De novo design, synthesis and evaluation of a non-steroidal diphenylnaphthyl propylene ligand for the estrogen receptor

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 7, 2003, Pages 1389-1396

  Schmidt, Jonathan M ^a   Mercure, Julie ^a,b   Tremblay, Gilles B ^a   Pagé, Martine ^a   Feher, Miklos ^a   Dunn Dufault, Robert ^a   Peter, Markus G ^a   Redden, Peter R ^a  

^a Signalgene Inc Canada   (Canada)

^b SYNX Pharma Inc   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 HYDROXYPHENYL) 2 [4 [2 (1 PYRROLIDINYL)ETHOXY]PHENYL] 1 (6 HYDROXYNAPHTHALEN 1 YL)PROPENE; 1 (4 METHOXYPHENYL) 2 [4 (2 CHLOROETHOXY)PHENYL] 1 PROPANONE; 1 IODO 6 METHOXYNAPHTHALENE; 4 [4 METHYL 2 [4 [2 (1 PIPERIDINYL)ETHOXY]PHENYL] 7 PIVALOYLOXY 2H 1 BENZOPYRAN 3 YLPHENYL] PIVALATE; BAZEDOXIFENE; DEHYDRORETINOL; ESTRADIOL; ESTROGEN RECEPTOR; FUNCTIONAL GROUP; HALOGEN; HYDROXYL GROUP; KETONE DERIVATIVE; LASOFOXIFENE; NAFOXIDINE; NAPHTHALENE DERIVATIVE; PROTEIN PS2; PYRROLIDINE DERIVATIVE; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TAMOXIFEN; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; GENETIC TRANSFECTION; HORMONE INHIBITION; NONHUMAN; PROMOTER REGION; RECEPTOR DOWN REGULATION; STRUCTURE ACTIVITY RELATION;

EID: 0037375656     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00647-8     Document Type: Article

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