Mutation of herpesvirus thymidine kinase to generate ganciclovir-specific kinases for use in cancer gene therapies

Protein Engineering

Volumn 15, Issue 11, 2002, Pages 903-911

  Mercer, Kelly E ^a   Ahn, Christina E ^a   Coke, Amanda ^a   Compadre, Cesar M ^b   Drake, Richard R ^a  

^a EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Ganciclovir; Gene therapy; Thymidine; Thymidine kinase; Thymidylate kinase

Indexed keywords

ALANINE; GANCICLOVIR; GLYCINE; NUCLEOSIDE; PHOSPHOTRANSFERASE; PYRIMIDINE DERIVATIVE; THYMIDINE; THYMIDINE KINASE;

ARTICLE; BINDING SITE; CANCER GENETICS; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME SPECIFICITY; ENZYME SUBSTRATE; GENE MUTATION; GENE THERAPY; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; METABOLISM; MOLECULAR MODEL; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN FOLDING; PROTEIN FUNCTION; TUMOR CELL;

HERPESVIRIDAE; HUMAN HERPESVIRUS 1; SIMPLEXVIRUS;

EID: 0036878164     PISSN: 02692139     EISSN: None     Source Type: Journal    
DOI: 10.1093/protein/15.11.903     Document Type: Article

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