메뉴 건너뛰기




Volumn 27, Issue 8, 2006, Pages 1919-1925

Processing of cocaine- and amphetamine-regulated transcript (CART) precursor proteins by prohormone convertases (PCs) and its implications

Author keywords

CART (Cocaine and amphetamine regulated transcript); PC (Prohormone proprotein convertase); Peptide precursor processing; Post translational modification

Indexed keywords

CALCIUM; COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PEPTIDE; FURIN; ISOPROTEIN; PROPROTEIN CONVERTASE 1; PROPROTEIN CONVERTASE 2; PROPROTEIN CONVERTASE 5; PROTEIN PRECURSOR;

EID: 33746015049     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2005.10.028     Document Type: Review
Times cited : (20)

References (76)
  • 2
    • 0033303819 scopus 로고    scopus 로고
    • Distinct physiologic and neuronal responses to decreased leptin and mild hyperleptinemia
    • Ahima R.S., Kelly J., Elmquist J.K., and Flier J.S. Distinct physiologic and neuronal responses to decreased leptin and mild hyperleptinemia. Endocrinology 140 (1999) 4923-4931
    • (1999) Endocrinology , vol.140 , pp. 4923-4931
    • Ahima, R.S.1    Kelly, J.2    Elmquist, J.K.3    Flier, J.S.4
  • 3
    • 0034802121 scopus 로고    scopus 로고
    • Absence of cocaine- and amphetamine-regulated transcript results in obesity in mice fed a high caloric diet
    • Ascinar M.A., Smith D.P., Yang D.D., Heiman M.L., Fox N., Chen Y., et al. Absence of cocaine- and amphetamine-regulated transcript results in obesity in mice fed a high caloric diet. Endocrinology 142 (2001) 4394-4400
    • (2001) Endocrinology , vol.142 , pp. 4394-4400
    • Ascinar, M.A.1    Smith, D.P.2    Yang, D.D.3    Heiman, M.L.4    Fox, N.5    Chen, Y.6
  • 4
    • 0032566775 scopus 로고    scopus 로고
    • PC5-A-mediated processing of pro-neurotensin in early compartments of the regulated secretory pathway of PC5-transfected PC12 cells
    • Barbero P., Rovere C., De Bie I., Seidah N.G., Beaudet A., and Kitabgi P. PC5-A-mediated processing of pro-neurotensin in early compartments of the regulated secretory pathway of PC5-transfected PC12 cells. J Biol Chem 273 (1998) 25339-25346
    • (1998) J Biol Chem , vol.273 , pp. 25339-25346
    • Barbero, P.1    Rovere, C.2    De Bie, I.3    Seidah, N.G.4    Beaudet, A.5    Kitabgi, P.6
  • 5
    • 0036325531 scopus 로고    scopus 로고
    • Genetic approaches to studying energy balance: perception and integration
    • Barsh G.S., and Schwartz M.W. Genetic approaches to studying energy balance: perception and integration. Nat Rev Genet 3 (2002) 589-600
    • (2002) Nat Rev Genet , vol.3 , pp. 589-600
    • Barsh, G.S.1    Schwartz, M.W.2
  • 6
    • 0027765503 scopus 로고
    • Differential processing of proenkephalin by prohormone convertases 1(3) and 2 and furin
    • Breslin M.B., Lindberg I., Benjannet S., Mathis J.P., Lazure C., and Seidah N.G. Differential processing of proenkephalin by prohormone convertases 1(3) and 2 and furin. J Biol Chem 268 (1993) 27084-27093
    • (1993) J Biol Chem , vol.268 , pp. 27084-27093
    • Breslin, M.B.1    Lindberg, I.2    Benjannet, S.3    Mathis, J.P.4    Lazure, C.5    Seidah, N.G.6
  • 7
    • 0034895531 scopus 로고    scopus 로고
    • Neuronal cell lines expressing PC5, but not PC1 or PC2, process pro-CCK into glycine-extended CCK 12 and 22
    • Cain B.M., Vishnuvardhan D., and Beinfeld M.C. Neuronal cell lines expressing PC5, but not PC1 or PC2, process pro-CCK into glycine-extended CCK 12 and 22. Peptides 22 (2001) 1271-1277
    • (2001) Peptides , vol.22 , pp. 1271-1277
    • Cain, B.M.1    Vishnuvardhan, D.2    Beinfeld, M.C.3
  • 8
    • 77956712498 scopus 로고    scopus 로고
    • The enzymology of PC1 and PC2
    • Dalbey R.E., and Sigman D.S. (Eds), Academic Press, New York
    • Cameron A., Apletalina E.V., and Lindberg I. The enzymology of PC1 and PC2. In: Dalbey R.E., and Sigman D.S. (Eds). The enzymes. 3rd ed. (2002), Academic Press, New York 291-328
    • (2002) The enzymes. 3rd ed. , pp. 291-328
    • Cameron, A.1    Apletalina, E.V.2    Lindberg, I.3
  • 9
    • 0034194471 scopus 로고    scopus 로고
    • SPC4/PACE4 regulates a TGF-beta signaling network during axis formation
    • Constam D.B., and Robertson E.J. SPC4/PACE4 regulates a TGF-beta signaling network during axis formation. Genes Dev 14 (2000) 1146-1155
    • (2000) Genes Dev , vol.14 , pp. 1146-1155
    • Constam, D.B.1    Robertson, E.J.2
  • 10
    • 0033952923 scopus 로고    scopus 로고
    • Tissue-specific requirements for the proprotein convertase furin/SPC1 during embryonic turning and heart looping
    • Constam D.B., and Robertson E.J. Tissue-specific requirements for the proprotein convertase furin/SPC1 during embryonic turning and heart looping. Development 127 (2000) 245-254
    • (2000) Development , vol.127 , pp. 245-254
    • Constam, D.B.1    Robertson, E.J.2
  • 11
    • 0000067107 scopus 로고    scopus 로고
    • Genetics and pathophysiology of human obesity
    • Cummings D.E., and Schwartz M.W. Genetics and pathophysiology of human obesity. Annu Rev Med 54 (2003) 453-471
    • (2003) Annu Rev Med , vol.54 , pp. 453-471
    • Cummings, D.E.1    Schwartz, M.W.2
  • 12
    • 0030443840 scopus 로고    scopus 로고
    • The isoforms of proprotein convertase PC5 are sorted to different subcellular compartments
    • De Bie I., Marcinkiewicz M., Malide D., Lazure C., Nakayama K., Bendayan M., et al. The isoforms of proprotein convertase PC5 are sorted to different subcellular compartments. J Cell Biol 135 (1996) 1261-1275
    • (1996) J Cell Biol , vol.135 , pp. 1261-1275
    • De Bie, I.1    Marcinkiewicz, M.2    Malide, D.3    Lazure, C.4    Nakayama, K.5    Bendayan, M.6
  • 13
    • 0035462630 scopus 로고    scopus 로고
    • Mutational screening of the CART gene in obese children: identifying a mutation (Leu34 Phe) associated with reduced resting energy expenditure and cosegregating with obesity phenotype in a large family
    • del Giudice E.M., Santoro N., Cirillo G., D'Urso L., Toro R.D., and Perrone L. Mutational screening of the CART gene in obese children: identifying a mutation (Leu34 Phe) associated with reduced resting energy expenditure and cosegregating with obesity phenotype in a large family. Diabetes 50 (2001) 2157-2160
    • (2001) Diabetes , vol.50 , pp. 2157-2160
    • del Giudice, E.M.1    Santoro, N.2    Cirillo, G.3    D'Urso, L.4    Toro, R.D.5    Perrone, L.6
  • 14
    • 12344302029 scopus 로고    scopus 로고
    • Significance of prohormone convertase 2, PC2, mediated initial cleavage at the proglucagon intermediate site, Lys70-Arg71, to generate glucagon
    • Dey A., Lipkind G.M., Rouille Y., Norrbom C., Stein J., Zhang C., et al. Significance of prohormone convertase 2, PC2, mediated initial cleavage at the proglucagon intermediate site, Lys70-Arg71, to generate glucagon. Endocrinology 146 (2005) 713-727
    • (2005) Endocrinology , vol.146 , pp. 713-727
    • Dey, A.1    Lipkind, G.M.2    Rouille, Y.3    Norrbom, C.4    Stein, J.5    Zhang, C.6
  • 15
    • 1642423625 scopus 로고    scopus 로고
    • Furin and prohormone convertase 1/3 are major convertases in the processing of mouse pro-growth hormone-releasing hormone
    • Dey A., Norrbom C., Zhu X., Stein J., Zhang C., Ueda K., et al. Furin and prohormone convertase 1/3 are major convertases in the processing of mouse pro-growth hormone-releasing hormone. Endocrinology 145 (2004) 1961-1971
    • (2004) Endocrinology , vol.145 , pp. 1961-1971
    • Dey, A.1    Norrbom, C.2    Zhu, X.3    Stein, J.4    Zhang, C.5    Ueda, K.6
  • 16
    • 0038013621 scopus 로고    scopus 로고
    • Biological processing of the cocaine- and amphetamine-regulated transcript precursors by prohormone convertases, PC2 and PC1/3
    • Dey A., Zhu X., Carroll R., Turck C.W., Stein J., and Steiner D.F. Biological processing of the cocaine- and amphetamine-regulated transcript precursors by prohormone convertases, PC2 and PC1/3. J Biol Chem 278 (2003) 15007-15014
    • (2003) J Biol Chem , vol.278 , pp. 15007-15014
    • Dey, A.1    Zhu, X.2    Carroll, R.3    Turck, C.W.4    Stein, J.5    Steiner, D.F.6
  • 17
    • 0036142591 scopus 로고    scopus 로고
    • Gene expression of proprotein convertases in individual rat anterior pituitary cells and their regulation in corticotrophs mediated by glucocorticoids
    • Dong W., and Day R. Gene expression of proprotein convertases in individual rat anterior pituitary cells and their regulation in corticotrophs mediated by glucocorticoids. Endocrinology 143 (2002) 254-262
    • (2002) Endocrinology , vol.143 , pp. 254-262
    • Dong, W.1    Day, R.2
  • 18
    • 0028943539 scopus 로고
    • Distinct mRNA expression of highly homologous convertases PC5 and PACE4 in rat brain and pituitary
    • Dong W., Marcinkiewicz M., Vieau D., Chretien M., Siedah N., and Day R. Distinct mRNA expression of highly homologous convertases PC5 and PACE4 in rat brain and pituitary. J Neurosci 15 (1995) 1778-1796
    • (1995) J Neurosci , vol.15 , pp. 1778-1796
    • Dong, W.1    Marcinkiewicz, M.2    Vieau, D.3    Chretien, M.4    Siedah, N.5    Day, R.6
  • 19
    • 0029879270 scopus 로고    scopus 로고
    • Characterization of the human cDNA and genomic DNA encoding CART: a cocaine- and amphetamine-regulated transcript
    • [2]
    • Douglass J., and Daoud S. Characterization of the human cDNA and genomic DNA encoding CART: a cocaine- and amphetamine-regulated transcript. Gene 169 (1996) 241-245 [2]
    • (1996) Gene , vol.169 , pp. 241-245
    • Douglass, J.1    Daoud, S.2
  • 20
    • 0028947053 scopus 로고
    • PCR differential display identifies a rat brain mRNA that is transcriptionally regulated by cocaine and amphetamine
    • Douglass J., McKinzie A.A., and Couceyro P. PCR differential display identifies a rat brain mRNA that is transcriptionally regulated by cocaine and amphetamine. J Neurosci 15 (1995) 2471-2481
    • (1995) J Neurosci , vol.15 , pp. 2471-2481
    • Douglass, J.1    McKinzie, A.A.2    Couceyro, P.3
  • 21
    • 0037686295 scopus 로고    scopus 로고
    • Killing the messenger: short RNAs that silence gene expression
    • Dykxhoorn D.M., Novina C.D., and Sharp P.A. Killing the messenger: short RNAs that silence gene expression. Nat Rev Mol Cell Biol 4 (2003) 457-467
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 457-467
    • Dykxhoorn, D.M.1    Novina, C.D.2    Sharp, P.A.3
  • 22
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir S.M., Harborth J., Lendeckel W., Yalcin A., Weber K., and Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411 (2001) 494-498
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 23
    • 0032436307 scopus 로고    scopus 로고
    • Leptin activates hypothalamic CART neurons projecting to the spinal cord
    • Elias C.F., Lee C., Kelly J., Aschkenasi C., Ahima R.S., Couceyro P.R., et al. Leptin activates hypothalamic CART neurons projecting to the spinal cord. Neuron 21 (1998) 1375-1385
    • (1998) Neuron , vol.21 , pp. 1375-1385
    • Elias, C.F.1    Lee, C.2    Kelly, J.3    Aschkenasi, C.4    Ahima, R.S.5    Couceyro, P.R.6
  • 25
    • 0035710726 scopus 로고    scopus 로고
    • Hypothalamic pathways underlying the endocrine, autonomic, and behavioral effects of leptin
    • Elmquist J.K. Hypothalamic pathways underlying the endocrine, autonomic, and behavioral effects of leptin. Int J Obes Relat Metab Disord Suppl 5 (2001) S78-S82
    • (2001) Int J Obes Relat Metab Disord , Issue.SUPPL. 5
    • Elmquist, J.K.1
  • 26
    • 33645237960 scopus 로고    scopus 로고
    • Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse
    • Essalmani R., Hamelin J., Marcinkiewicz J., Chamberland A., Mbikay M., Chretien M., et al. Deletion of the gene encoding proprotein convertase 5/6 causes early embryonic lethality in the mouse. Mol Cell Biol 26 (2006) 354-361
    • (2006) Mol Cell Biol , vol.26 , pp. 354-361
    • Essalmani, R.1    Hamelin, J.2    Marcinkiewicz, J.3    Chamberland, A.4    Mbikay, M.5    Chretien, M.6
  • 27
    • 0032488981 scopus 로고    scopus 로고
    • Incomplete processing of proinsulin to insulin accompanied by elevation of des-31, 32 proinsulin intermediate in islets of mice lacking active PC2
    • Furuta M., Carroll R., Martin S., Swift H.H., Ravazzola M., Orci L., et al. Incomplete processing of proinsulin to insulin accompanied by elevation of des-31, 32 proinsulin intermediate in islets of mice lacking active PC2. J Biol Chem 273 (1998) 3431-3437
    • (1998) J Biol Chem , vol.273 , pp. 3431-3437
    • Furuta, M.1    Carroll, R.2    Martin, S.3    Swift, H.H.4    Ravazzola, M.5    Orci, L.6
  • 28
    • 12644253798 scopus 로고    scopus 로고
    • Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2
    • Furuta M., Yano H., Zhou A., Rouille Y., Holst J.J., Carroll R., et al. Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2. Proc Natl Acad Sci USA 94 (1997) 6646-6651
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 6646-6651
    • Furuta, M.1    Yano, H.2    Zhou, A.3    Rouille, Y.4    Holst, J.J.5    Carroll, R.6
  • 29
    • 0029020219 scopus 로고
    • Direct role of furin in mammalian prosomatostatin processing
    • Galanopoulou A.S., Seidah N.G., and Patel Y.C. Direct role of furin in mammalian prosomatostatin processing. Biochem J 309 (1995) 33-40
    • (1995) Biochem J , vol.309 , pp. 33-40
    • Galanopoulou, A.S.1    Seidah, N.G.2    Patel, Y.C.3
  • 30
    • 0037062951 scopus 로고    scopus 로고
    • RNA interference
    • Hannon G.J. RNA interference. Nature 418 (2002) 244-251
    • (2002) Nature , vol.418 , pp. 244-251
    • Hannon, G.J.1
  • 31
    • 0028911715 scopus 로고
    • Proparathyroid hormone is preferentially cleaved to parathyroid hormone by the prohormone convertase furin
    • Hendy G.N., Bennett H.P.J., Gibbs B.F., Lazure C., Day R., and Seidah N.G. Proparathyroid hormone is preferentially cleaved to parathyroid hormone by the prohormone convertase furin. J Biol Chem 270 (1995) 9517-9525
    • (1995) J Biol Chem , vol.270 , pp. 9517-9525
    • Hendy, G.N.1    Bennett, H.P.J.2    Gibbs, B.F.3    Lazure, C.4    Day, R.5    Seidah, N.G.6
  • 32
    • 0037743535 scopus 로고    scopus 로고
    • The crystal structure of the proprotein processing proteinase furin explains its stringent specificity
    • Henrich S., Cameron A., Bourenkov G.P., Kiefersauer R., Huber R., Lindberg I., et al. The crystal structure of the proprotein processing proteinase furin explains its stringent specificity. Nat Struc Biol 10 (2003) 520-526
    • (2003) Nat Struc Biol , vol.10 , pp. 520-526
    • Henrich, S.1    Cameron, A.2    Bourenkov, G.P.3    Kiefersauer, R.4    Huber, R.5    Lindberg, I.6
  • 35
    • 0029008482 scopus 로고
    • Age-related alterations in the expression of prohormone convertase messenger ribonucleic acid (mRNA) levels in hypothalamic proopiomelanocortin mRNA neurons in the female C57BL/6J mouse
    • Joshi D., Miller M.M., Seidah N.G., and Day R. Age-related alterations in the expression of prohormone convertase messenger ribonucleic acid (mRNA) levels in hypothalamic proopiomelanocortin mRNA neurons in the female C57BL/6J mouse. Endocrinology 136 (1995) 2721-2729
    • (1995) Endocrinology , vol.136 , pp. 2721-2729
    • Joshi, D.1    Miller, M.M.2    Seidah, N.G.3    Day, R.4
  • 36
    • 0021713896 scopus 로고
    • Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-α-factor
    • Julius D., Brake A., Blair L., Kunisawa R., and Thorner J. Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-α-factor. Cell 37 (1984) 1075-1089
    • (1984) Cell , vol.37 , pp. 1075-1089
    • Julius, D.1    Brake, A.2    Blair, L.3    Kunisawa, R.4    Thorner, J.5
  • 37
    • 0028818924 scopus 로고
    • PC1/3, and/or PC5/6A process rabbit, but not human, pro-lactase-phlorizin hydrolase to the 180-kDa intermediate
    • Keller P., Zecca L., Boukamel R., Zwicker E., Gloor S., and Furin S.G. PC1/3, and/or PC5/6A process rabbit, but not human, pro-lactase-phlorizin hydrolase to the 180-kDa intermediate. J Biol Chem 270 (1995) 25722-25728
    • (1995) J Biol Chem , vol.270 , pp. 25722-25728
    • Keller, P.1    Zecca, L.2    Boukamel, R.3    Zwicker, E.4    Gloor, S.5    Furin, S.G.6
  • 38
    • 0036083664 scopus 로고    scopus 로고
    • Proprotein convertases in tumor progression and malignancy. Novel targets in cancer therapy
    • Khatib A.M., Siegfried G., Chretien M., Metrakos P., and Seidah N.G. Proprotein convertases in tumor progression and malignancy. Novel targets in cancer therapy. Am J Pathol 160 (2002) 1921-1935
    • (2002) Am J Pathol , vol.160 , pp. 1921-1935
    • Khatib, A.M.1    Siegfried, G.2    Chretien, M.3    Metrakos, P.4    Seidah, N.G.5
  • 40
    • 0033198026 scopus 로고    scopus 로고
    • CART peptide analysis by western blotting
    • Kuhar M.J., and Yoho L.L. CART peptide analysis by western blotting. Synapse 33 (1999) 163-171
    • (1999) Synapse , vol.33 , pp. 163-171
    • Kuhar, M.J.1    Yoho, L.L.2
  • 41
    • 20444458591 scopus 로고    scopus 로고
    • Cocaine- and amphetamine-regulated transcript (CART) peptide activates the extracellular signal-regulated kinase (ERK) pathway in AtT20 cells via putative G-protein coupled receptors
    • Lakatos A., Prinster S., Vicentic A., Hall R.A., and Kuhar M.J. Cocaine- and amphetamine-regulated transcript (CART) peptide activates the extracellular signal-regulated kinase (ERK) pathway in AtT20 cells via putative G-protein coupled receptors. Neurosci Lett 384 (2005) 198-202
    • (2005) Neurosci Lett , vol.384 , pp. 198-202
    • Lakatos, A.1    Prinster, S.2    Vicentic, A.3    Hall, R.A.4    Kuhar, M.J.5
  • 43
    • 0842313106 scopus 로고    scopus 로고
    • Biosynthesis of proopiomelanocortin-derived peptides in prohormone convertase 2 and 7B2 null mice
    • Laurent V., Jaubert-Miazza L., Desjardins R., Day R., and Lindberg I. Biosynthesis of proopiomelanocortin-derived peptides in prohormone convertase 2 and 7B2 null mice. Endocrinology 145 (2004) 519-528
    • (2004) Endocrinology , vol.145 , pp. 519-528
    • Laurent, V.1    Jaubert-Miazza, L.2    Desjardins, R.3    Day, R.4    Lindberg, I.5
  • 44
    • 0035822626 scopus 로고    scopus 로고
    • Solution structure of the satiety factor, CART, reveals new functionality of a well-known fold
    • Ludvigsen S., Thim L., Blom A.M., and Wulff B.S. Solution structure of the satiety factor, CART, reveals new functionality of a well-known fold. Biochemistry 40 (2001) 9082-9088
    • (2001) Biochemistry , vol.40 , pp. 9082-9088
    • Ludvigsen, S.1    Thim, L.2    Blom, A.M.3    Wulff, B.S.4
  • 47
    • 0034465866 scopus 로고    scopus 로고
    • Cocaine-amphetamine-regulated transcript (CART) acts in the central nervous system to inhibit gastric acid secretion via brain corticotropin-releasing factor system
    • Okumura T., Yamada H., Motomura W., and Kohgo Y. Cocaine-amphetamine-regulated transcript (CART) acts in the central nervous system to inhibit gastric acid secretion via brain corticotropin-releasing factor system. Endocrinology 141 (2000) 2854-2860
    • (2000) Endocrinology , vol.141 , pp. 2854-2860
    • Okumura, T.1    Yamada, H.2    Motomura, W.3    Kohgo, Y.4
  • 48
    • 15444366205 scopus 로고    scopus 로고
    • Neuropeptide processing profile in mice lacking prohormone convertase-1
    • Pan H., Nanno D., Che F.Y., Zhu X., Salton S.R., Steiner D.F., et al. Neuropeptide processing profile in mice lacking prohormone convertase-1. Biochemistry 44 (2005) 4939-4948
    • (2005) Biochemistry , vol.44 , pp. 4939-4948
    • Pan, H.1    Nanno, D.2    Che, F.Y.3    Zhu, X.4    Salton, S.R.5    Steiner, D.F.6
  • 49
    • 0027989934 scopus 로고
    • The neuroendocrine precursor 7B2 is a sulfated protein proteolytically processed by a ubiquitous furin-like convertase
    • Paquet L., Bergeron F., Boudreault A., Seidah N.G., Chretien M., Mbikay M., et al. The neuroendocrine precursor 7B2 is a sulfated protein proteolytically processed by a ubiquitous furin-like convertase. J Biol Chem 269 (1994) 19279-19285
    • (1994) J Biol Chem , vol.269 , pp. 19279-19285
    • Paquet, L.1    Bergeron, F.2    Boudreault, A.3    Seidah, N.G.4    Chretien, M.5    Mbikay, M.6
  • 50
    • 0029914570 scopus 로고    scopus 로고
    • Proneuropeptide Y processing in large dense-core vesicles: manipulation of prohormone convertase expression in sympathetic neurons using adenoviruses
    • Paquet L., Massie B., and Mains R.E. Proneuropeptide Y processing in large dense-core vesicles: manipulation of prohormone convertase expression in sympathetic neurons using adenoviruses. J Neurosci 16 (1996) 964-973
    • (1996) J Neurosci , vol.16 , pp. 964-973
    • Paquet, L.1    Massie, B.2    Mains, R.E.3
  • 51
    • 4243162178 scopus 로고    scopus 로고
    • Stepwise posttranslational processing of progrowth hormone-releasing hormone polypeptide by furin and PC1
    • Posner S.F., Vaslet C.A., Jurofcik M., Lee A., Seidah N.G., and Nillni E. Stepwise posttranslational processing of progrowth hormone-releasing hormone polypeptide by furin and PC1. Endocrine 23 (2004) 199-213
    • (2004) Endocrine , vol.23 , pp. 199-213
    • Posner, S.F.1    Vaslet, C.A.2    Jurofcik, M.3    Lee, A.4    Seidah, N.G.5    Nillni, E.6
  • 52
    • 0442292293 scopus 로고    scopus 로고
    • The kindest cuts of all: crystal structures of Kex2 and furin reveal secrets of precursor processing
    • Rockwell N.C., and Thorner J.W. The kindest cuts of all: crystal structures of Kex2 and furin reveal secrets of precursor processing. Trends Biochem Sci 29 (2004) 80-87
    • (2004) Trends Biochem Sci , vol.29 , pp. 80-87
    • Rockwell, N.C.1    Thorner, J.W.2
  • 53
    • 0032443652 scopus 로고    scopus 로고
    • Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase furin
    • Roebroek A.J., Umans L., Pauli I.G., Robertson E.J., van Leuven F., Van de Ven W.J., et al. Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase furin. Development 125 (1998) 4863-4876
    • (1998) Development , vol.125 , pp. 4863-4876
    • Roebroek, A.J.1    Umans, L.2    Pauli, I.G.3    Robertson, E.J.4    van Leuven, F.5    Van de Ven, W.J.6
  • 54
    • 0030806930 scopus 로고    scopus 로고
    • Processing of prothyrotropin-releasing hormone by the family of prohormone convertases
    • Schaner P., Todd R.B., Seidah N.G., and Nillni E.A. Processing of prothyrotropin-releasing hormone by the family of prohormone convertases. J Biol Chem 272 (1997) 19958-19968
    • (1997) J Biol Chem , vol.272 , pp. 19958-19968
    • Schaner, P.1    Todd, R.B.2    Seidah, N.G.3    Nillni, E.A.4
  • 55
    • 0033452452 scopus 로고    scopus 로고
    • Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides
    • Seidah N.G., and Chretien M. Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides. Brain Res 848 (1999) 45-62
    • (1999) Brain Res , vol.848 , pp. 45-62
    • Seidah, N.G.1    Chretien, M.2
  • 56
    • 0027965348 scopus 로고
    • The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions
    • Seidah N.G., Chretien M., and Day R. The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions. Biochimie 76 (1994) 197-209
    • (1994) Biochimie , vol.76 , pp. 197-209
    • Seidah, N.G.1    Chretien, M.2    Day, R.3
  • 57
    • 0025284946 scopus 로고
    • cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for prohormone processing proteinases
    • Seidah N.G., Gaspar L., Mion P., Marcinkiewicz M., Mbikay M., and Chretien M. cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for prohormone processing proteinases. DNA Cell Biol 9 (1990) 415-424
    • (1990) DNA Cell Biol , vol.9 , pp. 415-424
    • Seidah, N.G.1    Gaspar, L.2    Mion, P.3    Marcinkiewicz, M.4    Mbikay, M.5    Chretien, M.6
  • 58
    • 0025803098 scopus 로고
    • Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2
    • Seidah N.G., Marcinkiewicz M., Benjannet S., Gaspar L., Beaubien G., Mattei M.G., et al. Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2. Mol Endocrinol 5 (1991) 111-122
    • (1991) Mol Endocrinol , vol.5 , pp. 111-122
    • Seidah, N.G.1    Marcinkiewicz, M.2    Benjannet, S.3    Gaspar, L.4    Beaubien, G.5    Mattei, M.G.6
  • 59
    • 0025214491 scopus 로고
    • Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2
    • Smeekens S.P., and Steiner D.F. Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2. J Biol Chem 265 (1990) 2997-3000
    • (1990) J Biol Chem , vol.265 , pp. 2997-3000
    • Smeekens, S.P.1    Steiner, D.F.2
  • 60
    • 0026088633 scopus 로고
    • Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans
    • Smeekens S.P., Avruch A.S., LaMendola J., Chan S.J., and Steiner D.F. Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans. Proc Natl Acad Sci USA 88 (1991) 340-344
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 340-344
    • Smeekens, S.P.1    Avruch, A.S.2    LaMendola, J.3    Chan, S.J.4    Steiner, D.F.5
  • 61
    • 33746016605 scopus 로고    scopus 로고
    • Stein J, et al. (unpublished data).
  • 62
    • 77956664692 scopus 로고    scopus 로고
    • The prohormone convertases and precursor processing in protein biosynthesis
    • Dalbey R.E., and Sigman D.S. (Eds), Academic Press, New York
    • Steiner D.F. The prohormone convertases and precursor processing in protein biosynthesis. In: Dalbey R.E., and Sigman D.S. (Eds). The enzymes. 3rd ed. (2002), Academic Press, New York 163-198
    • (2002) The enzymes. 3rd ed. , pp. 163-198
    • Steiner, D.F.1
  • 63
    • 0000962628 scopus 로고
    • The biosynthesis of insulin and a probable precursor of insulin by a human islet cell adenoma
    • Steiner D.F., and Oyer P.E. The biosynthesis of insulin and a probable precursor of insulin by a human islet cell adenoma. Proc Natl Acad Sci USA 57 (1967) 473-480
    • (1967) Proc Natl Acad Sci USA , vol.57 , pp. 473-480
    • Steiner, D.F.1    Oyer, P.E.2
  • 64
  • 65
    • 0038461962 scopus 로고    scopus 로고
    • Curbing activation: proprotein convertases in homeostasis and pathology
    • Taylor N.A., Van de Ven W.J.M., and Creemers J.W.M. Curbing activation: proprotein convertases in homeostasis and pathology. FASEB J 17 (2003) 1215-1227
    • (2003) FASEB J , vol.17 , pp. 1215-1227
    • Taylor, N.A.1    Van de Ven, W.J.M.2    Creemers, J.W.M.3
  • 66
    • 0033046967 scopus 로고    scopus 로고
    • Tissue-specific processing of cocaine- and amphetamine- regulated transcript peptides in the rat
    • Thim L., Kristensen P., Nielsen P.F., Wulff B.S., and Clausen J.T. Tissue-specific processing of cocaine- and amphetamine- regulated transcript peptides in the rat. Proc Natl Acad Sci USA 96 (1999) 2722-2727
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 2722-2727
    • Thim, L.1    Kristensen, P.2    Nielsen, P.F.3    Wulff, B.S.4    Clausen, J.T.5
  • 67
    • 0036791359 scopus 로고    scopus 로고
    • Furin at the cutting edge: from protein traffic to embryogenesis and disease
    • Thomas G. Furin at the cutting edge: from protein traffic to embryogenesis and disease. Nat Rev Mol Cell Biol 3 (2002) 753-766
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 753-766
    • Thomas, G.1
  • 68
    • 1442274636 scopus 로고    scopus 로고
    • Impaired intestinal proglucagon processing in mice lacking prohormone convertase 1
    • Ugleholdt R., Zhu X., Deacon C.F., Orskov C., Steiner D.F., and Holst J.J. Impaired intestinal proglucagon processing in mice lacking prohormone convertase 1. Endocrinology 145 (2004) 1349-1355
    • (2004) Endocrinology , vol.145 , pp. 1349-1355
    • Ugleholdt, R.1    Zhu, X.2    Deacon, C.F.3    Orskov, C.4    Steiner, D.F.5    Holst, J.J.6
  • 69
    • 0033525531 scopus 로고    scopus 로고
    • Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals
    • Viale A., Ortola C., Hervieu G., Furuta M., Barbero P., Steiner D.F., et al. Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals. J Biol Chem 274 (1999) 6536-6545
    • (1999) J Biol Chem , vol.274 , pp. 6536-6545
    • Viale, A.1    Ortola, C.2    Hervieu, G.3    Furuta, M.4    Barbero, P.5    Steiner, D.F.6
  • 70
    • 0034726655 scopus 로고    scopus 로고
    • Immunohistochemical evidence for the involvement of protein convertases 5A and 2 in the processing pro-neurotensin in rat brain
    • Villeneuve P., Laforture L., Seidah N.G., Kitabgi P., and Beaudet A. Immunohistochemical evidence for the involvement of protein convertases 5A and 2 in the processing pro-neurotensin in rat brain. J Comp Neurol 424 (2000) 461-475
    • (2000) J Comp Neurol , vol.424 , pp. 461-475
    • Villeneuve, P.1    Laforture, L.2    Seidah, N.G.3    Kitabgi, P.4    Beaudet, A.5
  • 71
    • 0035214561 scopus 로고    scopus 로고
    • Characterization of two forms of cocaine-and amphetamine-regulated transcript (CART) peptide precursors in goldfish: molecular cloning and distribution, modulation of expression by nutritional status, and interactions with leptin
    • Volkoff H., and Peter R.E. Characterization of two forms of cocaine-and amphetamine-regulated transcript (CART) peptide precursors in goldfish: molecular cloning and distribution, modulation of expression by nutritional status, and interactions with leptin. Endocrinology 142 (2001) 5076-5088
    • (2001) Endocrinology , vol.142 , pp. 5076-5088
    • Volkoff, H.1    Peter, R.E.2
  • 72
    • 0034704344 scopus 로고    scopus 로고
    • Effects of CART peptides on food consumption, feeding and associated behaviors in the goldfish, Carassius auratus: actions on neuropeptide Y- and orexin A-induced feeding
    • Volkoff H., and Peter R.E. Effects of CART peptides on food consumption, feeding and associated behaviors in the goldfish, Carassius auratus: actions on neuropeptide Y- and orexin A-induced feeding. Brain Res 887 (2000) 125-133
    • (2000) Brain Res , vol.887 , pp. 125-133
    • Volkoff, H.1    Peter, R.E.2
  • 73
    • 3843149483 scopus 로고    scopus 로고
    • Altered proglucagon processing in an a-cell line derived from prohormone convertase 2 null mouse islets
    • Webb G., Dey A., Wang J., Stein J., Milewski M., and Steiner D.F. Altered proglucagon processing in an a-cell line derived from prohormone convertase 2 null mouse islets. J Biol Chem 279 (2004) 31068-31075
    • (2004) J Biol Chem , vol.279 , pp. 31068-31075
    • Webb, G.1    Dey, A.2    Wang, J.3    Stein, J.4    Milewski, M.5    Steiner, D.F.6
  • 74
    • 0033597852 scopus 로고    scopus 로고
    • Proteolytic processing in the secretory pathway
    • Zhou A., Webb G., Zhu X., and Steiner D.F. Proteolytic processing in the secretory pathway. J Biol Chem 274 (1999) 20745-20748
    • (1999) J Biol Chem , vol.274 , pp. 20745-20748
    • Zhou, A.1    Webb, G.2    Zhu, X.3    Steiner, D.F.4
  • 75
    • 0036678101 scopus 로고    scopus 로고
    • Severe block in processing of proinsulin to insulin accompanied by elevation of des-64, 65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3
    • Zhu X., Orci L., Carroll R., Norrbom C., Ravazzola M., and Steiner D.F. Severe block in processing of proinsulin to insulin accompanied by elevation of des-64, 65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3. Proc Natl Acad Sci USA 99 (2002) 10299-10304
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 10299-10304
    • Zhu, X.1    Orci, L.2    Carroll, R.3    Norrbom, C.4    Ravazzola, M.5    Steiner, D.F.6
  • 76
    • 0036679173 scopus 로고    scopus 로고
    • Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects
    • Zhu X., Zhou A., Dey A., Norrbom C., Carroll R., Zhang C., et al. Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects. Proc Natl Acad Sci USA 99 (2002) 10293-10298
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 10293-10298
    • Zhu, X.1    Zhou, A.2    Dey, A.3    Norrbom, C.4    Carroll, R.5    Zhang, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.