Precursor directed biosynthesis of novel 6-deoxyerythronolide B analogs containing non-natural oxygen substituents and reactive functionalities

Tetrahedron Letters

Volumn 40, Issue 4, 1999, Pages 635-638

  Hunziker, Daniel ^a   Wu, Nicholas ^b   Kenoshita, Kenji ^c   Cane, David E ^c   Khosla, Chaitan ^a,b  

^a Stanford University   (United States)

^b STANFORD UNIVERSITY   (United States)

^c BROWN UNIVERSITY   (United States)

Author keywords

Blocked mutant; Evans aldol reaction; Polyketides; Precursor directed biosynthesis

Indexed keywords

6 DEOXYERYTHRONOLIDE B; ERYTHRONOLIDE B; ERYTHRONOLIDE DERIVATIVE; OXYGEN; POLYKETIDE; SYNTHETASE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS;

EID: 0033593567     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(98)02507-6     Document Type: Article

References (16)

1. Abbreviations used: 6-dEB: 6-deoxyerythronolide B; DEBS: 6-dEB Synthase; DIBAH: diisobutylaluminium hydride; DIEA: diisopropylethylamine; KS: keto synthase; PKS: polyketide synthase; NAC: N-acetylcysteamine; TBDMS: t-butyldimethylsilyl.
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14. 3).
15. +: 385.2590. Found: 385.2580.
16. +: 259.0. Found: 259.0.