Installation of the pyrrolyl-2-carboxyl pharmacophore by CouN1 and CouN7 in the late biosynthetic steps of the aminocoumarin antibiotics clorobiocin and coumermycin A1

Biochemistry

Volumn 45, Issue 28, 2006, Pages 8568-8578

  Garneau Tsodikova, Sylvie ^a,c   Stapon, Anthony ^b   Kahne, Daniel ^b   Walsh, Christopher T ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD UNIVERSITY   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; BINDING ENERGY; BIOSYNTHESIS; DERIVATIVES; DNA; ENZYME INHIBITION; SUBSTRATES;

5-METHYL-2-PYRROLYLCARBONYL MOIETY; AMINOCOUMARIN ANTIBIOTICS CLOROBIOCIN; PHOSPHOPANTETHEINYL TRANSFERASE; TYPE-II TOPOISOMERASE DNA GYRASE;

CHROMOPHORES;

ACYLTRANSFERASE; ADENOSINE TRIPHOSPHATE; ANTIBIOTIC AGENT; CARBOXYL GROUP; CLOROBIOCIN; COUMAMYCIN A1; COUMARIN DERIVATIVE; DECARBAMOYLNOVOBIOCIN; DNA TOPOISOMERASE (ATP HYDROLYSING); HYDROXYL GROUP; NOVOBIOCIN; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; BINDING SITE; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; ESCHERICHIA COLI; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ACYLTRANSFERASES; ADENOSINE MONOPHOSPHATE; AMINOCOUMARINS; ANTIBIOTICS, ANTINEOPLASTIC; CATALYSIS; CLONING, MOLECULAR; ESCHERICHIA COLI; GENES, FUNGAL; KINETICS; NOVOBIOCIN; RECOMBINANT PROTEINS; STREPTOMYCES;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 33746061680     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi060784e     Document Type: Article

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