p16INK4a gene alterations are frequent in lesions of mycosis fungoides

American Journal of Pathology

Volumn 156, Issue 5, 2000, Pages 1565-1572

  Navas, Inmaculada C ^a   Ortiz Romero, Pablo L ^b   Villuendas, Raquel ^a   Martínez, Pedro ^a   García, Carmen ^a   Gómez, Enrique ^b   Rodriguez, Jose L ^b   García, Domingo ^b   Vanaclocha, Francisco ^b   Iglesias, Luis ^b   Piris, Miguel A ^b   Algara, Patrocinio ^a  

^a HOSPITAL VIRGEN DE LA SALUD   (Spain)

^b HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P16;

ADULT; AGED; ALLELE; ARTICLE; CONTROLLED STUDY; CPG ISLAND; DISEASE COURSE; FEMALE; GENE DELETION; GENE FREQUENCY; GENE INACTIVATION; GENE LOSS; GENE MUTATION; GENE SILENCING; HUMAN; HUMAN TISSUE; MALE; METHYLATION; MYCOSIS FUNGOIDES; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

EID: 0033843331     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)65028-6     Document Type: Article

References (33)

1. Cutaneous T-cell lymphoma: Mycosis fungoides, Sezary syndrome and other variants
2. Mycosis fungoides and Sezary syndrome
3. The turmour suppresser protein p16(INK4a)
4. Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers
5. Rates of p16 (MTS1) mutations in primary tumors with 9p loss
6. Role of the p16 tumour suppresser gene in cancer
7. Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers
8. 5'CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
9. Loss of p16/INK4A protein expression in non-Hodgkin's lymphomas is a frequent finding associated with tumor progression
10. Homozygous deletions at chromosome 9p21 involving p16 and p15 are associated with histologic progression in follicle centre lymphoma
11. p16(INK4a) gene inactivation by deletions, mutations and hypermethylation is associated with transformed and aggressive variants of non-Hodgkin's lymphomas
12. Hypermethylation of a 5'CpG island of p16 is a frequent event in non-Hodgkin's lymphoma
13. CDKN2 (MTS1/p16(INK4a)) gene alterations in adult T-cell leukemia/lymphoma
14. CDKN2 (MTS1/p16(INK4a)) gene alterations in hematological malignancies
15. Frequent methylation silencing of p15(INK4ab) (MTS2) and p16(INK4a) (MTS1) in B-cell and T-cell lymphomas
16. p53 Oncoprotein expression in cutaneous lymphoproliferations
17. p53 immunoreactivity is uncommon in primary cutaneous lymphoma
18. Infrequent expression of protein p53 in epidermotropic variants of cutaneous T-cell lymphomas
19. bcl1, bcl2, p53, c-myc and lyt10 analysis in cutaneous lymphomas
20. Overexpression of p53 protein in cutaneous T-cell lymphoma: Relationship to large cell transformation and disease progression
21. Review of alterations of the cyclin dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia-lymphoma cells
22. Codeletion of CDKN2 and MTAP genes in a subset of non-Hodgkin lymphomas may be associated with histologic transformation from low-grade to diffuse large-cell lymphoma
23. Deletions and rearrangement of CDKN2 in lymphoid malignancy
24. Loss of the cyclin-dependent kinase 4-inhibitor (p16;MTS1) gene is frequent in and highly specific to lymphoid tumors in primary human hematopoietic malignancies
25. Deletions of the cyclin-dependent kinase inhibitor genes p16tNK4A and p151NK4B in non-Hodgkin's lymphomas
26. Homozygous loss of the MTS1/p16 and MTS2/p15 genes in lymphoma and lymphoblastic leukaemia cell lines
27. Reduced expression of CDKN2a/p16(INK4a) in mycosis fungoides
28. Frequency of homozygous deletion at p16/CDKN2 in primary human tumours
29. Methylarich-specific PCR: A novel PCR assay for methylation status of CpG islands
30. A cell cycle regulator potentially involved in genesis of many type of tumors
31. Methylation of the 5'CpG island of the p16/CDKN2 tumour suppresser gene in normal and transformed human tissues correlates with gene silencing
32. Distinct patterns of inactivation of p15(INK4b) and p16(INK4a) characterize the major types of hematological malignancies
33. Frequent hypermethylation of p16 and p15 genes in multiple myeloma