Transgenic rabbits expressing human apolipoprotein A-I in the liver

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 16, Issue 12, 1996, Pages 1424-1429

  Duverger, Nicolas ^a   Viglietta, Céline ^c   Berthou, Laurence ^a   Emmanuel, Florence ^a   Tailleux, Anne ^b   Parmentier Nihoul, Laurence ^b   Laine, Bernard ^b   Fievet, Catherine ^b   Castro, Graciela ^b   Fruchart, Jean Charles ^b   Houbebine, Louis Marie ^c   Denèfle, Patrice ^a  

^a SANOFI   (France)

^b INSTITUT PASTEUR DE LILLE   (France)

^c CEMAGREF   (France)

Author keywords

apolipoprotein A I; cholesterol; lipoprotein; New Zealand White rabbit; transgenic

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROGENESIS; CHOLESTEROL METABOLISM; CHOLESTEROL TRANSPORT; FEMALE; GENE EXPRESSION REGULATION; GENE TARGETING; HUMAN; LIPID COMPOSITION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RABBIT; TRANSGENIC ANIMAL;

EID: 8044254625     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.16.12.1424     Document Type: Article

References (50)

1. Gordon DJ, Knoke J, Probsfield JL, Superko R, Tyroler HA. High-density lipoprotein cholesterol and coronary heart disease in hypercholesterolemic men: the Lipid Research Clinics Coronary Primary Prevention Trial. Circulation. 1986;74:1217-1225.
2. Miller NE. Association of high-density lipoprotein subclasses and apolipoproteins with ischemic heart disease and coronary atherosclerosis. Am Heart J. 1987;113:589-597.
3. Badimon JJ, Badimon L, Fuster V. Regression of atherosclerotic lesions by high-density lipoprotein plasma fraction in the cholesterol-fed rabbit. J Clin Invest. 1990;85:1234-1241.
4. Rubin EM, Krauss RM, Spangier EA, Verstuyft JG, Gift SM. Inhibition of early atherogenesis in transgenic mice by human apolipoprotein A-I. Nature. 1991;353:265-267.
5. Chapman JM. Comparative analysis of mammalian plasma lipoproteins. Methods Enzymol. 1986;128:71-147.
6. Nagashima M, McLean JW, Lawn RL. Cloning and mRNA tissue distribution of rabbit cholesteryl ester transfer protein. J Lipid Res. 1988;29:1643-1649.
7. Buja LM, Kita T, Goldstein JL, Watanabe Y, Brown MS. Cellular pathology of progressive atherosclerosis in the WHHL rabbit: an animal model of familial hypercholesterolemia. Arteriosclerosis. 1983; 3:87-101.
8. La Ville A, Turner PR, Pittilo M, Martini S, Marenah CB, Rowles PM, Morris G, Thomson GA, Woolf N, Lewis B. Hereditary hyperlipidemia in the rabbit due to overproduction of lipoproteins. Arteriosclerosis. 1987;7:105-112.
9. Bocan TMA, Bak Mueller S, Uhlendorf PD, Newton RS, Krause BR. Comparison of CI-976, an ACAT inhibitor, and selected lipid-lowering agents for antiatherosclerotic activity in iliac-femoral and thoracic aortic lesions: a biochemical, morphological, and morphometric evaluation. Arterioscler Thromb. 1991;11:1830-1843.
10. Tsukada T, Rosenfeld M, Ross R, Gow AM. Immunocytochemical analysis of cellular components in atherosclerotic lesions: use of monoclonal antibodies with the Watanabe and fat fed rabbit. Arteriosclerosis. 1986;6:601-613.
11. Adams CMV, Miller NE, Morgan RS, Rao SN. Lipoprotein levels and tissue lipid in fatty-fibrous atherosclerosis induced in rabbits by two years' cholesterol feeding at a low level. Atherosclerosis. 1982; 44:1-8.
12. Lupu F, Danaricu I, Simionescu N. Development of intracellular lipid deposits in the lipid-laden cells of atherosclerotic lesions: a cytochemical and ultrastructural study. Atherosclerosis. 1987;67: 127-142.
13. Hunt CE, Duncan LA. Hyperlipoproteinemia and atherosclerosis in rabbits fed low-level cholesterol and lecithin. Br J Exp Pathol. 1985; 66:35-46.
14. Davies MJ. Studies of the St. Thomas rabbit. In: A Critical Analysis of Animal Models of Atherosclerosis and Restenosis. Bristol-Myers Squibb Symposium on Cardiovascular Research. Seattle, Wash: 1993;10:1.
15. Massoud M, Bischoff R, Dalemans W, Pointu H, Attal J, Schultz H, Clesse D, Stinnakre MG, Pavinari A, Houdebine LM. Expression of active recombinant human alpha 1-antitrypsin in transgenic rabbits. J Biotechnol. 1991;18:193-204.
16. Knight KL, Spieker-Polet H, Kazdin DS. Transgenic rabbits with lymphocytic leukemia induced by the c-myc oncogene fused with immunoglobulin heavy chain enhancer. Proc Natl Acad Sci U S A. 1988;85:3130-3134.
17. Rubin EM, Ishida BY, Clift SM, Krauss RM. Expression of human apolipoprotein A-I in transgenic mice results in reduced plasma levels of murine apolipoprotein A-I and the appearance of two high density lipoprotein size subclasses. Proc Natl Acad Sci U S A. 1991;88: 434-438.
18. Chomczynski P, Sacchi N. Single step method for RNA isolation by acid guanidinium-thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162:156-159.
19. Breslow JL, Ross D, McPherson J, Williams H, Nussbaum AL, Karathanasis SK, Zannis VI. Isolation and characterization of cDNA clones for human apolipoprotein A-I. Proc Natl Acad Sci U S A. 1982;79:6861-6865.
20. Pruvost I, Fievet C, Durieux C, Vu Dac N, Fruchart JC. Electro and immunonephelometric assays of apolipoprotein A-I by using a mixture of monoclonal antibodies. Clin Chem. 1988;34:2048-2052.
21. Fievet C, Durieux C, Milne R, Delaunay T, Agnani G, Bazin H, Marcel Y, Fruchart JC. Rat monoclonal antibodies to human apolipoprotein B: advantages and applications. J Lipid Res. 1991;30: 1015-1024.
22. Brousseau T, Clavey V, Bard JM, Fruchart JC. Sequential ultracentrifugation micromethod for separation of serum lipoproteins and assays of lipids, apolipoproteins, and lipoprotein particles. Clin Chem. 1993;39:960-964.
23. Nichols AV, Krauss RM, Musliner TA. Nondenaturing polyacrylamide gradient gel electrophoresis. Methods Enzymol. 1986;128: 417-431.
24. Laemmli UK. Cleavage of structural protein during the assembly of the head of bacteriophage T4. Nature. 1970;227:680-685.
25. Castro GR, Fielding CJ. Early incorporation of cell derived cholesterol into pre-β-migrating high-density-lipoprotein. Biochemistry. 1988;25:25-29.
26. de la Llera Moya M, Atger V, Paul JL, Fournier N, Moatti N, Giral P, Friday KE, Rothblat G. A cell culture system for screening human serum for ability to promote cellular cholesterol efflux. Arterioscler Thromb. 1994;14:1056-1065.
27. Duverger N, Rader D, Duchateau P, Fruchart JC, Castro G, Brewer HB Jr. Biochemical characterization of the three major subclasses of lipoprotein A-I preparatively isolated from human plasma. Biochemistry. 1993;23:12372-12379.
28. 3. J Biol Chem. 1989;264:6488-6494.
29. Chao Y, Yamin T, Thompson GM, Kroon PA. Tissue-specific expression of genes encoding apolipoprotein E and apolipoprotein A-I in rabbits. J Biol Chem. 1984;259:5306-5309.
30. Pan T, Hao Q, Yamin T, Dai P, Chen B, Chen S, Kroonand PA, Chao Y. Rabbit apolipoprotein A-I mRNA and gene: evidence that rabbit apolipoprotein A-I is synthetized in the intestine but not in the liver. Eur J Biochem. 1987;170:99-104.
31. Reisher SR, Fisher EA, Feinstein SI. Rabbit and rat liver nuclei both contain proteins which bind to the regions controlling apolipoprotein A-I gene expression. Eur J Biochem. 1993;216:247-253.
32. Rea TJ, Bisgaier CL, DeMattos RB, Pape ME. Rabbit liver apolipoprotein A-I synthesis is under nonparenchymal cell paracrine control. J Lipid Res. 1994;35:1274-1282.
33. Walsh A, Azrolan N, Wang K, Marcigliano A, O'Connell A, Breslow JL. Intestinal expression of the human apoA-I gene in transgenic mice is controlled by a DNA region 3′ to the gene in the promoter of the adjacent convergently transcribed apoC-III gene. J Lipid Res. 1993; 34:617-623.
34. Widom RL, Ladias JAA, Kouidou S, Karathanasis SK. Synergistic interactions between transcription factors control expression of the apolipoprotein AI gene in liver cells. Mol Cell Biol. 1991;11: 677-687.
35. Børresen AL, Kindt TJ. Purification and partial characterization of the apo A-I of rabbit high density lipoprotein. J Immunogenet. 1978;5:5-12.
36. Patsch JR, Gotto AM, Olivecrona T, Eisenberg S. Formation of HDL2-like particles during lipolysis of VLDL in vitro. Proc Natl Acad Sci U S A. 1978;75:4519-4522.
37. Shirai K, Barnhart RL, Jackson RL. Hydrolysis of human plasma high density lipoprotein2-phospholipids and triglycerides by hepatic lipase. Biochem Biophys Res Commun. 1981;100:591-599.
38. Brinton EA, Eisenberg S, Breslow JL. Human HDL cholesterol levels are determined by apoA-I fractional catabolic rate, which correlates inversely with estimates of HDL size: effects of gender, hepatic and lipoprotein lipases, triglyceride and insulin levels, and body fat distribution. Arterioscler Thromb. 1994;14:707-720.
39. Clay MA, Hopkins GJ, Ehnholm CP, Barter PJ. The rabbit as an animal model of hepatic lipase deficiency. Biochim Biophys Acta. 1989;1002:173-181.
40. Newnham HH, Hopkins GJ, Devlin S, Barter PJ. Lipoprotein lipase prevents the hepatic lipase-induced reduction in particle size of high density lipoproteins during incubation of human plasma. Atherosclerosis. 1990;82:167-176.
41. Fan J, Wang J, Bensadoun A, Lauer SJ, Dang Q, Mahley RW, Taylor JM. Overexpression of hepatic lipase in transgenic rabbits leads to a marked reduction of plasma high density lipoproteins and intermediate density lipoproteins. Proc Natl Acad Sci U S A. 1994;91: 8724-8728.
42. Kunitake ST, La Sala KJ, Kane JP. Apolipoprotein A-I-containing lipoproteins with pre-beta electrophoretic mobility. J Lipid Res. 1985;26:549-555.
43. Ishida BY, Frolich J, Fielding CJ. Pre-beta-migrating high density lipoprotein: quantitation in normal and hyperlipidemic plasma by solid phase radioimmunoassay following electrophoretic transfer. J Lipid Res. 1987;28:778-786.
44. Neary RH, Gowland E. Stability of free apolipoprotein A-I concentration in serum, and its measurement in normal and hyperlipemic subjects. Clin Chem. 1987;33:1163-1169.
45. O'Kane MJ, Wisdom GB, McEneny J, McFerran NV, Trimble ER. Pre-beta high density lipoprotein determined by immunoblotting with chemiluminescent detection. Clin Chem. 1992;38:2273-2277.
46. Ishida BY, Albee D, Paigen B. Interconversion of pre-beta migrating lipoproteins containing apolipoprotein A-I and HDL. J Lipid Res. 1990;31:227-236.
47. Castle CJ, Pape ME, Marotti KR, Melchior GW. Secretion of prebeta-migrating apoA-I by cynomolgus monkey hepatocytes in culture. J Lipid Res. 1991;32:439-447.
48. Lefevre M, Sloop CH, Roheim PS. Characterization of dog prenodal peripheral lymph lipoproteins: evidence for the peripheral formation of lipoprotein-unassociated apoA-I with slow preβ-electrophoretic mobility. J Lipid Res. 1988;29:1139-1148.
49. Fielding CJ, Fielding PE. Molecular physiology of reverse cholesterol transport. J Lipid Res. 1995;36:211-228.
50. Crespo P, Ordovas JM, Albajar M, Rodriguez JC, Ortiz JM, Leon J. Hypercholesterolemia induces differential expression of rabbit apolipoprotein A and C genes. Atherosclerosis. 1992;95:95-103.