Improved blood-brain barrier penetration and enhanced analgesia of an opioid peptide by glycosylation

Journal of Pharmacology and Experimental Therapeutics

Volumn 299, Issue 3, 2001, Pages 967-972

  Egleton, R D ^b   Mitchell, S A ^a,c   Huber, J D ^b   Palian, M M ^c   Polt, R ^c   Davis, T P ^b  

^a NEUROGEN CORPORATION   (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^c University of Arizona   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROPEPTIDE; OPIATE PEPTIDE; TYROSYL DEXTRO THREONYLGLYCYLPHENYLALANYLLEUCYLSERINAMIDE; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG MECHANISM; DRUG METABOLISM; DRUG STRUCTURE; DRUG TRANSPORT; ENZYME STABILITY; GLYCOSYLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOUSE; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; RAT; TAIL FLICK TEST;

ANALGESICS, OPIOID; ANIMALS; BLOOD-BRAIN BARRIER; DRUG STABILITY; ENKEPHALIN, LEUCINE; GLYCOSYLATION; MALE; MICE; MICE, INBRED ICR; OPIOID PEPTIDES; PAIN; PERFUSION;

EID: 0035200718     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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