Origin of projections from the midbrain raphe nuclei to the hypothalamic paraventricular nucleus in the rat: A combined retrograde and anterograde tracing study

Neuroscience

Volumn 70, Issue 4, 1996, Pages 963-988

  Larsen, P J ^a   Hay Schmidt, A ^b   Vrang, N ^b   Mikkelsen, J D ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NONE

Author keywords

choleratoxin subunit B; FluoroGold; Phaseolus vulgaris leucoagglutinin; rat; Rhodamine labelled latex microspheres; serotonin

Indexed keywords

CHOLERA TOXIN; MICROSPHERE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HISTOCHEMISTRY; HYPOTHALAMUS; IMMUNOGOLD STAINING; MALE; NERVE PROJECTION; NONHUMAN; PHASEOLUS VULGARIS; PRIORITY JOURNAL; RAPHE NUCLEUS; RAT; THALAMUS MIDLINE NUCLEUS;

EID: 0030023233     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/0306-4522(95)00415-7     Document Type: Article

References (62)

1. Aghajanian G. K. and Gallager D. W. (1975) Raphe origin of serotonergic nerves terminating in the cerebral ventricles. Brain Res. 88, 221-231.
2. Azmitia E. C. and Segal M. (1978) An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat. J. comp. Neural. 179, 641-688.
3. Bagdy G., Calogero A. E., Murphy D. L. and Szmeredi K. (1989) Serotonin agonists cause parallel activation of the sympathoadrenomedullary system and the hypothalamo-pituitary adrenocortical axis in conscious rats. Endocrinology 125, 2664-2669.
4. 1C receptors induce oxytocin release in the male rat. Brain Res. 611, 330-332.
5. Basbaum A. I. and Fields H. L. (1979) The origin of descending pathways in the dorsolateral funiculus of the spinal cord of the cat and rat: further studies on the anatomy of pain modulation. J. comp. Neurol. 187, 513-532.
6. Bicknell R. J. and Leng G. (1982) Endogenous opiates regulate oxytocin but not vasopressin secretion from the neurohypophysis. Nature 298, 161-162.
7. Bisset G. W. and Chowdrey H, S. (1988) Control of release of vasopressin by neuroendocrine reflexes. Q. Jl exp. Physiol. 73, 811-872.
8. Björklund A. and Skagerberg G. (1979) Simultaneous use of retrograde fluorescent tracers and fluorescence histochemistry for convenient and precise mapping of monoaminergic projections and collateral arrangements in the CNS. J. Neurosci. Meth. 1, 261-277.
9. Brown M. R., Carvr-Moore K., Gray T. S. and Rivier C. (1989) Thyrotropin-releasing factor-induce adrenocorticotropin secretion is mediated by corticotropin-releasing factor. Endocrinology 125, 2558-2562.
10. Calogero A. E., Bernardini R., Margioris A. N., Bagdy G., Galluci W. T., Munson P. J., Tamerkin L., Tomai T. P., Brady L., Gold P. W. and Chrousos G. P. (1989) Effects of serotonergic agonists and antagonists on corticotropin-releasing hormone secretion by explanted rat hypothalamus. Peptides 10, 1898-200.
11. Dunn A. J. (1988) Changes in plasma and brain tryptophan and brain serotonin and 5-hydroxyindolacetic acid after footshock stress. Life Sci. 42, 1847-1853.
12. Feldman S., Weidenfeld J., Conforti N. and Saphier D. (1991) Differential recovery of adrenocortical responses to neural stimuli following administration of 5,7-dihyroxytryptamine into the hypothalamus. Exp. Brain Res. 85, 661-666.
13. Fornal C. A., Litto W. J., Morilak D. A. and Jacobs B. L. (1989) Single-unit responses of serotonergic neurons to glucose and insulin administration in behaving cats. Am. J. Physiol. 257, 1345-1353.
14. Fornal C. A., Litto W. J., Morilak D. A. and Jacobs B. L. (1990) Single-unit responses of serotonergic neurons to vasoactive drug administration in behaving cats. Am. J. Physiol. 259, 963-972.
15. Frankfurt M. and Azmitia E. (1983) The effect of intracerebral injections of 5,7-dihydroxytryptamine and 6-hydroxydopamine on the serotonin-immunoreactive cell bodies and fibers in the adult rat hypothalamus. Brain Res. 261, 91-99.
16. Fuller R. W. (1990) Serotonin receptors and neurodendocrine responses. Neuropsychopharmacology 3, 495-502.
17. Fuller R. W. and Snoddy H. D. (1980) Effect of serotonin-releasing drugs on serum corticosterone concentrations in rats. Neuroendocrinology 31, 96-100.
18. Harbuz M. S., Chalmers J., De Souza L. and Lightman S. L. (1993) Stress-induced activation of CRF and c-fos mRNAs in the paraventricular nucleus are not affected by serotonin depletion. Brain Res. 609, 167-173.
19. Hatton G. I. (1990) Emerging concepts of structure function dynamics in adult brain: the hypothalamo-neurohypophysial system. Prog. Neurobiol. 34, 437-504.
20. Imai H., Steindler D. A. and Kitai S. T. (1986) The organization of divergent axonal projections from the midbrain raphe nuclei in the rat. J. comp. Neurol. 243, 363-380.
21. Jacobs B. L. and Azmitia E. C. (1992) Structure and function of the brain serotonin system. Physiological Rev. 72, 165-229.
22. Jessop D. S., Chowdrey H. S., Larsen P. J. and Lightman S. L. (1992) Substance P: multifunctional peptide in the hypothalamo pituitary system? J. Endocr. 132, 331-337.
23. Kachidian P., Poulal P., Marlieer L. and Privat A. (1991) Immunohistochemical evidence for the co-existence of substance P, thyrotropin-releasing hormone. GABA, methionine-enkephalin, and leucin-enkephalin in the serotonergic neurons of the caudal raphe nuclei: a dual labeling in the rat. J. Neurosci. Res. 30, 521-530.
24. Larsen P. J., Jessop D. S., Patel H., Lightman S. L. and Chowdrey H. S. (1993) Substance P inhibits the release of anterior pituitary adrenocorticotrophin via a central mechanism involving CRF-41 containing neurons in the hypothalamic paraventricular nucleus. J. Neuroendocr. 5, 99-105.
25. Larsen P. J., Møller M. and Mikkelsen J. D. (1991) Efferent projections from the periventricular and medial parvocellular subnuclei of the hypothalamic paraventricular nucleus to circumventricular organs of the rat. A Phaseolus vulgaris leucoagglutinin (PHA-L) tracing study. J. comp. Neurol. 306, 462-479.
26. Leibowitz S. F. (1990) The role of serotonin in eating disorders. Drugs 39, 33-48.
27. Leonhardt H. and Prien H, (1968) Eine weitere Art intraventriculärer kolbenförmiger Axonendigungen aus dem IV Ventrikel des kaninchengehirns. Z. Zettforsch 139, 285-302.
28. Liposits Z. S., Phelix C. and Paull W. K. (1987) Synaptic interaction of serotonergic axons and corticotropin-releasing factor (CRF) synthesizing neurons in the hypothalamic paraventricular nucleus of the rat. A light and electron microscopic immunocytochemical study. Histochemistry 86, 541-549.
29. Ljungdahl A., Hökfelt T. and Nilsson G. (1978) Distribution of substance P-like immunoreactivity in central nervous system of the rat - I. Cell bodies and terminals. Neuroscience 3, 861-943.
30. Lorez H. P. and Richards J. G. (1975) 5-HT nerve terminals in the fourth ventricle of the rat brain: the identification and distribution studied by fluorescence histochemistry and electon microscopy. Cell Tiss. Res. 165, 37-48.
31. Luiten P. G. M. and Ter Horst G. J. (1986) Pathways for the regulation hormone release in feeding and agonistic behavior. In Emotion (ed. Oomure Y.), pp. 369-380. Karger, Basel.
32. Mitchell J. A. and Card J. P. (1978) Supraependymal neurons overlying the periventricular region of the third ventricle of the guinea pig: a correlative scanning-transmission electron microscopy study. Anat. Rec. 192, 441-458.
33. Moore R. Y., Halaris A. E. and Jones B. E. (1978) Serotonin neurons of the midbrain raphe: ascending projections. J. comp. Neurol. 180, 417-438.
34. Nash J. F., Meltzer H. Y. and Gudelsky G. A. (1988) Elevation of serum prolactin and corticosterone concentrations in the rat after the administration of 3,4-methylenedioxymethamphetamine. J. Pharmac. exp. Ther. 245, 873-879.
35. Paxinos G. and Watson C. (1986) The Rat Brain in Stereotaxic Coordinates. Academic Press, Sydney.
36. Petrov T., Krukoff T. L. and Jhamandas J. H. (1992) The hypothalamic paraventricular and lateral parabrachial nuclei receive collaterals from raphe nucleus neurons: a combined double retrograde and immunocytochemical study. J. comp. Neurol. 318, 18-26.
37. Ribas J. L. (1977) Morphological evidence for a possible functional role of supra-ependymal nerves on ependyma. Brain Res. 125, 362-368.
38. Saphier D. and Feldman S. (1989) Paraventricular nucleus neuronal responses following electrical stimulation of the midbrain dorsal raphe. Exp. Brain Res. 78, 407-414.
39. Saphier D., Welch J. E., Farrar G. E., Nguyen N. Q., Aguado F., Thaller T. R. and Knight D. S. (1994) Interactions between serotonin, thyrotropin-releasing hormone, and substance P in the CNS regulation of adrenocortical secretion. Psychoneuroendocrinology 19, 779-797.
40. Sawchenko P. E., Imaki T. and Vale W. (1992) Co-localization of neuroactive substances in the endocrine hypothalamus. In Functional Anatomy of the Neuroendocrine Hypothalamus (eds Chadwick D. J. and Marsh J.), Vol. Ciba Foundation Symposium 168, pp. 16-53. Wiley, Chichester.
41. Sawchenko P. E. and Swanson L. W. (1983) The organization of forebrain afferents to the paraventricular and supraoptic nuclei of the rat. J. comp. Neurol. 218, 121-144.
42. Sawchenko P. E., Swanson L. W., Steinbusch H. W. M. and Verhofstad A. A. J. (1983) The distribution and cells of origin of serotonergic inputs to the paraventricular and supraoptic nuclei of the rat. Brain Res. 277, 355-360.
43. Sawchenko P. E., Swanson L. W. and Vale W. W. (1984) Co-expression of corticotropin-releasing factor and vasopressin immunoreactivities in parvocellular neurosecretory neurons in the hypothalamus of adrenalectomized rats. Proc. natn. Acad. Sci. 81, 1883-1887.
44. Saydoff J. A., Carnes M. and Brownfield M. S. (1993) The role of serotonergic neurons in intravenous hypertonic saline-induced secretion of vasopressin, oxytocin, and ACTH. Brain Res. Bull. 32, 567-572.
45. Schmued L. C. and Fallon J. H. (1986) Fluoro-Gold: a new fluorescent retrograde axonal tracer with numerous unique properties. Brain Res. 377, 147-154.
46. Steinbusch H. W. M. (1984) Serotonin-immunoreactive neurons and their projections in the CNS. In Classical Transmitters and Transmitter Receptors in the CNS, Part II (eds Boj̈rklund, A., Hökfelt T. and Kuhar M. J.), Vol. 3. Elsevier, Amsterdam.
47. Steinbusch H. W. M. and Nieuwenhuys R. (1983) The raphe nuclei of the rat brainstem: a cytoarchitectonic and immunohistochemical study. In Chemical Neuroanatomy (ed. Emson P. C.), pp. 131-207. Raven Press, New York.
48. Swanson L. W. (1987) The hypothalamus. In Handbook of Chemical Neuroanatomy (eds Björklund A., Hökfelt T. and Swanson L. W.), Vol. 5, pp. 1-124. Elsevier, Amsterdam.
49. Swanson L. W. and Kuypers H. G. J. M. (1980) The paraventricular nucleus of the hypothalamus: cytoarchitectonic subdivisions and organization of projections to the pituitary, dorsal vagal complex, and spinal cord as demonstrated by retrograde fluorescence double-labeling methods. J. comp. Neurol. 194, 555-569.
50. Swanson L. W. and Sawchenko P. E. (1986) Regulation of multiple peptides in CRF parvocellular neurosecretory neurons: implications for the stress response. Prog. Brain Res. 68, 169-190.
51. Ter Horst G. J. and Luiten P. G. M. (1987) Phaseolus vulgaris leucoagglutinin tracing of intrahypothalamic connections of the lateral, ventromedial, dorsomedial and paraventricular hypothalamic nuclei in the rat. Brain Res. Bull. 18, 191-203.
52. Torigoe Y., Blanks R. H. I. and Precht W. (1986) Anatomical studies on the nucleus reticularis tegmenti pontis in the pigmented rat - I. Cytoarchitecture, topography, and cerebral cortical afferents. J. comp. Neurol. 243, 71-87.
53. Törk I. (1985) Raphe nuclei and serotonin containing systems. In The Rat Nervous System (ed. Paxinos G.), Vol. 2, pp. 43-78. Academic Press, Sydney.
54. Uhl G. R., Goodman R. R., Kuhar M. J., Childers S. R. and Snyder S. H. (1979) Immunohistochemical mapping of enkephalin containing cell bodies, fibers and nerve terminals in the brain stem of the rat. Brain Res. 166, 75-94.
55. Van de Kar L. D. (1991) Neuroendocrine pharmacology of serotonergic (5-HT) neurons. A. Rev. Pharmac. Toxic. 289-320.
56. Van de Kar L. D., Karteszi M., Bethea C. L. and Ganong W. F. (1985) Serotonergic stimulation of prolactin and corticosterone secretion is ediated by different pathways from the mediobasal hypothalamus. Neuroendocrinology 41, 380-384.
57. Van de Kar L. D., Wilkinson C. W., Skrobik Y., Browfield M. S. and S. F. G. (1982) Evidence that serotonergic neurons in the dorsal raphe nucleus exert a stimulatory effect on the secretion of renin but not of corticosterone. Brain Res. 235, 233-243.
58. Vertes R. P. (1991) A PHA-L analysis of ascending projections of the dorsal raphe nucleus in the rat. J. comp. Neurol. 313, 643-668.
59. Vertes R. P. and Martin G. F. (1988) Autoradiographic analysis of ascending projections from the pontine and mesencephalic reticular formation and the median raphe nucleus in the rat. J. comp. Neurol. 275, 511-541.
60. 1A receptors inhibit adrenocortical secretion. Neuroendocrinology 57, 272-281.
61. Wiklund L., Leger L. and Persson M. (1981) Monoamine cell distribution in the cat brain. A fluorescence histochemical study with quantification of indolaminergic and locus coeruleus cell groups. J. comp. Neurol. 203, 613-647.
62. Wilkinson L. O. and Jacobs B. L. (1988) Lack of response of serotonergic neurons in the dorsal raphe nucleus of freely moving cats to stressful stimuli. Exp. Neurol. 101, 445-457.