Antiestrogenically active 2-benzyl-1,1-diarylbut-2-enes: Synthesis structure-activity relationships and molecular modeling study for flexible estrogen receptor antagonists

Medicinal Chemistry

Volumn 2, Issue 2, 2006, Pages 147-168

  Lloyd, David G ^a   Smith, Helena M ^a   O'Sullivan, Timothy ^a   Knox, Andrew S ^a   Zisterer, Daniela M ^a   Meegan, Mary J ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Anticancer drugs; Antiestrogens; Estrogen receptor modulators; Structure activity relationships

Indexed keywords

1 [2 [4 [2 (4 HYDROXYBENZYL) 1 (4 HYDROXYPHENYL)BUT 1 ENYL]PHENOXY]ETHYL]PYRROLIDIN 2 ONE; 2 BENZYL 1,1 DIARYLBUT 2 ENE DERIVATIVE; 2,2 DIMETHYLPROPIONIC ACID 2 (2' OXOBUTYL)PHENYL ESTER; 2,2 DIMETHYLPROPIONIC ACID 2 [2 ETHYL 3 (4 HYDROXYPHENYL) 3 [4 (2 PYRROLIDIN 1 YL ETHOXY)PHENYL]ALLYL]PHENYL ESTER; 2,2 DIMETHYLPROPIONIC ACID 3 (2' OXO BUTYL)PHENYL ESTER; 2,2 DIMETHYLPROPIONIC ACID 4 (2' OXO BUTYL)PHENYL ESTER; 2,2 DIMETHYLPROPIONIC ACID 4 [2 ETHYL 3 (4 HYDROXYPHENYL) 3 [4 (2 PYRROLIDIN 1 YL ETHOXY)PHENYL]ALLYL]PHENYL ESTER; 4 (1,2 DIPHENYL 1 BUTENYL)CINNAMIC ACID; 4 [1 [4 (2 DIMETHYLAMINOETHOXY)PHENYL] 2 (4 HYDROXYBENZYL)BUT 1 ENYL]PHENOL; 4 [2 (2 HYDROXYBENZYL) 1 [4 (2 PYRROLIDIN 1 YLETHOXY)PHENYL]BUT 1 ENYL]PHENOL; 4 [2 (3 HYDROXYBENZYL) 1 [4 (2 PYRROLIDIN 1 YLETHOXY)PHENYL]BUT 1 ENYL]PHENOL; 4 [2 (4 HYDROXYBENZYL) 1 [4 ( 2 MORPHOLIN 4 YLETHOXY)PHENYL]BUT 1 ENYL]PHENOL; 4 [2 (4 HYDROXYBENZYL) 1 [4 (2 PIPERIDIN 1 YLETHOXY)PHENYL]BUT 1 ENYL]PHENOL; 4 [2 (4 HYDROXYBENZYL) 1 [4 (2 PYRROLIDIN 1 YLETHOXY)PHENYL]BUT 1 ENYL]PHENOL; 4 HYDROXYTAMOXIFEN; ACETIC ACID 4 [3 (4 ACETOXYPHENYL) 2 ETHYL 3 [4 (2 PYRROLIDIN 1 YLETHOXY)PHENYL]ALLYL]PHENYL ESTER; ANTINEOPLASTIC AGENT; BENZOXEPIN DERIVATIVE; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FERROCENE DERIVATIVE; FURAN DERIVATIVE; IC 164384; ISOQUINOLINE DERIVATIVE; NANOPARTICLE; NAPHTHALENE DERIVATIVE; QUINOLINE DERIVATIVE; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

APOPTOSIS; ARTICLE; BINDING AFFINITY; BREAST CANCER; CANCER CELL; COMPUTER ANALYSIS; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; FLOW CYTOMETRY; HUMAN; MOLECULAR MODEL; PREDICTION; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

ANTINEOPLASTIC AGENTS; BINDING SITES; BREAST NEOPLASMS; CELL PROLIFERATION; CELLS, CULTURED; ESTROGEN ANTAGONISTS; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; MODELS, MOLECULAR; RALOXIFENE; RECEPTORS, ESTROGEN; STRUCTURE-ACTIVITY RELATIONSHIP; STYRENES; TAMOXIFEN;

EID: 33746123007     PISSN: 15734064     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340606776056142     Document Type: Article

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