is mediated by an acidic domain in the N-terminal part of the protein
104. Impaired energy homeostasis in C/EBP alpha knockout mice
105. Modulation of CCAAT/enhancer-binding protein-α gene expression by metabolic signals in rodent adipocytes
106. Calcium-regulated phosphorylation within the leucine zipper of C/EBPβ
107. CRP2 (C/EBPβ) contains a bipartite regulatory domain that controls transcriptional activation, DNA binding and cell specificity
108. A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro
109. CCAAT/enhancer-binding protein β is an accessory factor for the glucocorticoid response from the cAMP response element in the rat phosphoenolpyruvate carboxykinase gene promoter
110. Characterization of elements mediating regulation of phosphoenolpyruvate carboxykinase gene transcription by protein kinase A and insulin
111. Tumor necrosis factor a promotes nuclear localization of cytokine-inducible CCAAT/enhancer binding protein isoforms in hepatocytes