[(S)-(+)-4-[7-(2,2-Dimethyl-1-oxopropoxy)-4-methyl-2-[4-[2-(1- piperidinyl)-ethoxy]phenyl]-2h-1-benzopyran-3-yl]-phenyl 2,2- Dimethylpropanoate (EM-800): A highly potent, specific, and orally active nonsteroidal antiestrogen

Journal of Medicinal Chemistry

Volumn 40, Issue 14, 1997, Pages 2117-2122

  Gauthier, S ^a   Caron, B ^a   Cloutier, J ^a   Dory, Y L ^a   Favre, A ^a   Larouche, D ^a   Mailhot, J ^a   Ouellet, C ^a   Schwerdtfeger, A ^a   Leblanc, G ^a   Martel, C ^a   Simard, J ^a   Merand, Y ^a   Belanger, A ^a   Labrie, C ^a   Labrie, F ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4 HYDROXYPHENYL) 2 [4 [2 (1 PIPERIDINYL)ETHOXY]PHENYL] 2H 1 BENZOPYRAN 7 OL; 4 [4 METHYL 2 [4 [2 (1 PIPERIDINYL)ETHOXY]PHENYL] 7 PIVALOYLOXY 2H 1 BENZOPYRAN 3 YLPHENYL] PIVALATE; 4 HYDROXYTAMOXIFEN; ACOLBIFENE; ALKALINE PHOSPHATASE; ANTIESTROGEN; DIETHYLSTILBESTROL; ESTRADIOL; ESTROGEN RECEPTOR; ESTRONE; FULVESTRANT; N BUTYL 11 (3,17BETA DIHYDROXYESTRA 1,3,5(10) TRIEN 7ALPHA YL) N METHYLUNDECANAMIDE; RALOXIFENE; TAMOXIFEN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BREAST CANCER; CANCER CELL CULTURE; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; ENDOMETRIUM CARCINOMA; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NOTE; ORAL DRUG ADMINISTRATION; OVARIECTOMY; RECEPTOR AFFINITY; SUBCUTANEOUS DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; ANIMALS; BENZOPYRANS; BINDING, COMPETITIVE; BREAST NEOPLASMS; CYTOSOL; DIETHYLSTILBESTROL; ESTRADIOL; ESTROGEN ANTAGONISTS; FEMALE; HUMANS; MICE; MOLECULAR STRUCTURE; OVARIECTOMY; PIPERIDINES; PROPIONATES; RALOXIFENE; RECEPTORS, ESTROGEN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; UTERUS;

EID: 0030793285     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970095o     Document Type: Note

References (20)