메뉴 건너뛰기




Volumn 2, Issue 2, 2006, Pages 117-123

Fitness or fatness: The debate continues for AMP-activated protein kinase in heart function

Author keywords

AMP activated protein kinase; Cardiac; Contraction; Hypertrophy

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADENYLATE KINASE; ADIPOCYTOKINE; ADIPONECTIN; CYCLOOXYGENASE 2; ELONGATION FACTOR 2; FATTY ACID; GLUCOSE; GLYCOGEN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LEPTIN; MITOGEN ACTIVATED PROTEIN KINASE P38; TUBERIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 33746133584     PISSN: 15733947     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340306777013574     Document Type: Review
Times cited : (2)

References (62)
  • 1
    • 4344682934 scopus 로고    scopus 로고
    • AMP-activated protein kinase: The guardian of cardiac energy status
    • Hardie DG. AMP-activated protein kinase: the guardian of cardiac energy status. J Clin Invest 2004; 114(4):465-468.
    • (2004) J Clin Invest , vol.114 , Issue.4 , pp. 465-468
    • Hardie, D.G.1
  • 2
    • 0029910018 scopus 로고    scopus 로고
    • Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase
    • Hawley SA, Davison M, Woods A, Davies SP, Beri RK, Carling D et al. Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase. J Biol Chem 1996; 271(44):27879-27887.
    • (1996) J Biol Chem , vol.271 , Issue.44 , pp. 27879-27887
    • Hawley, S.A.1    Davison, M.2    Woods, A.3    Davies, S.P.4    Beri, R.K.5    Carling, D.6
  • 3
    • 0031007065 scopus 로고    scopus 로고
    • The AMP-activated protein kinase-fuel gauge of the mammalian cell?
    • Hardie DG, Carling D. The AMP-activated protein kinase-fuel gauge of the mammalian cell? Eur J Biochem 1997; 246(2):259-273.
    • (1997) Eur J Biochem , vol.246 , Issue.2 , pp. 259-273
    • Hardie, D.G.1    Carling, D.2
  • 4
    • 0036750019 scopus 로고    scopus 로고
    • Is creatine kinase a target for ANT-activated protein kinase in the heart?
    • Ingwall JS. Is creatine kinase a target for ANT-activated protein kinase in the heart? J Mol Cell Cardiol 2002; 34(9):1111-1120.
    • (2002) J Mol Cell Cardiol , vol.349 , pp. 1111-1120
    • Ingwall, J.S.1
  • 5
    • 15044358594 scopus 로고    scopus 로고
    • New roles for the LKB1->AMPK pathway
    • Hardie DG. New roles for the LKB1->AMPK pathway. Curr Opin Cell Biol 2005; 17(2):167-173.
    • (2005) Curr Opin Cell Biol , vol.17 , Issue.2 , pp. 167-173
    • Hardie, D.G.1
  • 6
    • 0345107247 scopus 로고    scopus 로고
    • Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
    • Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Makela TP et al. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol 2003; 2(4):28.
    • (2003) J Biol , vol.2 , Issue.4 , pp. 28
    • Hawley, S.A.1    Boudeau, J.2    Reid, J.L.3    Mustard, K.J.4    Udd, L.5    Makela, T.P.6
  • 7
    • 1842484296 scopus 로고    scopus 로고
    • AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
    • Minokoshi Y, Alquier T, Furukawa N, Kim YB, Lee A, Xue B et al. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 2004; 428(6982):569-574.
    • (2004) Nature , vol.428 , Issue.6982 , pp. 569-574
    • Minokoshi, Y.1    Alquier, T.2    Furukawa, N.3    Kim, Y.B.4    Lee, A.5    Xue, B.6
  • 8
    • 33645964962 scopus 로고    scopus 로고
    • Effect of dietary alpha-lipoic acid on growth, body composition, muscle pH, and AMP-activated protein kinase phosphorylation in mice
    • Shen QW, Jones CS, Kalchayanand N, Zhu MJ, Du M. Effect of dietary alpha-lipoic acid on growth, body composition, muscle pH, and AMP-activated protein kinase phosphorylation in mice. J Anim Sci 2005; 83(11):2611-2617.
    • (2005) J Anim Sci , vol.83 , Issue.11 , pp. 2611-2617
    • Shen, Q.W.1    Jones, C.S.2    Kalchayanand, N.3    Zhu, M.J.4    Du, M.5
  • 9
  • 10
    • 0141569397 scopus 로고    scopus 로고
    • Mutation analysis of AMP-activated protein kinase subunits in inherited cardiomyopathics: Implications for kinase function and disease pathogenesis
    • Oliveira SM, Ehtisham J, Redwood CS, Ostman-Smith I, Blair EM, Watkins H. Mutation analysis of AMP-activated protein kinase subunits in inherited cardiomyopathics: implications for kinase function and disease pathogenesis. J Mol Cell Cardiol 2003; 35(10):1251-1255.
    • (2003) J Mol Cell Cardiol , vol.35 , Issue.10 , pp. 1251-1255
    • Oliveira, S.M.1    Ehtisham, J.2    Redwood, C.S.3    Ostman-Smith, I.4    Blair, E.M.5    Watkins, H.6
  • 11
    • 33644874700 scopus 로고    scopus 로고
    • Increased alpha2 subunit-associated AMPK activity and PRKAG2 cardiomyopathy
    • Ahmad F, Arad M, Musi N, He H, Wolf C, Branco D et al. Increased alpha2 subunit-associated AMPK activity and PRKAG2 cardiomyopathy. Circulation 2005; 112(20):3140-3148.
    • (2005) Circulation , vol.112 , Issue.20 , pp. 3140-3148
    • Ahmad, F.1    Arad, M.2    Musi, N.3    He, H.4    Wolf, C.5    Branco, D.6
  • 12
    • 0035872209 scopus 로고    scopus 로고
    • Mutations in the gamma(2) subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: Evidence for the central role of energy compromise in disease pathogenesis
    • Blair E, Redwood C, Ashrafian H, Oliveira M, Broxholme J, Kerr B et al. Mutations in the gamma(2) subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence for the central role of energy compromise in disease pathogenesis. Hum Mol Genet 2001; 10(11):1215-1220.
    • (2001) Hum Mol Genet , vol.10 , Issue.11 , pp. 1215-1220
    • Blair, E.1    Redwood, C.2    Ashrafian, H.3    Oliveira, M.4    Broxholme, J.5    Kerr, B.6
  • 13
    • 19944429566 scopus 로고    scopus 로고
    • Transgenic mouse model of ventricular preexcitation and atrioventricular reentrant tachycardia induced by an AMP-activated protein kinase loss-of-function mutation responsible for Wolff-Parkinson-White syndrome
    • Sidhu JS, Rajawat YS, Rami TG, Gollob MH, Wang Z, Yuan R et al. Transgenic mouse model of ventricular preexcitation and atrioventricular reentrant tachycardia induced by an AMP-activated protein kinase loss-of-function mutation responsible for Wolff-Parkinson-White syndrome. Circulation 2005; 111(1):21-29.
    • (2005) Circulation , vol.111 , Issue.1 , pp. 21-29
    • Sidhu, J.S.1    Rajawat, Y.S.2    Rami, T.G.3    Gollob, M.H.4    Wang, Z.5    Yuan, R.6
  • 14
    • 18744400529 scopus 로고    scopus 로고
    • Exogenous nitric oxide reduces glucose transporters translocation and lactate production in ischemic myocardium in vivo
    • Lei B, Matsuo K, Labinskyy V, Sharma N, Chandler MP, Ahn A et al. Exogenous nitric oxide reduces glucose transporters translocation and lactate production in ischemic myocardium in vivo. Proc Natl Acad Sci U S A 2005; 102(19):6966-6971.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , Issue.19 , pp. 6966-6971
    • Lei, B.1    Matsuo, K.2    Labinskyy, V.3    Sharma, N.4    Chandler, M.P.5    Ahn, A.6
  • 16
    • 78149279712 scopus 로고    scopus 로고
    • AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury
    • Russell RR, III, Li J, Coven DL, Pypaert M, Zechner C, Palmeri M et al. AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury. J Clin Invest 2004; 114(4):495-503.
    • (2004) J Clin Invest , vol.114 , Issue.4 , pp. 495-503
    • Russell III, R.R.1    Li, J.2    Coven, D.L.3    Pypaert, M.4    Zechner, C.5    Palmeri, M.6
  • 17
    • 20044391423 scopus 로고    scopus 로고
    • Adenosine monophosphate-activated protein kinase disease mimicks hypertrophic cardiomyopathy and Wolff-Parkinson-White syndrome: Natural history
    • Murphy RT, Mogensen J, McGarry K, Bahl A, Evans A, Osman E et al. Adenosine monophosphate-activated protein kinase disease mimicks hypertrophic cardiomyopathy and Wolff-Parkinson-White syndrome: natural history. J Am Coll Cardiol 2005; 45(6):922-930.
    • (2005) J Am Coll Cardiol , vol.45 , Issue.6 , pp. 922-930
    • Murphy, R.T.1    Mogensen, J.2    McGarry, K.3    Bahl, A.4    Evans, A.5    Osman, E.6
  • 18
    • 20144387673 scopus 로고    scopus 로고
    • Functional role of AMP-activated protein kinase in the heart during exercise
    • Musi N, Hirshman MF, Arad M, Xing Y, Fujii N, Pomerleau J et al. Functional role of AMP-activated protein kinase in the heart during exercise. FEBS Lett 2005; 579(10):2045-2050.
    • (2005) FEBS Lett , vol.579 , Issue.10 , pp. 2045-2050
    • Musi, N.1    Hirshman, M.F.2    Arad, M.3    Xing, Y.4    Fujii, N.5    Pomerleau, J.6
  • 19
    • 20844451123 scopus 로고    scopus 로고
    • AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
    • Kahn BB, Alquier T, Carling D, Hardie DG. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 2005; 1(1): 15-25.
    • (2005) Cell Metab , vol.1 , Issue.1 , pp. 15-25
    • Kahn, B.B.1    Alquier, T.2    Carling, D.3    Hardie, D.G.4
  • 20
    • 22744449914 scopus 로고    scopus 로고
    • Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism
    • Liao Y, Takashima S, Maeda N, Ouchi N, Komamura K, Shimomura I et al. Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism Cardiovasc Res 2005; 67(4):705-713.
    • (2005) Cardiovasc Res , vol.67 , Issue.4 , pp. 705-713
    • Liao, Y.1    Takashima, S.2    Maeda, N.3    Ouchi, N.4    Komamura, K.5    Shimomura, I.6
  • 21
    • 0031907281 scopus 로고    scopus 로고
    • Pathological versus physiological left ventricular hypertrophy: A review
    • Richey PA, Brown SP. Pathological versus physiological left ventricular hypertrophy: a review. J Sports Sci 1998; 16(2):129-141.
    • (1998) J Sports Sci , vol.16 , Issue.2 , pp. 129-141
    • Richey, P.A.1    Brown, S.P.2
  • 22
    • 0034713820 scopus 로고    scopus 로고
    • Left ventricular hypertrophy: Pathogenesis, detection, and prognosis
    • Lorell BH, Carabello BA. Left ventricular hypertrophy: pathogenesis, detection, and prognosis. Circulation 2000; 102(4):470-479.
    • (2000) Circulation , vol.102 , Issue.4 , pp. 470-479
    • Lorell, B.H.1    Carabello, B.A.2
  • 24
    • 0002537440 scopus 로고    scopus 로고
    • Cardiac hypertrophy: The good, the bad, and the ugly
    • Frey N, Olson EN. Cardiac hypertrophy: the good, the bad, and the ugly. Annu Rev Physiol 2003; 65:45-79.
    • (2003) Annu Rev Physiol , vol.65 , pp. 45-79
    • Frey, N.1    Olson, E.N.2
  • 25
    • 0035797839 scopus 로고    scopus 로고
    • Increased adenosine monophosphate-activated protein kinase activity in rat hearts with pressure-overload hypertrophy
    • Tian R, Musi N, D'Agostino J, Hirshman MF, Goodyear LJ. Increased adenosine monophosphate-activated protein kinase activity in rat hearts with pressure-overload hypertrophy. Circulation 2001; 104(14):1664-1669.
    • (2001) Circulation , vol.104 , Issue.14 , pp. 1664-1669
    • Tian, R.1    Musi, N.2    D'Agostino, J.3    Hirshman, M.F.4    Goodyear, L.J.5
  • 26
    • 0035859215 scopus 로고    scopus 로고
    • Identification of a gene responsible for familial Wolff-Parkinson-White syndrome
    • Gollob MH, Green MS, Tang AS, Gollob T, Karibe A, Ali Hassan AS et al. Identification of a gene responsible for familial Wolff-Parkinson-White syndrome. N Engl J Med 2001; 344(24):1823-1831.
    • (2001) N Engl J Med , vol.344 , Issue.24 , pp. 1823-1831
    • Gollob, M.H.1    Green, M.S.2    Tang, A.S.3    Gollob, T.4    Karibe, A.5    Ali Hassan, A.S.6
  • 27
    • 0036167225 scopus 로고    scopus 로고
    • Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy
    • Arad M, Benson DW, Perez-Atayde AR, McKenna WJ, Sparks EA, Kantor RJ et al. Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy. J Clin Invest 2002; 109(3):357-362.
    • (2002) J Clin Invest , vol.109 , Issue.3 , pp. 357-362
    • Arad, M.1    Benson, D.W.2    Perez-Atayde, A.R.3    McKenna, W.J.4    Sparks, E.A.5    Kantor, R.J.6
  • 28
    • 3543008912 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte
    • Chan AY, Soltys CL, Young ME, Proud CG, Dyck JR. Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte. J Biol Chem 2004; 279(31):32771-32779.
    • (2004) J Biol Chem , vol.279 , Issue.31 , pp. 32771-32779
    • Chan, A.Y.1    Soltys, C.L.2    Young, M.E.3    Proud, C.G.4    Dyck, J.R.5
  • 29
    • 1642328617 scopus 로고    scopus 로고
    • Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398
    • Browne GJ, Finn SG, Proud CG. Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398. J Biol Chem 2004; 279(13):12220-12231.
    • (2004) J Biol Chem , vol.279 , Issue.13 , pp. 12220-12231
    • Browne, G.J.1    Finn, S.G.2    Proud, C.G.3
  • 30
    • 1642355123 scopus 로고    scopus 로고
    • A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin
    • Browne GJ, Proud CG. A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin. Mol Cell Biol 2004; 24(7):2986-2997.
    • (2004) Mol Cell Biol , vol.24 , Issue.7 , pp. 2986-2997
    • Browne, G.J.1    Proud, C.G.2
  • 31
    • 1942469564 scopus 로고    scopus 로고
    • Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status
    • Cheng SW, Fryer LG, Carling D, Shepherd PR. Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status. J Biol Chem 2004; 279(16):15719-15722.
    • (2004) J Biol Chem , vol.279 , Issue.16 , pp. 15719-15722
    • Cheng, S.W.1    Fryer, L.G.2    Carling, D.3    Shepherd, P.R.4
  • 32
    • 19944408988 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinase (AMPK) inhibits protein synthesis: A potential strategy to prevent the development of cardiac hypertrophy
    • Chan AY, Dyck JR. Activation of AMP-activated protein kinase (AMPK) inhibits protein synthesis: a potential strategy to prevent the development of cardiac hypertrophy. Can J Physiol Pharmacol 2005; 83(1):24-28.
    • (2005) Can J Physiol Pharmacol , vol.83 , Issue.1 , pp. 24-28
    • Chan, A.Y.1    Dyck, J.R.2
  • 33
    • 0036438894 scopus 로고    scopus 로고
    • Regulation of peptide-chain elongation in mammalian cells
    • Browne GJ, Proud CG. Regulation of peptide-chain elongation in mammalian cells. Eur J Biochem 2002; 269(22):5360-5368.
    • (2002) Eur J Biochem , vol.269 , Issue.22 , pp. 5360-5368
    • Browne, G.J.1    Proud, C.G.2
  • 34
    • 0023884601 scopus 로고
    • Phosphorylation of elongation factor 2 by EF-2 kinase affects rate of translation
    • Ryazanov AG, Shestakova EA, Natapov PG. Phosphorylation of elongation factor 2 by EF-2 kinase affects rate of translation. Nature 1988; 334(6178):170-173.
    • (1988) Nature , vol.334 , Issue.6178 , pp. 170-173
    • Ryazanov, A.G.1    Shestakova, E.A.2    Natapov, P.G.3
  • 35
    • 0024365118 scopus 로고
    • Mechanism of elongation factor 2 (EF-2) inactivation upon phosphorylation. Phosphorylated EF-2 is unable to catalyze translocation
    • Ryazanov AG, Davydova EK. Mechanism of elongation factor 2 (EF-2) inactivation upon phosphorylation. Phosphorylated EF-2 is unable to catalyze translocation. FEBS Lett 1989; 251(1-2):187-190.
    • (1989) FEBS Lett , vol.251 , Issue.1-2 , pp. 187-190
    • Ryazanov, A.G.1    Davydova, E.K.2
  • 37
    • 0025003542 scopus 로고
    • Functional properties of phosphorylated elongation factor 2
    • Carlberg U, Nilsson A, Nygard O. Functional properties of phosphorylated elongation factor 2. Eur J Biochem 1990; 191(3):639-645.
    • (1990) Eur J Biochem , vol.191 , Issue.3 , pp. 639-645
    • Carlberg, U.1    Nilsson, A.2    Nygard, O.3
  • 39
    • 0035881737 scopus 로고    scopus 로고
    • A novel method to identify protein kinase substrates: EEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta
    • Knebel A, Morrice N, Cohen P. A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/ p38delta. EMBO J 2001; 20(16):4360-4369.
    • (2001) EMBO J , vol.20 , Issue.16 , pp. 4360-4369
    • Knebel, A.1    Morrice, N.2    Cohen, P.3
  • 40
    • 0037109036 scopus 로고    scopus 로고
    • Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and -insensitive pathways
    • Knebel A, Haydon CE, Morrice N, Cohen P. Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and -insensitive pathways. Biochem J 2002; 367(Pt 2):525-532.
    • (2002) Biochem J , vol.367 , Issue.PART 2 , pp. 525-532
    • Knebel, A.1    Haydon, C.E.2    Morrice, N.3    Cohen, P.4
  • 41
    • 0035881470 scopus 로고    scopus 로고
    • Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase
    • Wang X, Li W, William M, Terada N, Alessi DR, Proud CG. Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase. EMBO J 2001; 20(16):4370-4379.
    • (2001) EMBO J , vol.20 , Issue.16 , pp. 4370-4379
    • Wang, X.1    Li, W.2    William, M.3    Terada, N.4    Alessi, D.R.5    Proud, C.G.6
  • 42
    • 0142149149 scopus 로고    scopus 로고
    • Myocardial ischemia and increased heart work modulate the phosphorylation state of eukaryotic elongation factor-2
    • Horman S, Beauloye C, Vertommen D, Vanoverschelde JL, Hue L, Rider MH. Myocardial ischemia and increased heart work modulate the phosphorylation state of eukaryotic elongation factor-2. J Biol Chem 2003; 278(43):41970-41976.
    • (2003) J Biol Chem , vol.278 , Issue.43 , pp. 41970-41976
    • Horman, S.1    Beauloye, C.2    Vertommen, D.3    Vanoverschelde, J.L.4    Hue, L.5    Rider, M.H.6
  • 43
    • 0037143449 scopus 로고    scopus 로고
    • Activation of AMP-activated protein kinasia leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis
    • Horman S, Browne G, Krause U, Patel J, Vertommen D, Bertrand L et al. Activation of AMP-activated protein kinasia leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis. Curr Biol 2002; 12(16):1419-1423.
    • (2002) Curr Biol , vol.12 , Issue.16 , pp. 1419-1423
    • Horman, S.1    Browne, G.2    Krause, U.3    Patel, J.4    Vertommen, D.5    Bertrand, L.6
  • 44
    • 27144489669 scopus 로고    scopus 로고
    • AMP-activated protein kinase protects cardiomyocytes against hypoxic injury through attenuation of endoplasmic reticulum stress
    • Terai K, Hiramoto Y, Masaki M, Sugiyama S, Kuroda T, Hori M et al. AMP-activated protein kinase protects cardiomyocytes against hypoxic injury through attenuation of endoplasmic reticulum stress. Mol Cell Biol 2005; 25(21):9554-9575.
    • (2005) Mol Cell Biol , vol.25 , Issue.21 , pp. 9554-9575
    • Terai, K.1    Hiramoto, Y.2    Masaki, M.3    Sugiyama, S.4    Kuroda, T.5    Hori, M.6
  • 45
    • 0035312747 scopus 로고    scopus 로고
    • Regulation of translation initiation by FRAP/mTOR
    • Gingras AC, Raught B, Sonenberg N. Regulation of translation initiation by FRAP/mTOR. Crones Dev 2001; 15(7):807-826.
    • (2001) Crones Dev , vol.15 , Issue.7 , pp. 807-826
    • Gingras, A.C.1    Raught, B.2    Sonenberg, N.3
  • 46
    • 15044350668 scopus 로고    scopus 로고
    • The expanding TOR signaling network
    • Martin DE, Hall MN. The expanding TOR signaling network. Curr Opin Cell Biol 2005; 17(2):158-166.
    • (2005) Curr Opin Cell Biol , vol.17 , Issue.2 , pp. 158-166
    • Martin, D.E.1    Hall, M.N.2
  • 47
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev 2004; 18(16):1926-1945.
    • (2004) Genes Dev , vol.18 , Issue.16 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 48
    • 0037025356 scopus 로고    scopus 로고
    • AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling
    • Bolster DR, Crozier SJ, Kimball SR, Jefferson LS. AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling. J Biol Chem 2062; 277(27):23977-23980.
    • (2062) J Biol Chem , vol.277 , Issue.27 , pp. 23977-23980
    • Bolster, D.R.1    Crozier, S.J.2    Kimball, S.R.3    Jefferson, L.S.4
  • 49
    • 1942469564 scopus 로고    scopus 로고
    • Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status
    • Cheng SW, Fryer LG, Carling D, Shepherd PR. Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status. J Biol Chem 2004; 279(16):15719-15722.
    • (2004) J Biol Chem , vol.279 , Issue.16 , pp. 15719-15722
    • Cheng, S.W.1    Fryer, L.G.2    Carling, D.3    Shepherd, P.R.4
  • 50
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003; 115(5):577-590.
    • (2003) Cell , vol.115 , Issue.5 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 51
    • 0037683087 scopus 로고    scopus 로고
    • Tumour suppressors hamartin and tuberin: Intracellular signalling
    • Krymskaya VP. Tumour suppressors hamartin and tuberin: intracellular signalling. Cell Signal 2003; 15(8):729-739.
    • (2003) Cell Signal , vol.15 , Issue.8 , pp. 729-739
    • Krymskaya, V.P.1
  • 52
    • 0038433304 scopus 로고    scopus 로고
    • Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
    • Garami A. Zwartkruis FJ, Nobukuni T, Joaquin M, Roccio M, Stocker H et al. Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol Cell 2003; 11(6):1457-1466.
    • (2003) Mol Cell , vol.11 , Issue.6 , pp. 1457-1466
    • Garami, A.1    Zwartkruis, F.J.2    Nobukuni, T.3    Joaquin, M.4    Roccio, M.5    Stocker, H.6
  • 53
    • 0041758428 scopus 로고    scopus 로고
    • Tuberous sclerosis: From tubers to mTOR
    • Kwiatkowski DJ. Tuberous sclerosis: from tubers to mTOR. Ann Hum Genet 2003; 67(Pt 1):87-96.
    • (2003) Ann Hum Genet , vol.67 , Issue.PART 1 , pp. 87-96
    • Kwiatkowski, D.J.1
  • 54
    • 18044389727 scopus 로고    scopus 로고
    • AMP-activated protein kinase and the metabolic syndrome
    • Fryer LG, Carling D. AMP-activated protein kinase and the metabolic syndrome. Biochem Soc Trans 2005; 33(Pt 2):362-366.
    • (2005) Biochem Soc Trans , vol.33 , Issue.PART 2 , pp. 362-366
    • Fryer, L.G.1    Carling, D.2
  • 55
    • 20144386698 scopus 로고    scopus 로고
    • Long-term AICAR administration and exercise prevents diabetes in ZDF rats
    • Pold R, Jensen LS, Jessen N, Buhl ES, Schmitz O, Flyvbjerg A et al. Long-term AICAR administration and exercise prevents diabetes in ZDF rats. Diabetes 2005; 54(4):928-934.
    • (2005) Diabetes , vol.54 , Issue.4 , pp. 928-934
    • Pold, R.1    Jensen, L.S.2    Jessen, N.3    Buhl, E.S.4    Schmitz, O.5    Flyvbjerg, A.6
  • 56
    • 28044464932 scopus 로고    scopus 로고
    • Over-expression of AMP-activated protein kinase impairs pancreatic {beta}-cell function in vivo
    • Richards SK, Parton LE, Leclerc I, Rutter GA, Smith RM. Over-expression of AMP-activated protein kinase impairs pancreatic {beta}-cell function in vivo. J Endocrinol 2005; 187(2):225-235.
    • (2005) J Endocrinol , vol.187 , Issue.2 , pp. 225-235
    • Richards, S.K.1    Parton, L.E.2    Leclerc, I.3    Rutter, G.A.4    Smith, R.M.5
  • 57
    • 17444412257 scopus 로고    scopus 로고
    • Metabolic effects of insulin on cardiomyocytes from control and diabetic db/db mouse hearts
    • Carroll R, Carley AN, Dyck JR, Severson DL. Metabolic effects of insulin on cardiomyocytes from control and diabetic db/db mouse hearts. Am J Physiol Endocrinol Metab 2005; 288(5):E900-E906.
    • (2005) Am J Physiol Endocrinol Metab , vol.288 , Issue.5
    • Carroll, R.1    Carley, A.N.2    Dyck, J.R.3    Severson, D.L.4
  • 58
    • 27644477357 scopus 로고    scopus 로고
    • AMP-activated protein kinase activates p38 mitogen-activated protein kinase by increasing recruitment of p38 MAPK to TAB1 in the ischemic heart
    • Li J, Miller EJ, Ninomiya-Tsuji J, Russell RR, III, Young LH. AMP-activated protein kinase activates p38 mitogen-activated protein kinase by increasing recruitment of p38 MAPK to TAB1 in the ischemic heart. Circ Res 2005; 97(9):872-879.
    • (2005) Circ Res , vol.97 , Issue.9 , pp. 872-879
    • Li, J.1    Miller, E.J.2    Ninomiya-Tsuji, J.3    Russell III, R.R.4    Young, L.H.5
  • 59
    • 21144431521 scopus 로고    scopus 로고
    • beta-Agonist stimulation produces changes in cardiac AMPK and coronary lumen LPL only during increased workload
    • An D, Kewalramani G, Qi D, Pulinilkunnil T, Ghosh S, Abrehani A et al. beta-Agonist stimulation produces changes in cardiac AMPK and coronary lumen LPL only during increased workload. Am J Physiol Endocrinol Metab 2005; 288(6):E1120-E1127.
    • (2005) Am J Physiol Endocrinol Metab , vol.288 , Issue.6
    • An, D.1    Kewalramani, G.2    Qi, D.3    Pulinilkunnil, T.4    Ghosh, S.5    Abrehani, A.6
  • 60
    • 27144511497 scopus 로고    scopus 로고
    • AICAR stimulates IL-6 production via p38 MAPK in cardiac fibroblasts in adult mice: A possible role for AMPK
    • Du JH, Xu N, Song Y, Xu M, Lu ZZ, Han C et al. AICAR stimulates IL-6 production via p38 MAPK in cardiac fibroblasts in adult mice: a possible role for AMPK. Biochem Biophys Res Commum 2005; 337(4):1139-1144.
    • (2005) Biochem Biophys Res Commum , vol.337 , Issue.4 , pp. 1139-1144
    • Du, J.H.1    Xu, N.2    Song, Y.3    Xu, M.4    Lu, Z.Z.5    Han, C.6
  • 61
    • 19944369735 scopus 로고    scopus 로고
    • Adiponectin-mediated modulation of hypertrophic signals in the heart
    • Shibata R, Ouchi N, Ito M, Kihara S, Shiojima I, Pimentel DR et al. Adiponectin-mediated modulation of hypertrophic signals in the heart. Nat Med 2004; 10(12):1384-1389.
    • (2004) Nat Med , vol.10 , Issue.12 , pp. 1384-1389
    • Shibata, R.1    Ouchi, N.2    Ito, M.3    Kihara, S.4    Shiojima, I.5    Pimentel, D.R.6
  • 62
    • 27144457438 scopus 로고    scopus 로고
    • Adiponectin protects against myocardial ischemia-reperfusion injury through
    • Shibata R, Sato K, Pimentel DR, Takemura Y, Kihara S, Ohashi K et al. Adiponectin protects against myocardial ischemia-reperfusion injury through. Nat Med 2005; 11:1096-1103.
    • (2005) Nat Med , vol.11 , pp. 1096-1103
    • Shibata, R.1    Sato, K.2    Pimentel, D.R.3    Takemura, Y.4    Kihara, S.5    Ohashi, K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.