Transcriptional regulation by p53 and p73

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 70, Issue , 2005, Pages 121-128

  Lokshin, M ^a   Tanaka, T ^a   Prives, C ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; PROTEIN P73; PROTEIN P21; TUMOR PROTEIN P73;

APOPTOSIS; CELL CYCLE ARREST; CONFERENCE PAPER; CONTROLLED STUDY; DNA DAMAGE; GENE ACTIVATION; GENE ACTIVITY; GENE EXPRESSION; GENE FUNCTION; GENE TARGETING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE; ARTICLE; CANCER SUSCEPTIBILITY; CHROMATIN IMMUNOPRECIPITATION; DOWN REGULATION; FLUORESCENCE ACTIVATED CELL SORTING; IMMUNOBLOTTING; IMMUNOPRECIPITATION; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

APOPTOSIS REGULATORY PROTEINS; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA DAMAGE; DNA-BINDING PROTEINS; HUMANS; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); TRANS-ACTIVATION (GENETICS); TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 33746470711     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.2005.70.046     Document Type: Conference Paper

References (38)

1. Agami R., Blandino G., Oren M., and Shaul Y. 1999. Interaction of c-Abl and p73á and their collaboration to induce apoptosis. Nature 399: 809.
2. Appella E. and Anderson C.W. 2001. Post-translational modifications and activation of p53 by genotoxic stresses. Eur. J. Biochem. 268: 2764.
3. Attardi L.D. and Jacks T. 1999. The role of p53 in tumour suppression: Lessons from mouse models. Cell Mol. Life Sci. 55: 48.
4. Bates S. and Vousden K.H. 1999. Mechanisms of p-53-mediated apoptosis. Cell Mol. Life Sci. 55: 28.
5. Chen X., Ko L.J., Jayaraman L., and Prives C. 1996. p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells. Genes Dev. 10: 2438.
6. Costanzo A., Merlo P., Pediconi N., Fulco M., Sartorelli V., Cole P.A., Fontemaggi G., Fanciulli M., Schiltz L., Blandino G., Balsano C., and Levrero M. 2002. DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes. Mol. Cell 9: 175.
7. Donehower L.A., Harvey M., Slagle B.L., McArthur M.J., Montgomery C.A., Jr., Butel J.S., and Bradley A. 1992. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356: 215.
8. Gu W. and Roeder R.G. 1997. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 90: 595.
9. Harms K., Nozell S., and Chen X. 2004. The common and distinct target genes of the p53 family transcription factors. Cell Mol. Life Sci. 61: 822.
10. Irwin M.S. and Kaelin W.G., Jr. 2001a. p53 family update: p73 and p63 develop their own identities. Cell Growth Differ. 12: 337.
11. _. 2001b. Role of the newer p53 family proteins in malignancy. Apoptosis 6: 17.
12. Irwin M.S., Kondo K., Marin M.C., Cheng L.S., Hahn W.C., and Kaelin W.G., Jr. 2003. Chemosensitivity linked to p73 function. Cancer Cell 3: 403.
13. Jost C.A., Marin M.C., and Kaelin W.G., Jr. 1997. p73 is a simian [correction of human] p53-related protein that can induce apoptosis. Nature 389: 191.
14. Kaeser M.D. and Iggo R.D. 2002. Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo. Proc. Natl. Acad. Sci. 99: 95.
15. Kaghad M., Bonnet H., Yang A., Creancier L., Biscan J.C., Valent A., Minty A., Chalon P., Lelias J.M., Dumont X., Ferrara P., McKeon F., and Caput D. 1997. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell 90: 809.
16. Ko L.J. and Prives C. 1996. p53: Puzzle and paradigm. Genes Dev. 10: 1054.
17. Lee C.W. and La Thangue N.B. 1999. Promoter specificity and stability control of the p53-related protein p73. Oncogene 18: 4171.
18. Levine A.J. 1997. p53, the cellular gatekeeper for growth and division. Cell 88: 323.
19. Lin K.W., Nam S.Y., Toh W.H., Dulloo I., and Sabapathy K. 2004. Multiple stress signals induce p73β accumulation. Neoplasia 6: 546.
20. Liu G. and Chen X. 2005. The C-terminal sterile alpha motif and the extreme C terminus regulate the transcriptional activity of the alpha isoform of p73. J. Biol. Chem. 280: 20111.
21. Ludwig R.L., Bates S., and Vousden K.H. 1996. Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function. Mol. Cell. Biol. 16: 4952.
22. Moll U.M. and Petrenko O. 2003. The MDM2-p53 interaction. Mol. Cancer Res. 1: 1001.
23. Moll U.M. and Slade N. 2004. p63 and p73: Roles in development and tumor formation. Mol. Cancer Res. 2: 371.
24. Oda K., Arakawa H., Tanaka T., Matsuda K., Tanikawa C., Mori T., Nishimori H., Tamai K., Tokino T., Nakamura Y., and Taya Y. 2000. p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell 102: 849.
25. Ozaki T., Naka M., Takada N., Tada M., Sakiyama S., and Nakagawara A. 1999. Deletion of the COOH-terminal region of p73α enhances both its trans-activation function and DNA-binding activity but inhibits induction of apoptosis in mammalian cells. Cancer Res. 59: 5902.
26. Poyurovsky M.V. and Prives C. 2006. Unleashing the power of p53: Lessons from mice and men. Genes Dev. 20: 125. (11)
27. Prives C. and Hall P.A. 1999. The p53 pathway. J. Pathol. 187: 112.
28. Sakaguchi K., Herrera J.E., Saito S., Miki T., Bustin M., Vassilev A., Anderson C.W., and Appella E. 1998. DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev. 12: 2831.
29. Samuels-Lev Y., O'Connor D.J., Bergamaschi D., Trigiante G., Hsieh J.K., Zhong S., Campargue I., Naumovski L., Crook T., and Lu X. 2001. Mol. Cell 8: 781.
30. Shieh S.Y., Ikeda M., Taya Y., and Prives C. 1997. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell 91: 325.
31. Szak S.T., Mays D., and Pietenpol J.A. 2001. Kinetics of p53 binding to promoter sites in vivo. Mol. Cell. Biol. 21: 3375.
32. Ueda Y., Hijikata M., Takagi S., Chiba T., and Shimotohno K. 1999. New p73 variants with altered C-terminal structures have varied transcriptional activities. Oncogene 18: 4993.
33. Urist M., Tanaka T., Poyurovsky M.V., and Prives C. 2004. p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2. Genes Dev. 18: 3041.
34. Wang Y. and Prives C. 1995. Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases. Nature 376: 88.
35. Yang A., Kaghad M., Caput D., and McKeon F. 2002. On the shoulders of giants: p63, p73 and the rise of p53. Trends Genet. 18: 90.
36. Yang A., Walker N., Bronson R., Kaghad M., Oosterwegel M., Bonnin J., Vagner C., Bonnet H., Dikkes P., Sharpe A., McKeon F., and Caput D. 2000. p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours. Nature 404: 99.
37. Yuan Z.M., Shioya H., Ishiko T., Sun X., Gu J., Huang Y.Y., Lu H., Kharbanda S., Weichselbaum R., and Kufe D. 1999. p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage. Nature 399: 814.
38. Zhu J., Jiang J., Zhou W., and Chen X. 1998. The potential tumor suppressor p73 differentially regulates cellular p53 target genes. Cancer Res. 58: 5061.