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Volumn 45, Issue 3, 2006, Pages 289-298

Risk assessment for the carotenoids lutein and lycopene

Author keywords

Carotenoids; Lutein; Lycopene; Observed Safe Level (OSL); Upper Level of Intake (UL)

Indexed keywords

CAROTENOID; LYCOPENE; XANTHOPHYLL;

EID: 33746001403     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2006.05.007     Document Type: Article
Times cited : (90)

References (94)
  • 1
    • 33745997348 scopus 로고    scopus 로고
    • Center for Food Safety and Applied Nutrition. Food and Drug Administration, 2006. Qualified Health Claims. Rockville, MD. http://www.cfsan.fda.gov/~dms/lab-qhc.html.
  • 2
    • 0027397668 scopus 로고    scopus 로고
    • Eye Disease Case-Control Study Group, 1993. Antioxidant status and neovascular age-related macular degeneration. Arch Ophthalmol. 111, 104-109.
  • 3
    • 33745987612 scopus 로고    scopus 로고
    • Food and Nutrition Board. Institute of Medicine, 1997. Dietary reference intakes for calcium, phosphorus, magnesium, vitamin D, and fluoride. National Academy Press, Washington, DC.
  • 4
    • 33746020830 scopus 로고    scopus 로고
    • Food and Nutrition Board. Institute of Medicine, 1998a. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin and Choline. National Academy Press, Washington, DC.
  • 5
    • 33746013785 scopus 로고    scopus 로고
    • Food and Nutrition Board. Institute of Medicine, 1998b. Dietary Reference Intakes: A Risk Assessment Model for Establishing Upper Intake Levels for Nutrients. National Academy Press, Washington, DC.
  • 6
    • 33745978436 scopus 로고    scopus 로고
    • Food and Nutrition Board. Institute of Medicine, 2000. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium and Carotenoids. National Academy Press, Washington, D.C.
  • 7
    • 33745969493 scopus 로고    scopus 로고
    • Food and Nutrition Board. Institute of Medicine, 2001. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium and Zinc. National Academy Press, Washington, DC.
  • 8
    • 33746015647 scopus 로고    scopus 로고
    • Food Standards Agency, 2003. Expert Group on Vitamins and Minerals: Safe Upper Levels for Vitamins and Minerals. United Kingdom.
  • 9
    • 33745998788 scopus 로고    scopus 로고
    • Food and Agriculture Organization/World Health Organization, 2006. A Model for Establishing Upper Levels of Intake for Nutrients and Related Substances. FAO/WHO Technical Workshop on Risk Assessment. Geneva, Switzerland.
  • 10
    • 33746003911 scopus 로고    scopus 로고
    • National Research Council, 1983. Risk Assessment in the Federal Government: Managing the Process. National Academy Press, Washington, DC.
  • 11
    • 84872363044 scopus 로고    scopus 로고
    • NHANES III, 1999. Use of dietary supplements in the United States, 1988-1994. In: Vital and Health Statistics from the Centers for Disease Control and Prevention. National Center for Health Statistics.
  • 12
    • 33745993936 scopus 로고    scopus 로고
    • Scientific Committee on Food, 2001. Guidelines of the Scientific Committee on Food for the Development of Tolerable Upper Intake Levels for Vitamins and Minerals. European Commission, Brussels, Belgium.
  • 16
    • 0041910043 scopus 로고    scopus 로고
    • A comparison of lycopene and orchidectomy vs orchidectomy alone in the management of advanced prostate cancer
    • discussion 378
    • Ansari M.S., and Gupta N.P. A comparison of lycopene and orchidectomy vs orchidectomy alone in the management of advanced prostate cancer. BJU Int. 92 (2003) 375-378 discussion 378
    • (2003) BJU Int. , vol.92 , pp. 375-378
    • Ansari, M.S.1    Gupta, N.P.2
  • 17
    • 0034122112 scopus 로고    scopus 로고
    • Lycopene and cardiovascular disease
    • discussion 1696S-1697S
    • Arab L., and Steck S. Lycopene and cardiovascular disease. Am. J. Clin. Nutr. 71 (2000) 1691S-1695S discussion 1696S-1697S
    • (2000) Am. J. Clin. Nutr. , vol.71
    • Arab, L.1    Steck, S.2
  • 18
    • 0347093697 scopus 로고    scopus 로고
    • DNA damage and susceptibility to oxidative damage in lymphocytes: effects of carotenoids in vitro and in vivo
    • Astley S.B., Hughes D.A., Wright A.J., Elliott R.M., and Southon S. DNA damage and susceptibility to oxidative damage in lymphocytes: effects of carotenoids in vitro and in vivo. Br. J. Nutr. 91 (2004) 53-61
    • (2004) Br. J. Nutr. , vol.91 , pp. 53-61
    • Astley, S.B.1    Hughes, D.A.2    Wright, A.J.3    Elliott, R.M.4    Southon, S.5
  • 19
    • 33745996054 scopus 로고    scopus 로고
    • Lutein supplementation in retinitis pigmentosa: PC-based vision assessment in a randomized double-masked placebo-controlled clinical trial [NCT00029289]
    • Bahrami H., Melia M., and Dagnelie G. Lutein supplementation in retinitis pigmentosa: PC-based vision assessment in a randomized double-masked placebo-controlled clinical trial [NCT00029289]. BMC Ophthalmol. 6 (2006) 23
    • (2006) BMC Ophthalmol. , vol.6 , pp. 23
    • Bahrami, H.1    Melia, M.2    Dagnelie, G.3
  • 20
    • 0023746759 scopus 로고
    • The safety of beta-carotene
    • Bendich A. The safety of beta-carotene. Nutr. Cancer. 11 (1988) 207-214
    • (1988) Nutr. Cancer. , vol.11 , pp. 207-214
    • Bendich, A.1
  • 22
    • 0345269950 scopus 로고    scopus 로고
    • Lutein and zeaxanthin dietary supplements raise macular pigment density and serum concentrations of these carotenoids in humans
    • Bone R.A., Landrum J.T., Guerra L.H., and Ruiz C.A. Lutein and zeaxanthin dietary supplements raise macular pigment density and serum concentrations of these carotenoids in humans. J. Nutr. 133 (2003) 992-998
    • (2003) J. Nutr. , vol.133 , pp. 992-998
    • Bone, R.A.1    Landrum, J.T.2    Guerra, L.H.3    Ruiz, C.A.4
  • 23
    • 0042354087 scopus 로고    scopus 로고
    • Factors affecting intestinal absorption of highly lipophilic food microconstituents (fat-soluble vitamins, carotenoids and phytosterols)
    • Borel P. Factors affecting intestinal absorption of highly lipophilic food microconstituents (fat-soluble vitamins, carotenoids and phytosterols). Clin. Chem. Lab. Med. 41 (2003) 979-994
    • (2003) Clin. Chem. Lab. Med. , vol.41 , pp. 979-994
    • Borel, P.1
  • 24
    • 10344252766 scopus 로고    scopus 로고
    • Effects of supplementing a low-carotenoid diet with a tomato extract for 2 weeks on endogenous levels of DNA single strand breaks and immune functions in healthy non-smokers and smokers
    • Briviba K., Kulling S.E., Moseneder J., Watzl B., Rechkemmer G., and Bub A. Effects of supplementing a low-carotenoid diet with a tomato extract for 2 weeks on endogenous levels of DNA single strand breaks and immune functions in healthy non-smokers and smokers. Carcinogenesis 25 (2004) 2373-2378
    • (2004) Carcinogenesis , vol.25 , pp. 2373-2378
    • Briviba, K.1    Kulling, S.E.2    Moseneder, J.3    Watzl, B.4    Rechkemmer, G.5    Bub, A.6
  • 26
    • 0037991458 scopus 로고    scopus 로고
    • Short-term supplementation with lutein affects biomarkers of lutein status similarly in young and elderly subjects
    • Cardinault N., Gorrand J.M., Tyssandier V., Grolier P., Rock E., and Borel P. Short-term supplementation with lutein affects biomarkers of lutein status similarly in young and elderly subjects. Exp. Gerontol. 38 (2003) 573-582
    • (2003) Exp. Gerontol. , vol.38 , pp. 573-582
    • Cardinault, N.1    Gorrand, J.M.2    Tyssandier, V.3    Grolier, P.4    Rock, E.5    Borel, P.6
  • 27
    • 0031844549 scopus 로고    scopus 로고
    • Bioavailability and bioconversion of carotenoids
    • Castenmiller J.J., and West C.E. Bioavailability and bioconversion of carotenoids. Annu. Rev. Nutr. 18 (1998) 19-38
    • (1998) Annu. Rev. Nutr. , vol.18 , pp. 19-38
    • Castenmiller, J.J.1    West, C.E.2
  • 28
    • 33644675196 scopus 로고    scopus 로고
    • Role of diet in prostate cancer development and progression
    • Chan J.M., Gann P.H., and Giovannucci E.L. Role of diet in prostate cancer development and progression. J. Clin. Oncol. 23 (2005) 8152-8160
    • (2005) J. Clin. Oncol. , vol.23 , pp. 8152-8160
    • Chan, J.M.1    Gann, P.H.2    Giovannucci, E.L.3
  • 31
    • 5644299097 scopus 로고    scopus 로고
    • Comparative multiple dose plasma kinetics of lycopene administered in tomato juice, tomato soup or lycopene tablets
    • Cohn W., Thurmann P., Tenter U., Aebischer C., Schierle J., and Schalch W. Comparative multiple dose plasma kinetics of lycopene administered in tomato juice, tomato soup or lycopene tablets. Eur. J. Nutr. 43 (2004) 304-312
    • (2004) Eur. J. Nutr. , vol.43 , pp. 304-312
    • Cohn, W.1    Thurmann, P.2    Tenter, U.3    Aebischer, C.4    Schierle, J.5    Schalch, W.6
  • 32
    • 0034882534 scopus 로고    scopus 로고
    • Low-dose supplementation with lycopene or beta-carotene does not enhance cell-mediated immunity in healthy free-living elderly humans
    • Corridan B.M., O'Donoghue M., Hughes D.A., and Morrissey P.A. Low-dose supplementation with lycopene or beta-carotene does not enhance cell-mediated immunity in healthy free-living elderly humans. Eur. J. Clin. Nutr. 55 (2001) 627-635
    • (2001) Eur. J. Clin. Nutr. , vol.55 , pp. 627-635
    • Corridan, B.M.1    O'Donoghue, M.2    Hughes, D.A.3    Morrissey, P.A.4
  • 33
    • 2542597666 scopus 로고    scopus 로고
    • Dietary sources of nutrients among US adults, 1994 to 1996
    • Cotton P.A., Subar A.F., Friday J.E., and Cook A. Dietary sources of nutrients among US adults, 1994 to 1996. J. Am. Diet Assoc. 104 (2004) 921-930
    • (2004) J. Am. Diet Assoc. , vol.104 , pp. 921-930
    • Cotton, P.A.1    Subar, A.F.2    Friday, J.E.3    Cook, A.4
  • 34
    • 0034149813 scopus 로고    scopus 로고
    • Lutein improves visual function in some patients with retinal degeneration: a pilot study via the Internet
    • Dagnelie G., Zorge I.S., and McDonald T.M. Lutein improves visual function in some patients with retinal degeneration: a pilot study via the Internet. Optometry 71 (2000) 147-164
    • (2000) Optometry , vol.71 , pp. 147-164
    • Dagnelie, G.1    Zorge, I.S.2    McDonald, T.M.3
  • 36
    • 0037224777 scopus 로고    scopus 로고
    • Influence of short-term antioxidant supplementation on macular function in age-related maculopathy: a pilot study including electrophysiologic assessment
    • discussion 61
    • Falsini B., Piccardi M., Iarossi G., Fadda A., Merendino E., and Valentini P. Influence of short-term antioxidant supplementation on macular function in age-related maculopathy: a pilot study including electrophysiologic assessment. Ophthalmology 110 (2003) 51-60 discussion 61
    • (2003) Ophthalmology , vol.110 , pp. 51-60
    • Falsini, B.1    Piccardi, M.2    Iarossi, G.3    Fadda, A.4    Merendino, E.5    Valentini, P.6
  • 37
    • 1542315589 scopus 로고    scopus 로고
    • The biosynthesis and nutritional uses of carotenoids
    • Fraser P.D., and Bramley P.M. The biosynthesis and nutritional uses of carotenoids. Prog. Lipid Res. 43 (2004) 228-265
    • (2004) Prog. Lipid Res. , vol.43 , pp. 228-265
    • Fraser, P.D.1    Bramley, P.M.2
  • 38
    • 0034767732 scopus 로고    scopus 로고
    • Plasma antioxidant vitamins and carotenoids and age-related cataract
    • Gale C.R., Hall N.F., Phillips D.I., and Martyn C.N. Plasma antioxidant vitamins and carotenoids and age-related cataract. Ophthalmology 108 (2001) 1992-1998
    • (2001) Ophthalmology , vol.108 , pp. 1992-1998
    • Gale, C.R.1    Hall, N.F.2    Phillips, D.I.3    Martyn, C.N.4
  • 39
    • 1842292747 scopus 로고    scopus 로고
    • Lycopene is more bioavailable from tomato paste than from fresh tomatoes
    • Gartner C., Stahl W., and Sies H. Lycopene is more bioavailable from tomato paste than from fresh tomatoes. Am. J. Clin. Nutr. 66 (1997) 116-122
    • (1997) Am. J. Clin. Nutr. , vol.66 , pp. 116-122
    • Gartner, C.1    Stahl, W.2    Sies, H.3
  • 40
    • 23244451391 scopus 로고    scopus 로고
    • Tomato products, lycopene, and prostate cancer: a review of the epidemiological literature
    • Giovannucci E. Tomato products, lycopene, and prostate cancer: a review of the epidemiological literature. J. Nutr. 135 (2005) 2030S-2031S
    • (2005) J. Nutr. , vol.135
    • Giovannucci, E.1
  • 41
    • 0034093998 scopus 로고    scopus 로고
    • Dose dependency of canthaxanthin crystals in monkey retina and spatial distribution of its metabolites
    • Goralczyk R., Barker F.M., Buser S., Liechti H., and Bausch J. Dose dependency of canthaxanthin crystals in monkey retina and spatial distribution of its metabolites. Invest. Ophthalmol Vis. Sci. 41 (2000) 1513-1522
    • (2000) Invest. Ophthalmol Vis. Sci. , vol.41 , pp. 1513-1522
    • Goralczyk, R.1    Barker, F.M.2    Buser, S.3    Liechti, H.4    Bausch, J.5
  • 42
    • 0030935617 scopus 로고    scopus 로고
    • Occurrence of birefringent retinal inclusions in cynomolgus monkeys after high doses of canthaxanthin
    • Goralczyk R., Buser S., Bausch J., Bee W., Zuhlke U., and Barker F.M. Occurrence of birefringent retinal inclusions in cynomolgus monkeys after high doses of canthaxanthin. Invest. Ophthalmol. Vis. Sci. 38 (1997) 741-752
    • (1997) Invest. Ophthalmol. Vis. Sci. , vol.38 , pp. 741-752
    • Goralczyk, R.1    Buser, S.2    Bausch, J.3    Bee, W.4    Zuhlke, U.5    Barker, F.M.6
  • 43
    • 0031793171 scopus 로고    scopus 로고
    • Lutein ester in serum after lutein supplementation in human subjects
    • Granado F., Olmedilla B., Gil-Martinez E., and Blanco I. Lutein ester in serum after lutein supplementation in human subjects. Br. J. Nutr. 80 (1998) 445-449
    • (1998) Br. J. Nutr. , vol.80 , pp. 445-449
    • Granado, F.1    Olmedilla, B.2    Gil-Martinez, E.3    Blanco, I.4
  • 44
    • 0003634520 scopus 로고    scopus 로고
    • Council for Responsible Nutrition, Washington, DC
    • Hathcock J. Vitamin and Mineral Safety (2004), Council for Responsible Nutrition, Washington, DC
    • (2004) Vitamin and Mineral Safety
    • Hathcock, J.1
  • 47
    • 0141988903 scopus 로고    scopus 로고
    • Synthetic and tomato-based lycopene have identical bioavailability in humans
    • Hoppe P.P., Kramer K., van den Berg H., Steenge G., and van Vliet T. Synthetic and tomato-based lycopene have identical bioavailability in humans. Eur. J. Nutr. 42 (2003) 272-278
    • (2003) Eur. J. Nutr. , vol.42 , pp. 272-278
    • Hoppe, P.P.1    Kramer, K.2    van den Berg, H.3    Steenge, G.4    van Vliet, T.5
  • 48
    • 2542426074 scopus 로고    scopus 로고
    • Lycopene and beta-carotene are bioavailable from lycopene 'red' carrots in humans
    • Horvitz M.A., Simon P.W., and Tanumihardjo S.A. Lycopene and beta-carotene are bioavailable from lycopene 'red' carrots in humans. Eur. J. Clin. Nutr. 58 (2004) 803-811
    • (2004) Eur. J. Clin. Nutr. , vol.58 , pp. 803-811
    • Horvitz, M.A.1    Simon, P.W.2    Tanumihardjo, S.A.3
  • 49
    • 0033817671 scopus 로고    scopus 로고
    • Effects of lycopene and lutein supplementation on the expression of functionally associated surface molecules on blood monocytes from healthy male nonsmokers
    • Hughes D.A., Wright A.J., Finglas P.M., Polley A.C., Bailey A.L., Astley S.B., and Southon S. Effects of lycopene and lutein supplementation on the expression of functionally associated surface molecules on blood monocytes from healthy male nonsmokers. J. Infect. Dis. 182 Suppl 1 (2000) S11-S15
    • (2000) J. Infect. Dis. , vol.182 , Issue.SUPPL. 1
    • Hughes, D.A.1    Wright, A.J.2    Finglas, P.M.3    Polley, A.C.4    Bailey, A.L.5    Astley, S.B.6    Southon, S.7
  • 50
    • 0033637343 scopus 로고    scopus 로고
    • Natural tocopherols in a dietary supplement of lutein affect tissue distribution of tocopherols in young rats
    • Jenkins M.Y., Mitchell G.V., and Grundel E. Natural tocopherols in a dietary supplement of lutein affect tissue distribution of tocopherols in young rats. Nutr. Cancer 37 (2000) 207-214
    • (2000) Nutr. Cancer , vol.37 , pp. 207-214
    • Jenkins, M.Y.1    Mitchell, G.V.2    Grundel, E.3
  • 51
    • 0036490691 scopus 로고    scopus 로고
    • The role of carotenoids in human health
    • Johnson E.J. The role of carotenoids in human health. Nutr. Clin. Care. 5 (2002) 56-65
    • (2002) Nutr. Clin. Care. , vol.5 , pp. 56-65
    • Johnson, E.J.1
  • 54
    • 0031570089 scopus 로고    scopus 로고
    • Identification, quantification, and relative concentrations of carotenoids and their metabolites in human milk and serum
    • Khachik F., Spangler C.J., Smith Jr. J.C., Canfield L.M., Steck A., and Pfander H. Identification, quantification, and relative concentrations of carotenoids and their metabolites in human milk and serum. Anal. Chem. 69 (1997) 1873-1881
    • (1997) Anal. Chem. , vol.69 , pp. 1873-1881
    • Khachik, F.1    Spangler, C.J.2    Smith Jr., J.C.3    Canfield, L.M.4    Steck, A.5    Pfander, H.6
  • 55
    • 2942534287 scopus 로고    scopus 로고
    • Plasma and macular responses to lutein supplement in subjects with and without age-related maculopathy: a pilot study
    • Koh H.H., Murray I.J., Nolan D., Carden D., Feather J., and Beatty S. Plasma and macular responses to lutein supplement in subjects with and without age-related maculopathy: a pilot study. Exp. Eye Res. 79 (2004) 21-27
    • (2004) Exp. Eye Res. , vol.79 , pp. 21-27
    • Koh, H.H.1    Murray, I.J.2    Nolan, D.3    Carden, D.4    Feather, J.5    Beatty, S.6
  • 56
    • 0036050153 scopus 로고    scopus 로고
    • An innovative approach to the determination of safety for a dietary ingredient derived from a new source: case study using a crystalline lutein product
    • Kruger C.L., Murphy M., DeFreitas Z., Pfannkuch F., and Heimbach J. An innovative approach to the determination of safety for a dietary ingredient derived from a new source: case study using a crystalline lutein product. Food Chem. Toxicol. 40 (2002) 1535-1549
    • (2002) Food Chem. Toxicol. , vol.40 , pp. 1535-1549
    • Kruger, C.L.1    Murphy, M.2    DeFreitas, Z.3    Pfannkuch, F.4    Heimbach, J.5
  • 60
    • 0034775358 scopus 로고    scopus 로고
    • Lutein, zeaxanthin, and the macular pigment
    • Landrum J.T., and Bone R.A. Lutein, zeaxanthin, and the macular pigment. Arch. Biochem. Biophys. 385 (2001) 28-40
    • (2001) Arch. Biochem. Biophys. , vol.385 , pp. 28-40
    • Landrum, J.T.1    Bone, R.A.2
  • 62
    • 0038407714 scopus 로고    scopus 로고
    • Lycopene supplementation inhibits lung squamous metaplasia and induces apoptosis via up-regulating insulin-like growth factor-binding protein 3 in cigarette smoke-exposed ferrets
    • Liu C., Lian F., Smith D.E., Russell R.M., and Wang X.D. Lycopene supplementation inhibits lung squamous metaplasia and induces apoptosis via up-regulating insulin-like growth factor-binding protein 3 in cigarette smoke-exposed ferrets. Cancer Res. 63 (2003) 3138-3144
    • (2003) Cancer Res. , vol.63 , pp. 3138-3144
    • Liu, C.1    Lian, F.2    Smith, D.E.3    Russell, R.M.4    Wang, X.D.5
  • 63
    • 31544471790 scopus 로고    scopus 로고
    • Lycopene supplementation prevents smoke-induced changes in p53, p53 phosphorylation, cell proliferation, and apoptosis in the gastric mucosa of ferrets
    • Liu C., Russell R.M., and Wang X.D. Lycopene supplementation prevents smoke-induced changes in p53, p53 phosphorylation, cell proliferation, and apoptosis in the gastric mucosa of ferrets. J. Nutr. 136 (2006) 106-111
    • (2006) J. Nutr. , vol.136 , pp. 106-111
    • Liu, C.1    Russell, R.M.2    Wang, X.D.3
  • 64
    • 0033135123 scopus 로고    scopus 로고
    • Antioxidant intake and risk of incident age-related nuclear cataracts in the Beaver Dam Eye Study
    • Lyle B.J., Mares-Perlman J.A., Klein B.E., Klein R., and Greger J.L. Antioxidant intake and risk of incident age-related nuclear cataracts in the Beaver Dam Eye Study. Am. J. Epidemiol. 149 (1999) 801-809
    • (1999) Am. J. Epidemiol. , vol.149 , pp. 801-809
    • Lyle, B.J.1    Mares-Perlman, J.A.2    Klein, B.E.3    Klein, R.4    Greger, J.L.5
  • 65
    • 0035283350 scopus 로고    scopus 로고
    • Lutein and zeaxanthin in the diet and serum and their relation to age-related maculopathy in the third national health and nutrition examination survey
    • Mares-Perlman J.A., Fisher A.I., Klein R., Palta M., Block G., Millen A.E., and Wright J.D. Lutein and zeaxanthin in the diet and serum and their relation to age-related maculopathy in the third national health and nutrition examination survey. Am. J. Epidemiol. 153 (2001) 424-432
    • (2001) Am. J. Epidemiol. , vol.153 , pp. 424-432
    • Mares-Perlman, J.A.1    Fisher, A.I.2    Klein, R.3    Palta, M.4    Block, G.5    Millen, A.E.6    Wright, J.D.7
  • 67
    • 2342507705 scopus 로고    scopus 로고
    • Safety evaluation of a natural tomato oleoresin extract derived from food-processing tomatoes
    • Matulka R.A., Hood A.M., and Griffiths J.C. Safety evaluation of a natural tomato oleoresin extract derived from food-processing tomatoes. Regul. Toxicol. Pharmacol. 39 (2004) 390-402
    • (2004) Regul. Toxicol. Pharmacol. , vol.39 , pp. 390-402
    • Matulka, R.A.1    Hood, A.M.2    Griffiths, J.C.3
  • 68
    • 0037399173 scopus 로고    scopus 로고
    • Summary of safety studies conducted with synthetic lycopene
    • McClain R.M., and Bausch J. Summary of safety studies conducted with synthetic lycopene. Regul. Toxicol. Pharmacol. 37 (2003) 274-285
    • (2003) Regul. Toxicol. Pharmacol. , vol.37 , pp. 274-285
    • McClain, R.M.1    Bausch, J.2
  • 69
    • 0033781522 scopus 로고    scopus 로고
    • Reduction of exercise-induced asthma oxidative stress by lycopene, a natural antioxidant
    • Neuman I., Nahum H., and Ben-Amotz A. Reduction of exercise-induced asthma oxidative stress by lycopene, a natural antioxidant. Allergy 55 (2000) 1184-1189
    • (2000) Allergy , vol.55 , pp. 1184-1189
    • Neuman, I.1    Nahum, H.2    Ben-Amotz, A.3
  • 70
    • 0037221102 scopus 로고    scopus 로고
    • Lutein, but not alpha-tocopherol, supplementation improves visual function in patients with age-related cataracts: a 2-y double-blind, placebo-controlled pilot study
    • Olmedilla B., Granado F., Blanco I., and Vaquero M. Lutein, but not alpha-tocopherol, supplementation improves visual function in patients with age-related cataracts: a 2-y double-blind, placebo-controlled pilot study. Nutrition 19 (2003) 21-24
    • (2003) Nutrition , vol.19 , pp. 21-24
    • Olmedilla, B.1    Granado, F.2    Blanco, I.3    Vaquero, M.4
  • 73
    • 0031796421 scopus 로고    scopus 로고
    • Chronic ingestion of lycopene-rich tomato juice or lycopene supplements significantly increases plasma concentrations of lycopene and related tomato carotenoids in humans
    • Paetau I., Khachik F., Brown E.D., Beecher G.R., Kramer T.R., Chittams J., and Clevidence B.A. Chronic ingestion of lycopene-rich tomato juice or lycopene supplements significantly increases plasma concentrations of lycopene and related tomato carotenoids in humans. Am. J. Clin. Nutr. 68 (1998) 1187-1195
    • (1998) Am. J. Clin. Nutr. , vol.68 , pp. 1187-1195
    • Paetau, I.1    Khachik, F.2    Brown, E.D.3    Beecher, G.R.4    Kramer, T.R.5    Chittams, J.6    Clevidence, B.A.7
  • 74
    • 0032881951 scopus 로고    scopus 로고
    • Carotenoids in human buccal mucosa cells after 4 wk of supplementation with tomato juice or lycopene supplements
    • Paetau I., Rao D., Wiley E.R., Brown E.D., and Clevidence B.A. Carotenoids in human buccal mucosa cells after 4 wk of supplementation with tomato juice or lycopene supplements. Am. J. Clin. Nutr. 70 (1999) 490-494
    • (1999) Am. J. Clin. Nutr. , vol.70 , pp. 490-494
    • Paetau, I.1    Rao, D.2    Wiley, E.R.3    Brown, E.D.4    Clevidence, B.A.5
  • 75
    • 0031752935 scopus 로고    scopus 로고
    • Bioavailability and in vivo antioxidant properties of lycopene from tomato products and their possible role in the prevention of cancer
    • Rao A.V., and Agarwal S. Bioavailability and in vivo antioxidant properties of lycopene from tomato products and their possible role in the prevention of cancer. Nutr. Cancer 31 (1998) 199-203
    • (1998) Nutr. Cancer , vol.31 , pp. 199-203
    • Rao, A.V.1    Agarwal, S.2
  • 76
    • 33745977426 scopus 로고
    • Lycopenemia: a variant of carotenemia
    • Reigh P. Lycopenemia: a variant of carotenemia. New Engl. J. Med. 80 (1960) 353-361
    • (1960) New Engl. J. Med. , vol.80 , pp. 353-361
    • Reigh, P.1
  • 77
    • 0036192664 scopus 로고    scopus 로고
    • A food-based formulation provides lycopene with the same bioavailability to humans as that from tomato paste
    • Richelle M., Bortlik K., Liardet S., Hager C., Lambelet P., Baur M., Applegate L.A., and Offord E.A. A food-based formulation provides lycopene with the same bioavailability to humans as that from tomato paste. J. Nutr. 132 (2002) 404-408
    • (2002) J. Nutr. , vol.132 , pp. 404-408
    • Richelle, M.1    Bortlik, K.2    Liardet, S.3    Hager, C.4    Lambelet, P.5    Baur, M.6    Applegate, L.A.7    Offord, E.A.8
  • 78
    • 0032610718 scopus 로고    scopus 로고
    • ARMD-pilot (case series) environmental intervention data
    • Richer S. ARMD-pilot (case series) environmental intervention data. J. Am. Optom. Assoc. 70 (1999) 24-36
    • (1999) J. Am. Optom. Assoc. , vol.70 , pp. 24-36
    • Richer, S.1
  • 79
    • 2542432254 scopus 로고    scopus 로고
    • Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial)
    • Richer S., Stiles W., Statkute L., Pulido J., Frankowski J., Rudy D., Pei K., Tsipursky M., and Nyland J. Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: the Veterans LAST study (Lutein Antioxidant Supplementation Trial). Optometry 75 (2004) 216-230
    • (2004) Optometry , vol.75 , pp. 216-230
    • Richer, S.1    Stiles, W.2    Statkute, L.3    Pulido, J.4    Frankowski, J.5    Rudy, D.6    Pei, K.7    Tsipursky, M.8    Nyland, J.9
  • 80
    • 0034014433 scopus 로고    scopus 로고
    • Amount of fat in the diet affects bioavailability of lutein esters but not of alpha-carotene, beta-carotene, and vitamin E in humans
    • Roodenburg A.J., Leenen R., van het Hof K.H., Weststrate J.A., and Tijburg L.B. Amount of fat in the diet affects bioavailability of lutein esters but not of alpha-carotene, beta-carotene, and vitamin E in humans. Am. J. Clin. Nutr. 71 (2000) 1187-1193
    • (2000) Am. J. Clin. Nutr. , vol.71 , pp. 1187-1193
    • Roodenburg, A.J.1    Leenen, R.2    van het Hof, K.H.3    Weststrate, J.A.4    Tijburg, L.B.5
  • 81
    • 0034102805 scopus 로고    scopus 로고
    • The vitamin A spectrum: from deficiency to toxicity
    • Russell R.M. The vitamin A spectrum: from deficiency to toxicity. Am. J. Clin. Nutr. 71 (2000) 878-884
    • (2000) Am. J. Clin. Nutr. , vol.71 , pp. 878-884
    • Russell, R.M.1
  • 82
    • 0346095553 scopus 로고    scopus 로고
    • The enigma of beta-carotene in carcinogenesis: what can be learned from animal studies
    • Russell R.M. The enigma of beta-carotene in carcinogenesis: what can be learned from animal studies. J. Nutr. 134 (2004) 262S-268S
    • (2004) J. Nutr. , vol.134
    • Russell, R.M.1
  • 85
    • 23444460256 scopus 로고    scopus 로고
    • Plasma kinetics of lutein, zeaxanthin, and 3-dehydro-lutein after multiple oral doses of a lutein supplement
    • Thurmann P.A., Schalch W., Aebischer J.C., Tenter U., and Cohn W. Plasma kinetics of lutein, zeaxanthin, and 3-dehydro-lutein after multiple oral doses of a lutein supplement. Am. J. Clin. Nutr. 82 (2005) 88-97
    • (2005) Am. J. Clin. Nutr. , vol.82 , pp. 88-97
    • Thurmann, P.A.1    Schalch, W.2    Aebischer, J.C.3    Tenter, U.4    Cohn, W.5
  • 86
    • 23244438096 scopus 로고    scopus 로고
    • How do intermediate endpoint markers respond to lycopene in men with prostate cancer or benign prostate hyperplasia?
    • van Breemen R.B. How do intermediate endpoint markers respond to lycopene in men with prostate cancer or benign prostate hyperplasia?. J. Nutr. 135 (2005) 2062S-2064S
    • (2005) J. Nutr. , vol.135
    • van Breemen, R.B.1
  • 87
    • 23244449227 scopus 로고    scopus 로고
    • Can smoke-exposed ferrets be utilized to unravel the mechanisms of action of lycopene?
    • Wang X.D. Can smoke-exposed ferrets be utilized to unravel the mechanisms of action of lycopene?. J. Nutr. 135 (2005) 2053S-2056S
    • (2005) J. Nutr. , vol.135
    • Wang, X.D.1
  • 88
    • 0033528079 scopus 로고    scopus 로고
    • Retinoid signaling and activator protein-1 expression in ferrets given beta-carotene supplements and exposed to tobacco smoke
    • Wang X.D., Liu C., Bronson R.T., Smith D.E., Krinsky N.I., and Russell M. Retinoid signaling and activator protein-1 expression in ferrets given beta-carotene supplements and exposed to tobacco smoke. J. Natl. Cancer Inst. 91 (1999) 60-66
    • (1999) J. Natl. Cancer Inst. , vol.91 , pp. 60-66
    • Wang, X.D.1    Liu, C.2    Bronson, R.T.3    Smith, D.E.4    Krinsky, N.I.5    Russell, M.6
  • 89
    • 0343962137 scopus 로고    scopus 로고
    • Prolonged tomato juice consumption has no effect on cell-mediated immunity of well-nourished elderly men and women
    • Watzl B., Bub A., Blockhaus M., Herbert B.M., Luhrmann P.M., Neuhauser-Berthold M., and Rechkemmer G. Prolonged tomato juice consumption has no effect on cell-mediated immunity of well-nourished elderly men and women. J. Nutr. 130 (2000) 1719-1723
    • (2000) J. Nutr. , vol.130 , pp. 1719-1723
    • Watzl, B.1    Bub, A.2    Blockhaus, M.3    Herbert, B.M.4    Luhrmann, P.M.5    Neuhauser-Berthold, M.6    Rechkemmer, G.7
  • 90
    • 1342333678 scopus 로고    scopus 로고
    • Supplementation of a low-carotenoid diet with tomato or carrot juice modulates immune functions in healthy men
    • Watzl B., Bub A., Briviba K., and Rechkemmer G. Supplementation of a low-carotenoid diet with tomato or carrot juice modulates immune functions in healthy men. Ann. Nutr. Metab. 47 (2003) 255-261
    • (2003) Ann. Nutr. Metab. , vol.47 , pp. 255-261
    • Watzl, B.1    Bub, A.2    Briviba, K.3    Rechkemmer, G.4
  • 91
    • 0031775340 scopus 로고    scopus 로고
    • Quantification of the "SLAMENGHI" factors for carotenoid bioavailability and bioconversion
    • West C.E., and Castenmiller J.J. Quantification of the "SLAMENGHI" factors for carotenoid bioavailability and bioconversion. Int. J. Vitam. Nutr. Res. 68 (1998) 371-377
    • (1998) Int. J. Vitam. Nutr. Res. , vol.68 , pp. 371-377
    • West, C.E.1    Castenmiller, J.J.2
  • 93
    • 0028839561 scopus 로고
    • Measurement of carotenoids, retinoids, and tocopherols in human lenses
    • Yeum K.J., Taylor A., Tang G., and Russell R.M. Measurement of carotenoids, retinoids, and tocopherols in human lenses. Invest. Ophthalmol. Vis. Sci. 36 (1995) 2756-2761
    • (1995) Invest. Ophthalmol. Vis. Sci. , vol.36 , pp. 2756-2761
    • Yeum, K.J.1    Taylor, A.2    Tang, G.3    Russell, R.M.4


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