-
1
-
-
8344242220
-
Autophagy in health and disease: A double-edged sword
-
Shintani T, Klionsky DJ. Autophagy in health and disease: A double-edged sword. Science 2004; 306:990-5.
-
(2004)
Science
, vol.306
, pp. 990-995
-
-
Shintani, T.1
Klionsky, D.J.2
-
2
-
-
0036566266
-
Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy
-
Ravikumar B, Duden R, Rubinsztein DC. Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy. Hum Mol Genet 2002; 11:1107-17.
-
(2002)
Hum Mol Genet
, vol.11
, pp. 1107-1117
-
-
Ravikumar, B.1
Duden, R.2
Rubinsztein, D.C.3
-
3
-
-
33644540193
-
Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway
-
Yamamoto A, Cremona ML, Rothman JE. Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway. J Cell Biol 2006; 172:719-31.
-
(2006)
J Cell Biol
, vol.172
, pp. 719-731
-
-
Yamamoto, A.1
Cremona, M.L.2
Rothman, J.E.3
-
4
-
-
0141891215
-
Pathogenesis of polyglutamine disorders: Aggregation revisited
-
Michalik A, Van Broeckhoven C. Pathogenesis of polyglutamine disorders: Aggregation revisited. Hum Mol Genet 2003; 12:R173-86.
-
(2003)
Hum Mol Genet
, vol.12
-
-
Michalik, A.1
Van Broeckhoven, C.2
-
5
-
-
20244378556
-
RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model
-
Harper SQ, Staber PD, He X, Eliason SL, Martins IH, Mao Q, Yang L, Kotin RM, Paulson HL, Davidson BL. RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model. Proc Natl Acad Sci USA 2005; 102:5820-5.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 5820-5825
-
-
Harper, S.Q.1
Staber, P.D.2
He, X.3
Eliason, S.L.4
Martins, I.H.5
Mao, Q.6
Yang, L.7
Kotin, R.M.8
Paulson, H.L.9
Davidson, B.L.10
-
6
-
-
13244258435
-
Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation
-
Bennett EJ, Bence NF, Jayakumar R, Kopito RR. Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation. Mol Cell 2005; 17:351-65.
-
(2005)
Mol Cell
, vol.17
, pp. 351-365
-
-
Bennett, E.J.1
Bence, N.F.2
Jayakumar, R.3
Kopito, R.R.4
-
7
-
-
24944482408
-
Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation
-
Iwata A, Christianson JC, Bucci M, Ellerby LM, Nukina N, Forno LS, Kopito RR. Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation. Proc Natl Acad Sci USA 2005; 102:13135-40.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 13135-13140
-
-
Iwata, A.1
Christianson, J.C.2
Bucci, M.3
Ellerby, L.M.4
Nukina, N.5
Forno, L.S.6
Kopito, R.R.7
-
8
-
-
2642586352
-
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
-
Ravikumar B, Vacher C, Berger Z, Davies JE, Luo S, Oroz LG, Scaravilli F, Easton DF, Duden R, O'Kane CJ, Rubinsztein DC. Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet 2004; 36:585-95.
-
(2004)
Nat Genet
, vol.36
, pp. 585-595
-
-
Ravikumar, B.1
Vacher, C.2
Berger, Z.3
Davies, J.E.4
Luo, S.5
Oroz, L.G.6
Scaravilli, F.7
Easton, D.F.8
Duden, R.9
O'Kane, C.J.10
Rubinsztein, D.C.11
-
9
-
-
1542289063
-
Amino acids and insulin control autophagic proteolysis through different signaling pathways in relation to mTOR in isolated rat hepatocytes
-
Kanazawa T, Taneike I, Akaishi R, Yoshizawa F, Furuya N, Fujimura S, Kadowaki M. Amino acids and insulin control autophagic proteolysis through different signaling pathways in relation to mTOR in isolated rat hepatocytes. J Biol Chem 2004; 279:8452-9.
-
(2004)
J Biol Chem
, vol.279
, pp. 8452-8459
-
-
Kanazawa, T.1
Taneike, I.2
Akaishi, R.3
Yoshizawa, F.4
Furuya, N.5
Fujimura, S.6
Kadowaki, M.7
-
10
-
-
33646147140
-
Role of Rab5 in insulin receptor-mediated endocytosis and signaling
-
In press
-
Hunker CM, Kruk I, Hall J, Giambini H, Veisaga ML, Barbieri MA. Role of Rab5 in insulin receptor-mediated endocytosis and signaling. Arch Biochem Biophys 2006; In press.
-
(2006)
Arch Biochem Biophys
-
-
Hunker, C.M.1
Kruk, I.2
Hall, J.3
Giambini, H.4
Veisaga, M.L.5
Barbieri, M.A.6
-
11
-
-
0035818483
-
Insulin can regulate GLUT4 internalization by signaling to Rab5 and the motor protein dynein
-
Huang J, Imamura T, Olefsky JM. Insulin can regulate GLUT4 internalization by signaling to Rab5 and the motor protein dynein. Proc Natl Acad Sci USA 2001; 98:13084-9.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 13084-13089
-
-
Huang, J.1
Imamura, T.2
Olefsky, J.M.3
-
12
-
-
23944437499
-
An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway
-
Shin HW, Hayashi M, Christoforidis S, Lacas-Gervais S, Hoepfner S, Wenk MR, Modregger J, Uttenweiler-Joseph S, Wilm M, Nystuen A, Frankel WN, Solimena M, De Camilli P, Zerial M. An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway. J Cell Biol 2005; 170:607-18.
-
(2005)
J Cell Biol
, vol.170
, pp. 607-618
-
-
Shin, H.W.1
Hayashi, M.2
Christoforidis, S.3
Lacas-Gervais, S.4
Hoepfner, S.5
Wenk, M.R.6
Modregger, J.7
Uttenweiler-Joseph, S.8
Wilm, M.9
Nystuen, A.10
Frankel, W.N.11
Solimena, M.12
De Camilli, P.13
Zerial, M.14
-
13
-
-
0029940388
-
Insulin induces a change in Rab5 subcellular localization in adipocytes independently of phosphatidylinositol 3-kinase activation
-
Cormont M, Van Obberghen E, Zerial M, Le Marchand-Brustel Y. Insulin induces a change in Rab5 subcellular localization in adipocytes independently of phosphatidylinositol 3-kinase activation. Endocrinology 1996; 137:3408-15.
-
(1996)
Endocrinology
, vol.137
, pp. 3408-3415
-
-
Cormont, M.1
Van Obberghen, E.2
Zerial, M.3
Le Marchand-Brustel, Y.4
-
14
-
-
0042466604
-
Insulin induces phosphatidylinositol-3-phosphate formation through TC10 activation
-
Maffucci T, Brancaccio A, Piccolo E, Stein RC, Falasca M. Insulin induces phosphatidylinositol-3-phosphate formation through TC10 activation. EMBO J 2003; 22:4178-89.
-
(2003)
EMBO J
, vol.22
, pp. 4178-4189
-
-
Maffucci, T.1
Brancaccio, A.2
Piccolo, E.3
Stein, R.C.4
Falasca, M.5
-
15
-
-
29244462334
-
Insulin signaling and the regulation of glucose transport
-
Chang L, Chiang SH, Saltiel AR, Insulin signaling and the regulation of glucose transport. Mol Med 2004; 10:65-71.
-
(2004)
Mol Med
, vol.10
, pp. 65-71
-
-
Chang, L.1
Chiang, S.H.2
Saltiel, A.R.3
-
16
-
-
10644251864
-
Insulin substrates 1 and 2 are corequired for activation of atypical protein kinase C and Cbl-dependent phosphatidylinositol 3-kinase during insulin action in immortalized brown adipocytes
-
Miura A, Sajan MP, Standaert ML, Bandyopadhyay G, Kahn CR, Farese RV. Insulin substrates 1 and 2 are corequired for activation of atypical protein kinase C and Cbl-dependent phosphatidylinositol 3-kinase during insulin action in immortalized brown adipocytes. Biochemistry 2004; 43:15503-9.
-
(2004)
Biochemistry
, vol.43
, pp. 15503-15509
-
-
Miura, A.1
Sajan, M.P.2
Standaert, M.L.3
Bandyopadhyay, G.4
Kahn, C.R.5
Farese, R.V.6
-
17
-
-
26444575415
-
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase
-
Nobukuni T, Joaquin M, Roccio M, Dann SG, Kim SY, Gulati P, Byfield MP, Backer JM, Natt F, Bos JL, Zwartkruis FJ, Thomas G. Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Proc Natl Acad Sci USA 2005; 102:14238-43.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 14238-14243
-
-
Nobukuni, T.1
Joaquin, M.2
Roccio, M.3
Dann, S.G.4
Kim, S.Y.5
Gulati, P.6
Byfield, M.P.7
Backer, J.M.8
Natt, F.9
Bos, J.L.10
Zwartkruis, F.J.11
Thomas, G.12
-
18
-
-
25444457577
-
hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase
-
Byfield MP, Murray JT, Backer JM. hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase. J Biol Chem 2005; 280:33076-82.
-
(2005)
J Biol Chem
, vol.280
, pp. 33076-33082
-
-
Byfield, M.P.1
Murray, J.T.2
Backer, J.M.3
-
19
-
-
33644514920
-
Tissue-specific roles of IRS proteins in insulin signaling and glucose transport
-
Thirone AC, Huang C, Klip A. Tissue-specific roles of IRS proteins in insulin signaling and glucose transport. Trends Endocrinol Metab 2006; 17:72-8.
-
(2006)
Trends Endocrinol Metab
, vol.17
, pp. 72-78
-
-
Thirone, A.C.1
Huang, C.2
Klip, A.3
-
20
-
-
21444460644
-
Differential contribution of insulin receptor substrates 1 versus 2 to insulin signaling and glucose uptake in 16 myotubes
-
Huang C, Thirone AC, Huang X, Klip A. Differential contribution of insulin receptor substrates 1 versus 2 to insulin signaling and glucose uptake in 16 myotubes. J Biol Chem 2005; 280:19426-35.
-
(2005)
J Biol Chem
, vol.280
, pp. 19426-19435
-
-
Huang, C.1
Thirone, A.C.2
Huang, X.3
Klip, A.4
-
21
-
-
0242499488
-
Localization of phosphorylated ERK/MAP kinases to mitochondria and autophagosomes in Lewy body diseases
-
Zhu JH, Guo F, Shelburne J, Watkins S, Chu CT. Localization of phosphorylated ERK/MAP kinases to mitochondria and autophagosomes in Lewy body diseases. Brain Pathol 2003; 13:473-81.
-
(2003)
Brain Pathol
, vol.13
, pp. 473-481
-
-
Zhu, J.H.1
Guo, F.2
Shelburne, J.3
Watkins, S.4
Chu, C.T.5
-
22
-
-
0043127453
-
Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation
-
Schubert M, Brazil DP, Burks DJ, Kushner JA, Ye J, Flint CL, Farhang-Fallah J, Dikkes P, Warot XM, Rio C, Corfas G, White MF. Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J Neurosci 2003; 23:7084-92.
-
(2003)
J Neurosci
, vol.23
, pp. 7084-7092
-
-
Schubert, M.1
Brazil, D.P.2
Burks, D.J.3
Kushner, J.A.4
Ye, J.5
Flint, C.L.6
Farhang-Fallah, J.7
Dikkes, P.8
Warot, X.M.9
Rio, C.10
Corfas, G.11
White, M.F.12
-
23
-
-
16044373842
-
Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
-
Mangiarini L, Sathasivam K, Seller M, Cozens B, Harper A, Hetherington C, Lawton M, Trottier Y, Lehrach H, Davies SW, Bates GP. Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell 1996; 87:493-506.
-
(1996)
Cell
, vol.87
, pp. 493-506
-
-
Mangiarini, L.1
Sathasivam, K.2
Seller, M.3
Cozens, B.4
Harper, A.5
Hetherington, C.6
Lawton, M.7
Trottier, Y.8
Lehrach, H.9
Davies, S.W.10
Bates, G.P.11
-
24
-
-
33744916798
-
Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1
-
In press
-
Shibata M, Lu T, Furuya T, Degterev A, Mizushima N, Yoshimori T, Macdonald M, Yankner B, Yuan J. Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. J Biol Chem 2006; In press.
-
(2006)
J Biol Chem
-
-
Shibata, M.1
Lu, T.2
Furuya, T.3
Degterev, A.4
Mizushima, N.5
Yoshimori, T.6
Macdonald, M.7
Yankner, B.8
Yuan, J.9
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