Presence of sodium dodecyl sulfate-stable amyloid β-protein dimers in the hippocampus CA1 not exhibiting neurofibrillary tangle formation

American Journal of Pathology

Volumn 155, Issue 1, 1999, Pages 23-28

  Funato, Hiromasa ^a,b   Enya, Miho ^a   Yoshimura, Masahiro ^a   Morishima Kawashima, Maho ^a   Ihara, Yasuo ^a,c,d  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; DODECYL SULFATE SODIUM;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; AUTOPSY; DIMERIZATION; ENZYME IMMUNOASSAY; FEMALE; HIPPOCAMPUS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; MALE; NERVE CELL NECROSIS; NEUROFIBRILLARY TANGLE; OCCIPITAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENILE PLAQUE; STAINING; TEMPORAL CORTEX;

EID: 0032983254     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)65094-8     Document Type: Article

References (32)

1. Hardy J: Amyloid, the presenilins and Alzheimer's disease. Trends Neurosci 1997, 20:154-159
2. Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, Bird TD, Hardy J, Hutton M, Kukull W, Larson E, Levy-Lahad E, Viitanen M, Peskind E, Poorkaj P, Schellenberg G, Tanzi R, Wasco W, Lannfelt L, Selkoe D, Younkin S: Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med 1996, 2:864-870
3. Jarrett JT, Berger EP, Lansbury PT Jr: The carboxy terminus of the β amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. Biochemistry 1993, 32:4693-4697
4. Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y: Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: evidence that an initially deposited species is Aβ42(43). Neuron 1994, 13:45-53
5. Iwatsubo T, Mann DMA, Odaka A, Suzuki N, Ihara Y: Amyloid β-protein (Aβ) deposition: Aβ42(43) precedes Aβ40 in Down's syndrome. Ann Neurol 1995, 37:294-299
6. Pike CJ, Burdick D, Walencewicz AJ, Glabe CG, Cotman CW: Neurodegeneration induced by β-amyloid peptides in vitro: the role of peptide assembly state. J Neurosci 1993, 13:1676-1667
7. Lorenzo A, Yankner BA: β-Amyloid neurotoxicity requires fibril formation and is inhibited by Congo red. Proc Natl Acad Sci USA 1994, 91:12243-12247
8. Behl C, Davis JB, Lesley R, Schubert D: Hydrogen peroxide mediates amyloid β protein toxicity. Cell 1994, 77:817-827
9. Dickson DW, Crystal HA, Mattiace LA, Masur DM, Blau AD, Davies P, Yen SH, Aronson MK: Identification of normal and pathological aging in prospectively studied nondemented elderly humans. Neurobiol Aging 1992, 13:179-189
10. Braak H, Braak E: Neuropathological staging of Alzheimer-related changes. Acta Neuropathol 1991, 82:239-259
11. Langui D, Probst A, Ulrich J: Alzheimer's changes in non-demented and demented patients: a statistical approach to their relationships. Acta Neuropathol 1995, 89:57-62
12. Jellinger KA: Alzheimer's changes in non-demented and demented patients. Acta Neuropathol 1995, 89:112-113
13. Gómez-Isla T, Price JL, McKeel DW Jr, Morris JC, Growdon JH, Hyman BT: Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease. J Neurosci 1996, 16:4491-4500
14. Irizarry MC, Soriano F, McNamara M, Page KJ, Schenk D, Games D, Hyman BT: Aβ deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse. J Neurosci 1997, 17:7053-7059
15. SW transgenic mice develop age-related Aβ deposits and neuropil abnormalities, but no neuronal loss in CA1. J Neuropathol Exp Neurol 1997, 56:965-973
16. Enya M, Morishima-Kawashima M, Yoshimura M, Shinkai Y, Kusui K, Khan K, Games D, Schenk D, Sugihara S, Yamaguchi H, Ihara Y: Appearance of sodium dodecyl sulfate-stable amyloid β-protein (Aβ) dimer in the cortex during aging. Am J Pathol 1999, 154:271-279
17. Funato H, Yoshimura M, Kusui K, Tamaoka A, Ishikawa K, Ohkoshi N, Namekata K, Okeda R, Ihara Y: Quantitation of amyloid β-protein (Aβ) in the cortex during aging and in Alzheimer's disease. Am J Pathol 1998, 152:1633-1640
18. Tierney MC, Fisher H, Lewis AJ: The NINCDS-ADRDA Work Group criteria for the clinical diagnosis of probable Alzheimer's disease: clinicopathological study of 57 cases. Neurology 1988, 38:356-364
19. Mirra SS, Heyman A, McKee D, Sumi SM, Crain BJ, Brownlee LM, Vogel FS, Hughes JP, van Belle G, Berg L, participating CERAD neuropathologists: The consortium to establish a registry for Alzheimer's disease (CERAD). II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 1991, 42:1681-1688
20. Shinkai Y, Yoshimura M, Morishima-Kawashima M, Ito Y, Shimada H, Yanagisawa K, Ihara Y: Amyloid β-protein deposition in the leptomeninges and cerebral cortex. Ann Neurol 1997, 42:899-908
21. Ida N, Hartmann T, Pantel J, Schroeder J, Zerfass R, Foerstl H, Sandbrink R, Masters CL, Beyreuther K: Analysis of heterogenous βA4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay. J Biol Chem 1996, 271: 22908-22914
22. Bruce AJ, Malfroy B, Baudry M: β-Amyloid toxicity in organotypic hippocampal cultures: protection by EUK-8, a synthetic catalytic free radical scavenger. Proc Natl Acad Sci USA 1996, 93:2312-2316
23. Vickers JC: A cellular mechanisms for the neuronal changes underlying Alzheimer's disease. Neuroscience 1997, 78:629-639
24. McBain CJ, Traynelis SF, Dingledine R: Regional variation of extracellular space in the hippocampus. Science 1990, 249:674-677
25. Takagi H, Shapiro K, Marmarou A, Wisoff H: Microgravimetric analysis of human brain tissue: correlation with computerized tomography scanning. J Neurosurg 1981, 54:797-801
26. Lambert MP, Barlow AK, Chromy BA, Edwards C, Freed R, Liosatos M, Morgan TE, Rozovsky I, Trommer B, Viola KL, Wals P, Zhang C, Finch CE, Kraftt GA, Klein WL: Diffusible, nonfibrillar ligands derived from Aβ1-42 are potent central nervous system neurotoxins. Proc Natl Acad Sci USA 1998, 95:6448-6453
27. Kuo YM, Webster S, Emmerling MR, De Lima N, Roher AE: Irreversible dimerization/tetramerization and post-translational modifications inhibit proteolytic degradation of Aβ peptides of Alzheimer's disease. Biochim Biophys Acta 1998, 1406:291-298
28. Podlisny MB, Ostaszewski BL, Squazzo SL, Koo EH, Rydell RE, Teplow DB, Selkoe DJ: Aggregation of secreted amyloid β-protein into sodium dodecyl sulfate-stable oligomers in cell culture. J Biol Chem 1995, 270:9564-9570
29. Xia W, Zhang J, Kholodenko D, Citron M, Podlisny MB, Teplow DB, Haass C, Seubert P, Koo EH, Selkoe DJ: Enhanced production and oligomerization of the 42-residue amyloid β-protein by Chinese hamster ovary cells stably expressing mutant presenilins. J Biol Chem 1997, 272:7977-7982
30. Podlisny MB, Walsh DM, Amarante P, Ostaszewski BL, Stimson ER, Maggio JE, Teplow DB, Selkoe DJ: Oligomerization of endogenous and synthetic amyloid β-protein at nanomolar levels in cell culture and stabilization of monomer by Congo red. Biochemistry 1998, 37:3602-3611
31. Morishima-Kawashima M, Ihara Y: The presence of amyloid β-protein in the detergent-insoluble membrane compartment of human neuroblastoma cells. Biochemistry 1998, 37:15247-15253
32. Watanabe A, Takio K, Ihara Y: Deamidation and isoaspartate formation in smeared tau in paired helical filaments: unusual properties of the microtubule-binding domain of tau. J Biol Chem 1999, 274:7368-7378