Application of rabbits in biomedical research: A review

World Rabbit Science

Volumn 14, Issue 1, 2006, Pages 1-14

  Bosze Zs ^a   Houdebine, L M ^b  

^a SZENT ISTVÁN UNIVERSITY   (Hungary)

^b INRA Institut National de la Recherche Agronomique   (France)

Author keywords

Bioreactor; Human disease model; Rabbit; Vaccines

Indexed keywords

ANIMALIA; MAMMALIA; MUS MUSCULUS; ORYCTOLAGUS CUNICULUS; RODENTIA;

EID: 33746379562     PISSN: 12575011     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (100)

1. Apostel F., Dammann R., Pfeifer G.P., Greeve J. 2002. Reduced expression and increased CpG dinucleotide methylation of the rat APOBEC-1 promoter in transgenic rabbits. Biochim Biophys Acta., 1577, 384-94.
2. Araki M., Fan J.L., Challah M., Bensaudon A., Yamada N., Honda K., 2000. Transgenic rabbits expressing human lipoprotein lipase Cytotechnology, 33, 93-99.
3. Baranyi M., Brignon G., Anglage P., Ribadeau-Dumas B. 1995. New data on the proteins of rabbit (Oryctolagus cuniculus) milk. Comp Biochem Physiol B Biochem Mol Biol., 111, 407-15.
4. Bertone A.L., Pittman D.D., Bouxsein M.L., Li J., Clancy B., Seeherman HJ. 2004. Adenoviral-mediated transfer of human BMP-6 gene accelerates healing in a rabbit ulnar osteotomy model. J Orthop Res., 22, 1261-70.
5. Besenfelder U., Aigner B., Müller M., Brem G. 1998. Generation and application of transgenic rabbits. In: Microinjection and transgenesis A. Cid-Arregui and A. García-Carrancám, eds. (Springer-Verlag, Berlin) pp. 561-586.
6. Bijvoet A.G., Van Hirtum H., Kroos M.A., Van de Kamp E.H., Schoneveld O., Visser P., Brakenhoff J.P., Weggeman M., van Corven E.J., Van der Ploeg A.T., Reuser A.J. 1999. Human acid alpha-glucosidase from rabbit milk has therapeutic effect in mice with glycogen storage disease type II. Hum Mol Genet., 8, 2145-53.
7. Boulanger L., Mallet S., Chensé P., Chrenek P., Viglietta C., Houdebine L.M., Renard J.P. 2002. Advantages and limits of using the ubiquitous expressed EF1alpha promoter for transgenesis in vivo and in vitro in rabbit. Transgenic Res., 11, 88.
8. Boullier A., Hennuyer N., Tailleux A., Furman C., Duverger N., Caillaud J.M., Castro G., Fievet C., Fruchart J.C., Duriez P. 2001. Increased levels of high-density lipoprotein cholesterol are ineffective in inhibiting the development of immune responses to oxidized low-density lipoprotein and atherosclerosis in transgenic rabbits expressing human apolipoprotein (apo) A-I with severe hypercholesterolaemia. Clin Sci (Lond)., 100, 343-55.
9. Bõsze Z., Hiripi L., Carnwath J.W., Niemann H. 2003. The transgenic rabbit as model for human diseases and as a source of biologically active recombinant proteins. Transgenic Res., 12, 541-53.
10. Brem G., Brenig B., Godman H.M., Selden R.C., Graf F., Kruff B., Springmann K., Hondele J., Meyer J., Winnacker E.-L., Krauszlich H. 1985. Production of transgenic mice, rabbits and pigs by microinjection into pronuclei. Zuchthygiene 20, 251-252.
11. Brem G., Hartl P., Besenfelder U., Wolf E., Zinovieva N., Pfaller R. 1994. Expression of synthetic cDNA sequences encoding human insulin-like growth factor-1 (IGF-1) in the mammary gland of transgenic rabbits. Gene., 149, 351-5.
12. Brem G., Besenfelder U., Zinovieva N., Seregi J., Solti L., Hartl P. 1995. Mammary gland-specific expression of chymosin constructs in transgenic rabbits. Theriogenology, 43, 175.
13. Brousseau M.E., Hoeg J.M. 1999. Transgenic rabbits as models for atherosclerosis research. J. Lipid Res., 40, 365-75.
14. Buelow R. (2006) Expression of a humanized antibody repertoire in transgenic rabbits. Conference V. Tahoe City USA. Transgenic Res., 15, 120.
15. Buhler T.A., Bruyere T., Went D.F., Stranzinger G, Burki K. 1990. Rabbit beta-casein promoter directs secretion of human interleukin-2 into the milk of transgenic rabbits. Biotechnology (N Y)., 8, 140-3.
16. Costa C., Solanes G., Visa J., Bosch F. 1998. Transgenic rabbits overexpressing growth hormone develop acromegaly and diabetes mellitus. FASEB J., 12, 1455-60.
17. Coulibaly S., Besenfelder U., Fleischmann M., Zinovieva N., Grossmann A., Wozny M., Bartke I., Togel M., Muller M., Brem G. 1999. Human nerve growth factor beta (hNGF-beta): mammary gland specific expression and production in transgenic rabbits. FEBS Lett. 444, 111-6.
18. Coulibaly S., Besenfelder U., Miller I., Zinovieva N., Lassnig C., Kotler T., Jameson J.L., Gemeiner M., Muller M., Brem G. 2002. Expression and characterization of functional recombinant bovine follicle-stimulating hormone (boFSHalpha/beta) produced in the milk of transgenic rabbits. Mol Reprod Dev., 63, 300-8.
19. Dorman S.E., Hatem C.L., Tyagi S., Aird K., Lopez-Molina J., Pitt M.L., Zook B.C., Dannenberg A.M. Jr, Bishai W.R., Manabe Y.C. 2004. Susceptibility to tuberculosis: clues from studies with inbred and outbred New Zealand White rabbits. Infect Immun., 72, 1700-5.
20. Dove A. 2000. Milking the genome for profit. Nature Biotechnol., 18, 1045-1048.
21. Dunn C.S., Mehtali M., Houdebine L.M., Gut J.P., Kirn A., Aubertin A.M., 1995. Human immunodeficiency virus type 1 infection of human CD4-transgenic rabbits. J Gen Virol., 76, 1327-36.
22. Duverger N., Emmanuel F., Viglietta C., Tailleux A., Benoît P., Atternot F., Cuine S., Fievet C., Fruchard J.C., Houdebine L.M., Denefle P. 1994. Transgenic rabbits expressing human apolipoprotein A-I in the liver. Thrombosis and Vasc. Biol., 90, 1-240.
23. Duverger N., Kruth H., Emmanuel F., Caillaud J.M., Viglietta C., Castro G., Tailleux A., Fievet C., Fruchart J.C., Houdebine L.M., Denefle P. 1996a Inhibition of atherosclerosis development in cholesterol-fed human apolipoprotein A-I-transgenic rabbits. Circulation. 94, 713-7.
24. Duverger N., Viglietta C., Berthou L., Emmanuel F., Tailleux A., Parmentier-Nihoul L., Laine B., Fievet C., Castro G., Fruchart J.C., Houbebine L.M., Denefie P. 1996b Transgenic rabbits expressing human apolipoprotein A-I in the liver. Arterioscler Thromb Vasc Biol., 16, 1424-9.
25. Edmunds T., Van Patten S.M., Pollock J, Hanson E., Bernasconi R., Higgins E., Manavalan P., Ziomek C., Meade H., McPherson J. M., and Cole E.S. 1998. Transgenically Produced Human Antithrombin: Structural and Functional Comparison to Human Plasma-Derived Antithrombin. Blood. 12, 4561-4571.
26. Fan J., Watanabe T. 2000a. Cholesterol-fed and transgenic rabbit models for the study of atherosclerosis. J Atheroscler Thromb., 7, 26-32.
27. Fan J., Watanabe T. 2000b Transgenic rabbits expressing human apolipoprotein (a). J Atheroscler Thromb., 7, 8-13.
28. Fan J., Watanabe T. 2003. Transgenic rabbits as therapeutic protein bioreactors and human disease models. Pharmacol Ther., 99, 261-82.
29. Fan J., Wang J., Bensadoun A., Lauer S.J., Dang Q., Mahley R.W., Taylor J.M. 1994. Overexpression of hepatic lipase in transgenic rabbits leads to a marked reduction of plasma high density lipoproteins and intermediate density lipoproteins. Proc Natl Acad Sci USA., 91, 8724-8.
30. Fan J., McCormick S.P., Krauss R.M., Taylor S., Quan R., Taylor J.M., Young S.G. 1995. Overexpression of human apolipoprotein B-100 in transgenic rabbits results in increased levels of LDL and decreased levels of HDL. Arterioscler Thromb Vasc Biol., 15, 1889-99.
31. Fan J., Ji Z.S., Huang Y., de Silva H., Sanan D., Mahley R.W., Innerarity T.L., Taylor J.M. 1998. Increased expression of apolipoprotein E in transgenic rabbits results in reduced levels of very low density lipoproteins and an accumulation of low density lipoproteins in plasma. J Clin Invest., 101, 2151-64.
32. Fan J., Challah M., Watanabe T. 1999. Transgenic rabbit models for biomedical research: current status, basic methods and future perspectives. Pathol Int., 49, 583-94.
33. Fan J., Challah M., Shimoyamada H., Watanabe T. 2000. Transgenic rabbits expressing human apolipoprotein(a) as a useful model for the study of lipoprotein(a). Ann N Y Acad Sci., 902, 347-51.
34. Fan J., Unoki H., Kojima N., Sun H., Shimoyamada H., Deng H., Okazaki M., Shikama H., Yamada N., Watanabe T. 2001. Overexpression of lipoprotein lipase in transgenic rabbits inhibits diet-induced hypercholesterolemia and atherosclerosis. J Biol Chem., 276, 40071-9.
35. Fan J., Wang X., Wu L., Matsumoto S.I., Liang J., Koike T., Ichikawa T., Sun H., Shikama H., Sasaguri Y., Watanabe T. 2004. Macrophage-specific overexpression of human matrix metalloproteinase-12 in transgenic rabbits. Transgenic Res., 13, 261-9.
36. Fernandes J., Tardif G., Martel-Pelletier J., Lascau-Coman V., Dupuis M., Moldovan F., Sheppard M., Krishnan B.R., Pelletier J.P. 1999. In vivo transfer of interleukin-1 receptor antagonist gene in osteoarthritic rabbit knee joints: prevention of osteoarthritis progression. Am J Pathol., 154, 1159-69.
37. Galet C., Le Bourhis C.M., Chopineau M., Le Griec G., Perrin A., Magallon T., Attal J., Viglietta C., Houdebine L.M. and Guillou F. 2001. Expression of a single beta-alpha chain protein of equine LH/CG in milk of transgenic rabbits and its biological activity. Mol. Cell. Endocrinol., 174, 31-40.
38. Ganda O.P., Simonson D.C. 1993. Growth hormone, acromegaly and diabetes. Diabetes Res., 1, 286-300.
39. Graur D., Duret L., Gouy M. 1996. Phylogenetic position of the order Lagomorpha (rabbits, hares and allies) Nature., 379, 333-335.
40. Groose- Hovest L., Muller S., Minoia R., Wolf E., Zakharchenko V., Wenigerkind H., Lassnig C., Besenfelder U., Muller M., Lytton S.D., Jung G., Brem G. 2004. Cloned transgenic farm animals produce a bispecific antibody for T cell-mediated tumor cell killing. Proc Natl Acad Sci U S A. 101, 6858-63.
41. Hammer R.E., Pursel V.G., Rexroad C.E. Jr, Wall R.J., Bolt D.J., Ebert K.M., Palmiter R.D., Brinster R.L. 1985. Production of transgenic rabbits, sheep and pigs by microinjection. Nature, 315, 680-3.
42. Hiripi L., Makovics F., Halter R., Baranyi M., Paul D., Carnwath J. W.. Bõsze Z., Niemann H. 2003. Expression of active human blood clotting factor VIII in mammary gland of transgenic rabbits. DNA Cell Biol., 22, 41-5.
43. Hoeg J.M., Vaisman B.L., Demosky S.J. Jr, Meyn S.M., Talley G.D., Hoyt R.F. Jr, Feldman S., Berard A.M., Sakai N., Wood D., Brousseau M.E., Marcovina S., Brewer H.B. Jr, Santamarina-Fojo S. 1996. Lecithin:cholesterol acyltransferase overexpression generates hyperalpha-lipoproteinemia and a nonatherogenic lipoprotein pattern in transgenic rabbits. J Biol Chem., 271, 4396-402.
44. Houdebine L.M. 1995.The production of pharmaceutical proteins from the milk of transgenic animals. Reprod Nutr Dev., 35, 609-17.
45. Houdebine L.M., 2002. Antibody manufacture in transgenic animals and comparisons with other systems. Current Opinion in Biotechnology, 13, 625-629.
46. Huang Y., Schwendner S.W., Rall S.C. Jr, Sanan D.A., Mahley R.W. 1997. Apolipoprotein E2 transgenic rabbits. Modulation of the type III hyperlipoproteinemic phenotype by estrogen and occurrence of spontaneous atherosclerosis. J Biol Chem., 272, 22685-94.
47. Ichikawa T., Liang J., Kitajima S., Koike T., Wang X., Sun H., Morimoto M., Shikama H., Watanabe T., Yamada N., Fan J. 2005. Macrophage-derived lipoprotein lipase increases aortic atherosclerosis in cholesterol-fed Tg rabbits. Atherosclerosis, 179, 87-95.
48. Ishida I., Tomizuka K., Yoshida H., Tahara T., Takahashi N., Ohguma A., Tanaka S., Umehashi M., Maeda H., Nozaki C., Halk E., Lonberg N. 2002. Production of human monoclonal and polyclonal antibodies in TransChromo animals. Cloning Stem Cells, 4, 91-102.
49. Jennes R. 1994. The composition of milk. In: Lactation: A comprehensive treatise (pp3-105) Academic Press, New York.
50. Knight K.L., Spieker-Polet H., Kazdin D.S., Oi V.T. 1988. Transgenic rabbits with lymphocytic leukemia induced by the c-myc oncogene fused with the immunoglobulin heavy chain enhancer. Proc Natl Acad Sci U S A., 85, 3130-4.
51. Koles K., van Berkel P.M., Mannesse M.L., Zoetemelk R.. Vliegenthart J.F., Kamerling J.P. 2004a. influence of lactation parameters on the N-glycosylation of recombinant human C1 inhibitor isolated from the milk of transgenic rabbits. Glycobiology, 14, 979-86.
52. Koles K., van Berkel P.H., Pieper F.R., Nuijens J.H., Mannesse M.L., Vliegenthart J.F., Kamerling J.P. 2004b. N- and O-glycans of recombinant human C1 inhibitor expressed in the milk of transgenic rabbits. Glycobiology, 14, 51-64.
53. Korhonen V.P., Tolvanen M., Hyttinen J.M., Uusi-Oukari M., Sinervirta R., Alhonen L., Jauhiainen M., Janne O.A., Janne J. 1997. Expression of bovine beta-lactoglobulin/human erythropoietin fusion protein in the milk of transgenic mice and rabbits. Eur J Biochem., 245, 482-9.
54. Kuroiwa Y., Kasinathan P., Choi Y.J., Naeem R., Tomizuka K., Sullivan E.J., Knott J.G., Duteau A., Goldsby R.A., Osborne B.A., Ishida I., Robl J.M. 2002. Cloned transchromosomic calves producing human immunoglobulin. Nat Biotechnol., 20, 889-94.
55. La Ville A., Turner P.R., Pittilo R.M., Martini S., Marenah C.B., Rowles P.M., Morris G., Thomson G.A., Woolf N., Lewis B. 1987. Hereditary hyperlipidemia in the rabbit due to overproduction of lipoproteins. I. Biochemical studies. Arteriosclerosis, 7, 105-12.
56. Lebuffe G., Boullier A., Tailleux A., Delfly B., Dupuis B., Fruchart J.C., Duverger N., Emmanuel F., Denefle P., Vallet B., Duriez P. 1997. Endothelial derived vasorelaxation is impaired in human APO A-I transgenic rabbits. Biochem Biophys Res Commun., 241, 205-11.
57. Leno M., Hague B.F., Teller R., Kindt T.J. 1995. HIV-1 mediates rapid apoptosis of lymphocytes from human CD4 transgenic but not normal rabbits. Virology, 213, 450-4.
58. Limonta J.M., Castro F.O., Martinez R., Puentes P., Ramos B., Aguilar A., Lleonart R.L., de la Fuente J. 1995. Transgenic rabbits as bioreactors for the production of human growth hormone. J Biotechnol., 40, 49-58.
59. Mackness M., Boullier A., Hennuyer N., Mackness B., Hall M., Tailleux A., Duriez P., Delfly B., Durrington P., Fruchart J.C., Duverger N., Caillaud J.M., Castro G. 2000. Paraoxonase activity is reduced by a pro-atherosclerotic diet in rabbits. Biochem Biophys Res Commun., 269, 232-6.
60. Manabe Y.C., Dannenberg A.M. Jr, Tyagi S.K., Hatem C.L., Yoder M., Woolwine S.C., Zook B.C., Pitt M.L., Bishai W.R. 2003. Different strains of Mycobacterium tuberculosis cause various spectrums of disease in the rabbit model of tuberculosis. Infect Immun., 71, 6004-11.
61. Marian A.J., Wu Y., Lim D.S., McCluggage M., Youker K., Yu Q.T., Brugada R., DeMayo F., Quinones M., Roberts R. 1999. A transgenic rabbit model for human hypertrophic cardiomyopathy. J Clin Invest., 104, 1683-92.
62. Massoud M., Attal J., Thepot D., Pointu H., Stinnakre M.G., Theron M.C., Lopez C., Houdebine L.M. 1996. The deleterious effects of human erythropoietin gene driven by the rabbit whey acidic protein gene promoter in transgenic rabbits. Reprod Nutr Dev., 36, 555-63.
63. McKee C., Gibson A., Dalrymple M., Emslie L., Garner I., Cottingham I. 1998. Production of biologically active salmon calcitonin in the milk of transgenic rabbits. Nat Biotechnol., 16, 647-51.
64. Palmiter R.D., Brinster R.L., Hammer R.E., Trumbauer M.E., Rosenfeld M.G., Birnberg N.C., Evans R.M. 1982. Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes. Nature, 300, 611-5.
65. Patel R., Nagueh S.F., Tsybouleva N., Abdellatif M., Lutucuta S., Kopelen H.A., Quinones M.A., Zoghbi W.A., Entman M.L., Roberts R., Marian A.J. 2001. Simvastatin induces regression of cardiac hypertrophy and fibrosis and improves cardiac function in a transgenic rabbit model of human hypertrophic cardiomyopathy. Circulation, 104, 317-24.
66. Peng X., Olson R.O., Christian C.B., Lang C.M., Kreider J.W. 1993. Papillomas and carcinomas in transgenic rabbits carrying EJ-ras DNA and cottontail rabbit papillomavirus DNA. J Virol., 67, 1698-701.
67. Peng X., Lang C.M., Kreider J.W. 1995. Methylation of cottontail rabbit papillomavirus DNA and tissue-specific expression in transgenic rabbits. Virus Res., 35, 101-8.
68. Peng X., Griffith J.W., Han R., Lang C.M., Kreider J.W. 1999. Development of keratoacanthomas and squamous cell carcinomas in transgenic rabbits with targeted expression of EJras oncogene in epidermis. Am J Pathol, 155, 315-24.
69. Peng X., Griffith J.W., Lang C.M. 2001. Reinitiated expression of EJras transgene in targeted epidermal cells of transgenic rabbits by cottontail rabbit papillomavirus infection. Cancer Lett., 171, 193-200.
70. Pinkert C.A., Galbreath E.J., Yang C.W., Striker L.J. 1994. Liver, renal and subcutaneous histopathology in PEPCK-bGH transgenic pigs. Transgenic Res., 3, 401-5.
71. Raju T.S., Briggs J.B., Borge S.M., Jones A.J. 2000. Species-specific variation in glycosylation of IgG: evidence for the species-specific sialylation and branch-specific galactosylation and importance for engineering recombinant glycoprotein therapeutics. Glycobiology, 10, 477-86.
72. Recalde D., Baroukh N., Viglietta C., Prince S., Verona J., Vergnes L., Pidoux J., Nanjee M. N., Brites F., Ochoa A., Castro G., Zakin M.M., Miller N.B., Houdebine L.M. 2004. Human apo A-I/C-III/A-IV gene cluster transgenic rabbits: plasma lipoproteins, lipid-transfer proteins, LCAT and effects of a high-cholesterol diet. FEBS Letters, 572, 294-298.
73. Rodriguez A., Castro P.O., Aguilar A., Ramos B., Del Barco D.G., Lleonart R., De la Fuente J. 1995. Expression of active human erythropoietin in the mammary gland of lactating transgenic mice and rabbits. Biol Res., 28, 141-53.
74. Rogart J.N., Barrach H.J., Chichester C.O. 1999. Articular collagen degradation in the Hulth-Telhag model of osteoarthritis. Osteoarthritis Cartilage., 7, 539-47.
75. Rouy D., Duverger N., Lin S.D., Emmanuel F., Houdebine L.M., Denefle P., Viglietta C., Gong E., Rubin E.M., Hughes S.D. 1998. Apolipoprotein(a) yeast artificial chromosome transgenic rabbits. Lipoprotein(a) assembly with human and rabbit apolipoprotein B. J Biol Chem., 273, 1247-51.
76. Sanbe A., James J., Tuzcu V., Nas S., Martin L., Gulick J., Osinska H., Sakthivel S., Klevitsky R., Ginsburg K.S., Bers D.M., Zinman B., Lakatta E.G., Robbins J. 2005. Transgenic rabbit model for human troponin I-based hypertrophic cardiomyopathy. Circulation, 111, 2330-8.
77. Senthil V., Chen S.N., Tsybouleva N., Halder T., Nagueh S.F., Willerson J.T., Roberts R., Marian A.J. 2005. Prevention of cardiac hypertrophy by atorvastatin in a transgenic rabbit model of human hypertrophic cardiomyopathy. Circ Res., 97, 285-92.
78. Sethupathi P., Spieker-Polet H., Polet H., Yam P.C., Tunyaplin C., Knight K.L. 1994. Lymphoid and non-lymphoid tumors in E kappa-myc transgenic rabbits. Leukemia, 8, 2144-55.
79. Shen J., Kuhn H., Petho-Schramm A., Chan L. 1995. Transgenic rabbits with the integrated human 15-lipoxygenase gene driven by a lysozyme promoter: macrophage-specific expression and variable positional specificity of the transgenic enzyme. FASEB J., 9, 1623-31.
80. Snyder B.W., Vitale J., Milos P., Gosselin J., Gillespie F., Ebert K., Hague B.F., Kindt T.J., Wadsworth S., Leibowitz P. 1995. Developmental and tissue-specific expression of human CD4 in transgenic rabbits. Mol Reprod Dev., 40, 419-28.
81. Soler E., Le Saux A., Guinut F., Passet B., Cohen R., Merle C., Charpilienne A., Fourgeux C., Sorel V, Piriou A., Schwartz-Cornil I., Cohen J., and Houdebine L.M. 2005. Production of two vaccinating recombinant rotavirus proteins in the milk of transgenic rabbits. Transgenic Research, 14, 833-844.
82. Soler E., Le Saux A., Guinut F., Passet B., Cohen R., Merle C., Charpilienne A., Fourgeux C., Sorel V., Piriou A., Schwartz-Cornil L, Cohen J. and Houdebine L.M. 2006.nProduction of two vaccinating recombinant rotavirus proteins in the milk of transgenic rabbits. Transgenic Animal Research Conference V. Tahoe City USA. Transgenic Res. 15, 120.
83. Sparks L.D. 2004. Cholesterol, copper, and accumulation of thioflavine S-reactive Alzheimer's-like amyloid beta in rabbit brain. J. Mol. Neurosci. 24, 97-104.
84. Spieker-Polet H., Sethupathi P., Yam P.C., Knight K.L. 1995. Rabbit monoclonal antibodies: generating a fusion partner to produce rabbit-rabbit hybridomas. Proc Natl Acad Sci USA., 92, 9348-52.
85. Strömqvist M., Houdebine L.M., Andersson J.O., Edlund A., Johanson T., Viglietta C., Puissant C., Hannson L. 1996. Recombinant human extracellular superoxide dismutase produced in milk of transgenic rabbits. Transgenic Res., 6, 271-278.
86. Subramanian A., Paleyanda R.K., Lubon H., Williams B.L., Gwazdauskas F.C., Knight J.W., Drohan W.N., Velander W.H. 1996. Rate limitations in posttranslational processing by the mammary gland of transgenic animals. Ann N Y Acad Sci., 782, 87-96.
87. Taboit-Dameron F., Malassagne B., Viglietta C.. Puissant C., Leroux-Coyau M., Chereau C., Attal J., Weill B. and Houdebine L.M. 1999. Association of the 5′HS4 sequence of the chicken beta-globin locus control region with human EF1 alpha gene promoter induces ubiquitous and high expression of human CD55 and CD59 cDNAs in transgenic rabbits. Transgenic Res., 8, 223-235.
88. Tardiff J.C., Factor S.M., Tompkins B.D., Hewett T.E., Palmer B.M., Moore R.L., Schwartz S., Robbins J., Leinwand L.A. 1998. A truncated cardiac troponin T molecule in transgenic mice suggests multiple cellular mechanisms for familial hypertrophic cardiomyopathy. J Clin Invest., 101, 2800-11.
89. Van den Hout J.M., Reuser A.J., de Klerk J.B., Arts W.F., Smeitink J.A., Van der Ploeg A.T. 2001. Enzyme therapy for pompe disease with recombinant human alpha-glucosidase from rabbit milk. J Inherit Metab Dis., 24, 266-74.
90. Van den Hout J.M., Kamphoven J.H., Winkel L.P., Arts W.F., De Klerk J.B., Loonen M.C., Vulto A.G., Cromme-Dijkhuis A., Weisglas-Kuperus N., Hop W., Van Hirtum H., Van Diggelen O.P., Boer M., Kroos M.A., Van Doorn P.A., Van der Voort E., Sibbles B., Van Corven E.J., Brakenhoff J.P., Van Hove J., Smeitink J.A., de Jong G., Reuser A.J., Van der Ploeg A.T. 2004. Long-term intravenous treatment of Pompe disease with recombinant human alpha-glucosidase from milk. Pediatrics, 113, e448-57.
91. Van Haeringen W.A., Den Bieman M.G., Lankhorst A.E., van Lith H.A., van Zutphen L.F. 2002. Application of AFLP markers for QTL mapping in the rabbit. Genome, 45, 914-21.
92. Van Zutphen L.F., Fox R.R. 1977. Strain differences in response to dietary cholesterol by JAX rabbits: correlation with esterase patterns. Atherosclerosis, 28, 435-46.
93. Viglietta C., Massoud M., Houdebine L.M. 1997. The generation of transgenic rabbits, in Transgenic Animals ed. Houdebine L.M. Harwood Academic Publishers pp., 3/1-3/3.
94. Wang X., Liang J., Koike T., Sun H., Ichikawa T., Kitajima S., Morimoto M., Shikama H., Watanabe T., Sasaguri Y., Fan J. 2004. Overexpression of human matrix metalloproteinase-12 enhances the development of inflammatory arthritis in transgenic rabbits. Am J Pathol., 165, 1375-83.
95. Watanabe Y. 1980. Serial inbreeding of rabbits with hereditary hyperlipidemia (WHHL-rabbit). Atherosclerosis, 36, 261-268.
96. Weidle U.H., Lenz H., Brem G. 1991. Genes encoding a mouse monoclonal antibody are expressed in transgenic mice, rabbits and pigs. Gene., 98, 185-91.
97. Wolf E., Jehle P.M., Weber M.M., Sauerwein H., Daxenberger A., Breier B.H., Besenfelder U., Frenyo L., Brem G. 1997. Human insulin-like growth factor I (IGF-I) produced in the mammary glands of transgenic rabbits: yield, receptor binding, mitogenic activity, and effects on IGF-binding proteins. Endocrinology. 138, 307-13.
98. Yamamoto T., Bishop R.W., Brown M.S., Goldstein J.L., Russell D.W. 1986. Deletion in cysteine-rich region of LDL receptor impedes transport to cell surface in WHHL rabbit. Science. 232, 1230-1237.
99. Yamanaka S., Balestra M.E., Ferrell L.D., Fan J., Arnold K.S., Taylor S., Taylor J.M., Innerarity T.L. 1995. Apolipoprotein B mRNA-editing protein induces hepatocellular carcinoma and dysplasia in transgenic animals. Proc Natl Acad Sci U.S.A. 92, 8483-7.
100. Zinovieva N., Lassnig C., Schams D., Besenfelder U., Wolf E., Muller S., Frenyo L., Seregi J., Muller M., Brem G. 1998. Stable production of human insulin-like growth factor 1 (IGF-1) in the milk of hemi- and homozygous transgenic rabbits over several generations. Transgenic Res., 7, 437-47.