Pharmacology of the lower urinary tract and management of overactive bladder

Journal of the Turkish German Gynecology Association

Volumn 7, Issue 2, 2006, Pages 146-157

  Canda, Abdullah Erdem ^a,c   Cross, Rebecca L ^b   Chapple, Christopher R ^a  

^a ROYAL HALLAMSHIRE HOSPITAL   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

^c NONE   (Turkey)

Author keywords

Detrusor; Lower urinary tract; Overactive bladder; Receptors; Transmitters

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPHA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; DARIFENACIN; HISTAMINE; LEUKOTRIENE; LEUKOTRIENE RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; NEUROPEPTIDE; NEUROPEPTIDE RECEPTOR; NITRIC OXIDE; OXYBUTYNIN; PROSTANOID; PROSTANOID RECEPTOR; SEROTONIN; SOLIFENACIN; TOLTERODINE; VANILLOID RECEPTOR;

ADRENERGIC SYSTEM; BLADDER CONTRACTION; BLADDER FUNCTION; CHOLINERGIC SYSTEM; DETRUSOR MUSCLE; DRUG ACTIVITY; EXCITABILITY; GALLBLADDER EMPTYING; HUMAN; MICTURITION; MUSCLE RELAXATION; NONADRENERGIC NONCHOLINERGIC NERVE; OVERACTIVE BLADDER; PARASYMPATHETIC NERVE; PROTEIN BINDING; PROTEIN FUNCTION; REVIEW; SENSORY NERVE; SIGNAL TRANSDUCTION; SMOOTH MUSCLE; SYMPATHETIC NERVE; URETHRA; URINARY TRACT FUNCTION; UROTHELIUM;

EID: 33746275235     PISSN: 13090399     EISSN: 13090380     Source Type: Journal    
DOI: None     Document Type: Review

References (143)

1. Andersson KE and Arner A. Urinary Bladder Contraction and Relaxation: Physiology and Pathophysiology. Physiol Rev 2004;84(3):935-86.
2. Chess-Williams R. Muscarinic receptors of the urinary bladder: detrusor, urothelial and prejunctional. Auton Autacoid Pharmacol 2002;22(3):133-45.
3. Nagahama K, Tsujii T, Morita T et al. Differences between proximal and distal portions of the male rabbit posterior urethra in the physiological role of muscarinic cholinergic receptors. Br J Pharmacol 1998;124:1175-80.
4. Burnstock G. Purinergic signalling in lower urinary tract. In: Purinergic and Pyrimidinergic Signalling I: Molecular, Nervous and Urogenitary System Function. Ch. 15 (Eds M.P. Abbracchio & M. Williams), pp. 421-515, 2001. Springer-Verlag, Berlin Heidelberg.
5. Chancellor MB, Kaplan SA, Blaivas JG. The cholinergic and purinergic components of detrusor contractility in a whole rabbit bladder model. J Urol 1992;148:906-9.
6. Theobald RJ. Purinergic and cholinergic components of bladder contactility and now. Life Sci 1995;56:445-54.
7. Abrams P, Cardozo L, Fall M et al. The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. Neurourol Urodyn 2002;21:167-78.
8. Milsom I, Abrams P, Cardozo L et al. How widespread are the symptoms of an overactive bladder and how are they managed? A population-based prevalence study. BJU Int 2001;87:760-6.
9. Chapple CR, Yamanishi T, Chess-Williams R. Muscarinic receptor subtypes and management of the overactive bladder. Urology 2002;60 (5 Suppl 1):82-9.
10. Wang P, Luthin GR, Ruggieri MR. Muscarinic acetylcholine receptor subtypes mediating urinary bladder contractility and coupling to GTP binding proteins. J Pharmacol Exp Ther 1995;273:959-66.
11. Yamanishi T, Chapple CR, Yasuda K, Chess-Williams R. The role of M(2)-muscarinic receptors in mediating contraction of the pig urinary bladder in vitro. Br J Pharmacol 2000;131(7):1482-8.
12. Chess-Williams R, Chapple CR, Yamanishi T et al. The minor population of M3-receptors mediate contraction of human detrusor muscle in vitro. J Auton Pharmacol 2001;21(5-6):243-8.
13. D'Agostino G, Bolognesi ML, Lucchelli A et al. Prejunctional muscarinic inhibitory control of acetylcholine release in the human isolated detrusor: involvement of the M4 receptor subtype. Br J Pharmacol 2000;129:493-500.
14. Levin RM, Ruggieri MR, Wein AJ. Identification of receptor subtypes in the rabbit and human urinary bladder by selective radio-ligand binding. J Urol 1998;139:844-8.
15. Mimata H, Wheeler MA, Fukumoto Y et al. Enhancement of muscarinic receptor-coupled phosphatidylinositol hydrolysis in diabetic bladder. Mol Cell Biochem 1995;152:71-6.
16. Caulfield MP, Birdsall NJM. International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors. Pharmacol Rev 1998;50:279-90.
17. Andersson KE, Holmquist F, Fovaeus M et al. Muscarinic receptor stimulation of phosphoinositide hydrolysis in the human isolated urinary bladder. J Urol 1991;146:1156-9.
18. 2+ signalling in cultured smooth muscle cells from human bladder. Exp Physiol 1996;81:553-64.
19. Visser AJ, Van Mastrigt R. The role of intracellular and extracellular calcium in mechanical and intracellular electrical activity of human urinary bladder smooth muscle. Urol Res 2000;28:260-8.
20. Jezior JR, Brady JD, Rosentein DI et al. Dependency of detrusor contraction on calcium sensitisation and calcium entry through LOE-908-sensitive channels. Br J Pharmacol 2001;134:78-87.
21. Harriss DR, Marsh KA, Birmingham AT, Hill SJ. Expression of muscarinic M3-receptors coupled to inositol phospholipid hydrolysis in human detrusor cultured smooth muscle cells. J Urol 1995;154:1241-5.
22. Eglen RM, Hegde SS, Watson N. Muscarinic receptor subtypes and smooth muscle function. Pharmacol Rev 1996;15:114-9.
23. Yamanishi T, Yasuda K, Chapple CR, Chess-Williams R. The role of M2-muscarinic receptors in mediating contraction of the pig urinary bladder in vitro. Br J Pharmacol 2000;131(7):1482-8.
24. Hypolite JA, Longhurst PA, Gong C et al. Metabolic studies on rabbit bladder smooth muscle and mucosal epithelium. Mol Cell Biochem 1993;125:35-42.
25. Hawthorn MH, Chapple CR, Cock M, Chess-Williams R. Urothelium-derived inhibitory factor(s) influences on detrusor muscle contractility in vitro. Br J Pharmacol 2000;129(3):416-9.
26. Wayabayashi Y, Kojima Y, Makiura Y et al. Acetylcholinesterase positive axons in the mucosa of urinary bladder of adult cats: retrograde tracing and degeneration studies. Histol Histopathol 1995;10:523-30.
27. Templeman L, Chapple CR, Chess-Williams R. Urothelium derived inhibitory factor and cross-talk among receptors in the trigone of the bladder of the pig. J Urol 2002;167(2 Pt 1):742-5.
28. Chaiyaprasithi B, Mang CF, Kilbinger H, Hohenfellner M. Inhibition of human detrusor contraction by a urothelium derived factor. J Urol 2003;170(5):1897-900.
29. Nomiya M, Yamaguchi O. A quantitative analysis of mRNA expression of α1 and β-adrenoceptor subtypes and their functional roles in human normal and obstructed bladders. J Urol 2003;170:649-53.
30. Andersson KE, Wein AJ. Pharmacology of the lower urinary tract: basis for current and future treatments of urinary incontinence. Pharmacol Rev 2004;56(4):581-631.
31. Morita T, Iizuka H, Iwata T and Kondo S. Function and distribution of β3-adrenoceptors in rat, rabbit and human urinary bladder and external urethral sphincter. J Smooth Muscle Res 2000;36:21-32.
32. Andersson KE. Pharmacology of lower urinary tract smooth muscles and penile erectile tissues. Pharmacol Rev 1993;45:253-308.
33. Restorick JM and Mundy AR. The density of cholinergic and alpha and beta adrenergic receptors in the normal and hyperreflexic human detrusor. Br J Urol 1989;63:32-5.
34. Malloy BJ, Price DT, Price RR et al. Alpha1-adrenergic receptor subtypes in human detrusor. J Urol 1998;160:937-43.
35. Smith DJ, Chapple CR. In vitro response of human bladder smooth muscle in unstable obstructed male bladders: a study of pathophysiological causes? Neurourol Urodyn 1994;34:14-5.
36. Sjogren C, Andersson KE, Husted S et al. Atropine resistance of transmurally stimulated isolated human bladder muscle. J Urol 1982;128:1368-71.
37. Klein LA. Urge incontinence can be a disease of bladder sensors. J Urol 1988;139:1010-4.
38. Andersson KE. Bladder Activation: Afferent Mechanisms. Urology 2002;59 (Suppl 5a):43-50.
39. Wakabayashi Y, Tomoyoshi T, Fujimiya M et al. Substance P-containing axon terminals in the mucosa of the human urinary bladder: pre-embedding immunohistochemistry using cryostat sections for electron microscopy. Histochemistry 1993;100:401-7.
40. Maggi CA. Tachykinins and calcitonin gene-related peptide (CGRP) as cotransmitters released from peripheral endings of sensory nerves. Prog Neurobiol 1995;45:1-98.
41. Kumar V, Chapple CR, Chess-Williams R. Characteristics of adenosine triphosphatase release from porcine and human normal bladder. J Urol 2004;172(2):744-7.
42. Burnstock G, Williams M. P2 purinergic receptors: modulation of cell function and therapeutic potential. J Pharmacol Exp Ther 2000;295:862-9.
43. Dixon JS, Gilpin CJ. Presumptive sensory axons of the human urinary bladder: a fine structural study. J Anat 1987;151:199-207.
44. O'Reilly BA, Kosaka AH, Chang TK et al. A quantitative analysis of purinoceptor expression in the bladders of patients with symptomatic outlet obstruction. BJU Int 2001;87:617-22.
45. Elneil S, Skepper JN, Kidd EJ et al. Distribution of P2X(1) and P2X(3) receptors in the rat and human urinary bladder. Pharmacology 2001;63(2):120-8.
46. Andersson KE, Hedund P. Pharmacologic perspective on the physiology of the lower urinary tract. Urology 2002;60(Suppl 5A):13-21.
47. Abbracchio MP, Boarder M, Burnstock G et al. Purinergic signaling in lower urinary tract. In: Purinergic and Pyrimidine Signaling I: Molecular, Nervous and Urogenitary System Function. Edited by M. P. Abbracchio and M. Williams. Berlin: Springer pp. 423-515, 2001.
48. Harvey RA, Skennerton DE, Newgreen D, Fry CH. The contractile potency of adenosine triphosphate and ecto-adenosine triphosphatase activity in guinea pig detrusor and detrusor from patients with a stable, unstable or obstructed bladder. J Urol 2002;168:1235-9.
49. O'Reilly BA, Kosaka AH, Knight GF et al. P2X receptors and their role in female idiopathic detrusor instability. J Urol 2002;167:157-64.
50. Moore KH, Ray FR and Barden JA. Loss of purinergic P2X(3) and P2X(5) receptor innervation in human detrusor from adults with urge incontinence. J Neurosci 2001;21(18):RC166.
51. Andersson KE, Persson K. The L-arginine/nitric oxide pathway and nonadrenergic, non-cholinergic relaxation of the lower urinary tract. Gen Pharmacol 1993;24:833-9.
52. Ehren I, Iversen H, Jansson O et al. Localization of nitric oxide synthase activity in the human lower urinary tract and its correlation with neuroeffector responses. Urology 1994;44:683-7.
53. Masuda H, Tsujii T, Okuno T et al. Localization and role of nitric oxide synthase and endogenous nitric oxide synthase inhibitors in the rabbit lower urinary tract. J Urol 2002;167:2235-40.
54. Lemack GE, Zimmern PE, Vazquez D et al. Altered response to partial bladder outlet obstruction in mice lacking inducible nitric oxide synthase. J Urol 2000;163:1981-7.
55. James MJ, Birmingham AT, Hill SJ. Partial mediation by nitric oxide of the relaxation of human isolated detrusor strips in response to electrical field stimulation. Br J Clin Pharmacol 1993;35:366-72.
56. Hofmann F, Ammendola A, Schlossmann J. Rising behind NO: cGMP-dependent protein kinases. J Cell Sci 2000;113:1671-6.
57. Klarskov P. Non-cholinergic, non-adrenergic inhibitory nerve responses of bladder outlet smooth muscle in vitro. Br J Urol 1987;60:337-42.
58. Coolsaet BL. Bladder compliance and detrusor activity during the collection phase. Neurourol Urodyn 1985;4:263-73.
59. Klevmark B. Motility of the urinary bladder in cats during filling at physiological rates. II. Effects of extrinsic bladder denervation on intramural tension and on intravesical pressure patterns. Acta Physiol Scand 1977;101:176-84.
60. De Groat WC. Nervous control of the urinary bladder of the cat. Brain Res 1975;87:201-11.
61. Theobald RJ Jr. The effect of NG-monomethyl-L-arginine on bladder function. Eur J Pharmacol 1996;311:73-8.
62. Klarskov P, Hørby-Petersen J. Infuence of serotonin on lower urinary tract smooth muscle in vitro. Br J Urol 1986;58:507-13.
63. Tonini M, Messori E, Franceschetti GP et al. Characterization of the 5-HT receptor potentiating neuromuscular cholinergic transmission in strips of human isolated detrusor muscle. Br J Pharmacol 1994;113:1-2.
64. Szallasi A, Blumberg PM. Vanilloid (capsaicin) receptors and mechanisms. Pharmacol Rev 1999;51:159-211.
65. Hayes P, Meadows J, Gunthorpe MJ et al. Cloning and functional expression of a human orthologue of rat vanilloid receptor-1. Pain 2000;88 (2):205-15.
66. Yiangou Y, Facer P, Ford A et al. Capsaicin receptor VR1 and ATP-gated ion channel P2X3 in human urinary bladder. BJU Int 2001;87(9):774-9.
67. Birder LA, Kanai AJ, de Groat WC et al. Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells. Proc Natl Acad Sci U S A 2001;98:13396-401.
68. Cruz F. Mechanisms involved in new therapies for overactive bladder. Urology 2004:63 (Suppl 3a):65-73.
69. Caterina MJ, Schumacher MA, Tominaga M et al. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 1997;389:816-24.
70. Caterina MJ, Leffler A, Malmberg AB et al. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 2000;288:306-13.
71. Tominaga M, Caterina MJ, Malmberg AB et al. The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron 1998;21(3):531-43.
72. De Ridder D, Chandiramani V, Dasgupta P et al. Intravesical capsaicin as a treatment for refractory detrusor hyperreflexia: a dual center study with long-term followup. J Urol 1997;158(6):2087-92.
73. Giannantoni A, Di Stasi SM, Stephen RL et al. Intravesical capsaicin versus resiniferatoxin in patients with detrusor hyperreflexia: a prospective randomized study. J Urol 2002;167(4):1710-4.
74. Avelino A, Cruz C, Cruz F. Nerve growth factor regulates galanin and c-jun overexpression occurring in dorsal root ganglion cells after intravesical resiniferatoxin application. Brain Res 2002;951:264-9.
75. Szoke E, Seress L, Szolcsanyi J. Neonatal capsaicin treatment results in prolonged mitochondrial damage and delayed cell death of B cells in the rat trigeminal ganglia. Neuroscience 2002;113:925-37.
76. Habler HJ, Jänig W, Koltzenburg M. Activation of unmyelinated afferent fibers by mechanical stimuli and inflammation of the urinary bladder in the cat. J Physiol (Lond) 1990;425:545-62.
77. de Groat WC: A neurologic basis for the overactive bladder. Urology 1997;50 (suppl 6A):36-52.
78. Jankovic J, Brin MF. Botulinum toxin: historical perspective and potential new indications. Muscle Nerve 1997;6(suppl):129-45.
79. Schurch B, Stöhrer M, Kramer G et al. Botulinum-A toxin for treating detrusor hyperreflexia in spinal cord injured patients: a new alternative to anticholinergic drugs? Preliminary results. J Urol 2000;164:692-7.
80. Khan MA, Thompson CS, Mumtaz FH et al. Role of prostaglandins in the urinary bladder: an update. Prostaglandins Leukot Essent Fatty Acids 1998;59:415-22.
81. Gilmore NJ, Vane JR. Hormones released into the circulation when the urinary bladder of the anaesthetized dog is distended. Clin Sci 1971;41:69-83.
82. Andersson KE, Sjogren C. Aspects on the physiology and pharmacology of the bladder and urethra. Prog Neurobiol 1982;19:71-89.
83. 2+ elevation and contraction of the human detrusor muscle. J Urol 2003;170:638-44.
84. Sjogren C, Andersson KE, Mattiasson A. Effects of vasoactive intestinal polypeptide on isolated urethral and urinary bladder smooth muscle from rabbit and man. J Urol 1985;133:136-40.
85. Uckert S, Stief CG, Lietz B et al. Possible role of bioactive peptides in the regulation of human detrusor smooth muscle. World J Urol 2002;20:244-9.
86. Chapple CR, Milner P, Moss HE, Burnstock G. Loss of sensory neuropeptides in the obstructed human bladder. Br J Urol 1992;70:373-81.
87. Gu J, Restorick JM, Blank MA et al. Vasoactive intestinal polypeptide in the normal and unstable bladder. Br J Urol 1983;55:645-7.
88. Garcia-Pascual A, Persson K, Holmquist F, and Andersson KE. Endothelin-1-induced phosphoinositide hydrolysis and contraction in isolated rabbit detrusor and urethral smooth muscle. Gen Pharmacol 1993;24:131-8.
89. Lecci A, Maggi CA. Tachykinins as modulators of the micturition reflex in the central and peripheral nervous system. Regul Pept 2001;101:1-18.
90. Maggi CA, Patacchini R, Santicioli P et al. Further studies on the motor response of the human isolated urinary bladder to tachykinins, capsaicin and electrical field stimulation. Gen Pharmacol 1989;20:663-9.
91. Waldeck K, Lindberg BF, Persson K, Andersson KE. Characterization of angiotensin II formation in human isolated bladder by selective inhibitors of ACE and human chymase: a functional and biochemical study. Br J Pharmacol 1997;121:1081-6.
92. Lam DS, Dias LS, Moore KH, Burcher E. Angiotensin II in child urinary bladder: functional and autoradiographic studies. BJU Int 2000;86:494-501.
93. Drake MJ, Headlund P, Harvey IJ et al. Partial outlet obstruction enhances modular autonomous activity in the isolated rat bladder. Journal of Urology 2003;170:276-9.
94. Fry CH, Sui GP, Severs NJ, Wu C. Spontaneous activity and electrical coupling in human detrusor smooth muscle: implications for detrusor overactivity? Urology 2004;63 (3 Suppl 1):3-10.
95. Montgomery BS, Fry CH. The action potential and net membrane currents in isolated human detrusor smooth muscle cells. J Urol 1992;147(1):176-84.
96. Hashitani H, Brading AF, Suzuki H. Correlation between spontaneous electrical, calcium and mechanical activity in detrusor smooth muscle of the guinea-pig bladder. Br J Pharmacol 2004;141(1):183-93.
97. Sanders KM. A case for interstitial cells of Cajal as pacemakers and mediators of neurotransmission in the gastrointestinal tract. Gastroenterology 1996;111(2):492-515.
98. Hirst GD, Ward SM. Interstitial cells: involvement in rhythmicity and neural control of gut smooth muscle. J Physiol 2003;550(Pt 2):337-46.
99. Smet PJ, Jonavicius J, Marshall VR, de Vente J. Distribution of nitric oxide synthase-immunoreactive nerves and identification of the cellular targets of nitric oxide in guinea-pig and human urinary bladder by cGMP immunohistochemistry. Neuroscience 1996;71(2):337-48.
100. McCloskey KD, Gurney AM. Kit positive cells in the guinea pig bladder. J Urol 2002;168(2):832-6.
101. Sergeant GP, Hollywood MA, McCloskey KD et al. Specialised pacemaking cells in the rabbit urethra. J Physiol 2000;526 Pt 2:359-66.
102. Gillespie JI, Markerink-van Ittersum M, de Vente J. cGMP-generating cells in the bladder wall: identification of distinct networks of interstitial cells. BJU Int 2004;94(7):1114-24.
103. 2+ signals in detrusor smooth muscles of the guinea-pig urinary' bladder. J Physiol 2004;559(Pt 2):567-81.
104. Sui GP, Wu C, Fry CH. Electrical characteristics of suburothelial cells isolated from the human bladder. J Urol 2004;171(2 Pt 1):938-43.
105. Sui GP, Rothery S, Dupont E, Fry CH, Severs NJ. Gap junctions and connexin expression in human suburothelial interstitial cells. BJU Int 2002;90(1):118-29.
106. Ferguson DR, Kennedy I, Burton TJ. ATP is released from rabbit urinary bladder epithelial cells by hydrostatic pressure changes-a possible sensory mechanism? J Physiol 1997;505(Pt 2):503-11.
107. Gillespie JI. The autonomous bladder: a view of the origin of bladder overactivity and sensory urge. BJU Int 2004;93(4):478-83.
108. Gillespie J, Harvey I, Drake M: Agonist and nerve-induced phasic activity in the isolated whole bladder of the guinea pig: evidence for two types of bladder activity. Exp Physiol 2003;88:343-57.
109. Gillespie JI. Noradrenaline inhibits autonomous activity in the isolated guinea pig bladder. BJU Int 2004;93:401-9.
110. Gillespie J: Inhibitory actions of calcitonin gene-related peptide and capsaicin: evidence for local axonal reflexes in the bladder wall. BJU Int 2005;95:149-56.
111. Gillespie JI: Phosphodiesterase-linked inhibition of nonmicturition activity in the isolated bladder. BJU Int 2004;93:1325-32.
112. Gillespie JI, Drake MJ. The actions of sodium nitroprusside and the phosphodiesterase inhibitor dipyridamole on phasic activity in the isolated guinea-pig bladder. BJU Int 2004;93:851-8.
113. Gillespie JI: Modulation of autonomous contractile activity in the isolated whole bladder of the guinea pig. BJU Int 2004;93:393-400.
114. Gillespie J: Inhibitory actions of calcitonin gene-related peptide and capsaicin: evidence for local axonal reflexes in the bladder wall. BJU Int 2005;95:149-56.
115. Lagou M, Drake MJ, Gillespie JI. Volume-induced effects on the isolated bladder: a possible local reflex. BJU Int 2004;94:1356-65.
116. Kubota Y, Kajioka S, Biers SM et al. Investigation of the effect of the c-kit inhibitor Glivec on isolated guinea-pig detrusor preparations. Autonomic Neuroscience 2004;115:64-73.
117. Rovner ES, Wein AJ. Incidence and prevalence of overactive bladder. Curr Urol Rep 2002;3:434-8.
118. Wein AJ. Diagnosis and treatment of the overactive bladder. Urology 2003;62 (Suppl 5b):20-27.
119. Fantl JA, Wyman JF, McClish DK et al. Efficacy of bladder training in older women with urinary incontinence. JAMA 1991;265(5):609-13.
120. Andersson KE. Treatment of the overactive bladder: possible central nervous system drug targets. Urology 2002;59 (Suppl 1):18-24.
121. Kachur JF, Peterson JS, Carter JP et al. R and S enantiomers of oxybutynin: pharmacological effects in guinea pig bladder and intestine. J Pharmacol Exp Ther 1988;247(3):867-72.
122. Nilvebrant L, Andersson K.E, Gillberg P.G. et al. Tolterodine: a new bladder selective antimuscarinic agent. Eur J Pharmacol 1997;327:195-207.
123. Waldeck K, Larsson B, Andersson K.E. Comparison of oxybutynin and its active metabolite, N-desethyl-oxybutynin, in the human detrusor and parotid gland. J Urol 1997;157:1093-7.
124. Birns J, Lukkari E, Malone Lee JG. A randomized controlled trial comparing the efficacy of controlled-release oxybutynin tablets (10 mg once daily) with conventional oxybutynin tablets (5 mg twice daily) in patients whose symptoms were stabilized on 5 mg twice daily of oxybutynin. BJU Int 2000;85:793-8.
125. Appell RA. Clinical efficacy and safety of tolterodine in the treatment of overactive bladder: a pooled analysis. Urology 1997;50 (Suppl):90-6.
126. Drutz H, Appell RA, Gleason D et al. Clinical efficacy and safety of tolterodine compared to oxybutynin and placebo in patients with overactive bladder. Int Urogynecol J Pelvic Floor Dysfunct 1999;10(5):283-9.
127. Kobelt G, Jönsson L and Mattiasson A. Cost-effectiveness of new treatments for overactive bladder: the example of tolterodine, a new muscarinic agent: a Markov model. Neurourol Urodyn 1998;17:599-611.
128. Chapple CR, Nilvebrant L. Tolterodine: selectivity for the urinary bladder over the eye (as measured by visual accommodation) in healthy volunteers. Drugs RD 2002;3(2):75-81.
129. Chapple CR, Rechberger T, Al-Shukri S et al; YM-905 Study Group. Randomized, double-blind placebo- and tolterodine-controlled trial of the once-daily antimuscarinic agent solifenacin in patients with symptomatic overactive bladder. BJU Int 2004;93(3):303-10.
130. Chapple CR, Martinez-Garcia R, Selvaggi L et al; for the STAR study group. A Comparison of the Efficacy and Tolerability of Solifenacin Succinate and Extended Release Tolterodine at Treating Overactive Bladder Syndrome: Results of the STAR Trial. Eur Urol 2005;48(3):464-70.
131. Kelleher CJ, Cardozo L, Chapple CR et al. Improved quality of life in patients with overactive bladder symptoms treated with solifenacin. BJU Int 2005;95(1):81-5.
132. Gillberg PG, Sundquist S, Nilvebrant L. Comparison of the in vitro and in vivo profiles of tolterodine with those of subtype-selective muscarinic receptor antagonists. Eur J Pharmacol 1998;349:285-92.
133. Newgreen DT, Anderson CWP, Carter AJ et al. Darifenacin: a novel bladder-selective agent for the treatment of urge incontinence. Neurourol Urodyn 1995;14:555-7.
134. Wallis RM, Napier CM. Muscarinic antagonists in development for disorders of smooth muscle function. Life Sci 1999;64:395-401.
135. Chapple C, Steers W, Norton P et al. A pooled analysis of three phase III studies to investigate the efficacy, tolerability and safety of darifenacin, a muscarinic M3 selective receptor antagonist, in the treatment of overactive bladder. BJU Int 2005;95(7):993-1001.
136. Chapple CR, Abrams P. Comparison of darifenacin and oxybutynin in patients with overactive bladder: assessment of ambulatory urodynamics and impact on salivary flow. Eur Urol 2005;48(1):102-9.
137. Gunnarsson M, Teleman P, Mattiasson A et al. Effects of pelvic floor exercises in middle aged women with a history of naive urinary incontinence: a population based study. Eur Urol 2002;41(5):556-61.
138. Berghmans B, van Waalwijk van Doom E, Nieman F et al. Efficacy of physical therapeutic modalities in women with proven bladder overactivity. Eur Urol 2002;41(6):581-7.
139. Kalsi V, Apostolidis A, Popat R et al. Quality of life changes in patients with neurogenic versus idiopathic detrusor overactivity after intradetrusor injections of botulinum neurotoxin type A and correlations with lower urinary tract symptoms and urodynamic changes. Eur Urol 2006;49 (3):528-35.
140. Reitz A, Stohrer M, Kramer G et al. European experience of 200 cases treated with botulinum-A toxin injections into the detrusor muscle for urinary incontinence due to neurogenic detrusor overactivity. Eur Urol 2004;45 (4):510-5.
141. Silva C, Silva J, Ribeiro MJ, Avelino A, Cruz F. Urodynamic effect of intravesical resiniferatoxin in patients with neurogenic detrusor overactivity of spinal origin: results of a double-blind randomized placebo-controlled trial. Eur Urol 2005;48(4):650-5.
142. Scheepens WA, van Koeveringe GA, de Bie RA et al. Urodynamic results of sacral neuromodulation correlate with subjective improvement in patients with an overactive bladder. Eur Urol 2003;43(3):282-7.
143. Janknegt RA, Hassouna MM, Siegel SW et al. Long-term effectiveness of sacral nerve stimulation for refractory urge incontinence. Eur Urol 2001;39 (1):101-6.