A next generation, pilot-scale continuous sterilization system for fermentation media

Bioprocess and Biosystems Engineering

Volumn 28, Issue 6, 2006, Pages 351-378

  Junker, B ^a   Lester, M ^a   Brix, T ^a   Wong, D ^a   Nuechterlein, J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Continuous sterilizer; High temperature short time; Pilot scale; Spiral heat exchanger; Start up

Indexed keywords

BIOCONVERSION; ENZYMES; FERMENTATION; HEAT EXCHANGERS; INDUSTRIAL RESEARCH; METABOLITES; RETROFITTING;

CONTINUOUS STERILIZER; HIGH TEMPERATURE SHORT TIME; PILOT SCALE; SPIRAL HEAT EXCHANGER; START-UP;

STERILIZATION (CLEANING);

ARTICLE; BIOTRANSFORMATION; CULTURE TECHNIQUE; ENZYME SYNTHESIS; FERMENTATION; FERMENTATION MEDIUM; HEAT EXCHANGE; HIGH TEMPERATURE; INSTRUMENTATION; MATHEMATICAL MODEL; ONLINE ANALYSIS; PRESSURE; PRIORITY JOURNAL; STERILIZATION SYSTEM; BIOREACTOR; CELL FRACTIONATION; COMPUTER AIDED DESIGN; CULTURE MEDIUM; EQUIPMENT; EQUIPMENT DESIGN; ESCHERICHIA COLI; EVALUATION; INSTRUMENT STERILIZATION; ISOLATION AND PURIFICATION; METHODOLOGY; PILOT STUDY;

BIOREACTORS; CELL CULTURE TECHNIQUES; CELL FRACTIONATION; COMPUTER-AIDED DESIGN; CULTURE MEDIA; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; ESCHERICHIA COLI; FERMENTATION; PILOT PROJECTS; STERILIZATION;

EID: 33745934832     PISSN: 16157591     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00449-005-0041-0     Document Type: Article

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