Processing of proSAAS in neuroendocrine cell lines

Biochemical Journal

Volumn 361, Issue 1, 2002, Pages 67-76

  Mzhavia, Nino ^a   QIANt, Yimei ^a   Feng, Yun ^a   Che, Fa Yun ^a   Devi, Lakshmi A ^a   Fricker, Lloyd D ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

7B2; Granin; Neuropeptide; Peptide processing; Pro hormone convertase

Indexed keywords

BIOASSAY; CELLS; CHROMATOGRAPHIC ANALYSIS; MASS SPECTROMETRY; RNA;

CELL LINES;

PROTEINS;

ENZYME INHIBITOR; FURIN; LEUCINE; PROHORMONE CONVERTASE INHIBITOR; PROTEIN PRECURSOR; RNA; SERYLALANYLALANYLSERINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL LINE; CLINICAL PATHWAY; CONTROLLED STUDY; ENZYME INHIBITION; MOUSE; NEUROSECRETORY CELL; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN SECRETION; RAT; REGULATORY MECHANISM;

ANIMALS; ASPARTIC ENDOPEPTIDASES; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GENE EXPRESSION REGULATION; MICE; NEUROPEPTIDES; NEUROSECRETORY SYSTEMS; PC12 CELLS; PROPROTEIN CONVERTASE 1; PROPROTEIN CONVERTASES; PROTEIN PRECURSORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RATS; RECOMBINANT PROTEINS; RNA, MESSENGER; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TRANSFECTION;

ANIMALIA;

EID: 0036177067     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3610067     Document Type: Article

References (47)

1. Proprotein convertase I
2. Prohormone ccnvertase 2
3. Proteolytic processing in the secretory pathway
4. Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2
5. Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, furin, and Kex2: Distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2
6. Identification of the type 2 proinsulin processing endopeptidase as PC2, a member of the eukaryotic subtilisin family
7. The isoforms of proprotein convertase PC5 are sorted to different subcellular compartments
8. Intracellular trafficking and activation of the furin proprotein convertase: Localization to the TGN and recycling from the cell surface
9. Furin: A mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins
10. Identification of a second human subtilisin-like protease gene in the fes/fps region of chromosome 15
11. PACE4: A subtilisin-like endoprotease with unique properties
12. cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinases
13. Enkephalin convertase: Purification and characterization of a specific enkephalin-synthesizing carboxypeptidase localized to adrenal chromaffin granules
14. Carboxypeptidase E/H
15. Intracellular trafficking of metallocarboxypeptidaae D in AtT-20 cells: Localization to the trans-Golgi network and recycling from the cell surface
16. Metallocarboxypeptidase D
17. Glycosylation, phosphorylation, and sulfation of peptide hormones and their precursors
18. Hyperproinsulinemia in obese fatl fat mice associated with a point mutation in the carboxypeptidase E gene and reduced carboxypeptidase E activity in the pancreatic islets
19. 202 of carboxypeptidase E: Effect on enzyme expression, activity, and intracellular routing
20. Carboxypeptidase E activity is deficient in mice with the fat mutation: Effect on peptide processing
21. Impaired processing of brain proneurotensin and promelanin-concentrating hormone in obese fatl fat mice
22. Effect of carboxypeptidase E deficiency on progastrin processing and gastrin mRNA expression in mice with the fat mutation
23. fat mice
24. Identification and characterization of proSAAS, a granin-like neuroendocrine peptide precursor that inhibits prohormone processing
25. fat mice
26. Novel peptides from adrenomedullary chromaffin vesicles
27. 2-terminal sequence of a novel porcine anterior pituitary polypeptide: Homology to proinsulin, secretin and Rous sarcoma virus transforming protein TVFV60
28. Distribution of proSAAS-derived peptides in rat neuroendocrine tissues
29. The neuroendocrine polypeptide 7B2 is an endogenous inhibitor of prohormone convertase PC2
30. Identification of the region within the neuroendocrine polypeptide 7B2 responsible for the inhibition of prohormone convertase PC2
31. The C-terminal region of proSAAS is a potent inhibitor of prohormone convertase 1
32. The SAAS granin exhibits structural and functional homology to 7B2 and contains a highly potent hexapeptide inhibitor of PC1
33. ProSAAS processing in mouse brain and pituitary
34. Expression of neuropeptide processing enzymes and neurosecretory proteins in ependyma and choroid plexux epithelium
35. Prohormone-converting enzymes: Regulation and evaluation of function using antisense RNA
36. Differential modulation of prohormone convertase mRNA by second messenger activators in two cholecystokinin-producing cell lines
37. Downregulation of prohormone convertase-1 by a phorbol ester
38. Tissue distribution and processing of proSAAS by proprotein convertases
39. Mass spectrometric charting of bovine posterior/intermediate pituitary peptides
40. A novel 1745-dalton pyroglutamyl peptide derived from chromogranin B is in the bovine adrenomedullary chromaffin vesicle
41. Chromogranin-B, a putative precursor of eight novel rat glucagonoma peptides through processing at mono-, di-, or tribasic residues
42. Gene for pain modulatory neuropeptide NPFF: Induction in spinal cord by noxious stimuli
43. Processing of chromogranin B in bovine adrenal medulla
44. Endothelin-converting enzyme 1
45. Endothelin-converting enzyme 2
46. Neuroendocrine-specific expression of the human prohormone convertase 1 gene