Selection of HSV-1 TK gene-transfected murine mammary carcinoma cells resistant to (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and ganciclovir (GCV)

Gene Therapy

Volumn 7, Issue 18, 2000, Pages 1543-1552

  Degreve, B ^a   De Clercq, E ^a   Balzarini, J ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Antiherpetic nucleoside analogues; BVDU; GCV; Gene therapy; HSV 1 thymidine kinase; Resistance

Indexed keywords

5 (2 BROMOVINYL) 2' DEOXYCYTIDINE; 5 (2 BROMOVINYL) 2' DEOXYURIDINE; 5 (2 IODOVINYL) 2' DEOXYURIDINE; 5 ETHYNYL 4 IMIDAZOLECARBOXAMIDE 1 RIBOSIDE; ACICLOVIR; AZACITIDINE; BUCICLOVIR; FLOXURIDINE; FLUOROURACIL; GANCICLOVIR; GEMCITABINE; HYDROXYUREA; MESSENGER RNA; METHOTREXATE; NUCLEOSIDE ANALOG; PENCICLOVIR; THYMIDINE KINASE;

ANIMAL CELL; ARTICLE; BREAST CARCINOMA; CARCINOMA CELL; CELL CULTURE; CELL SELECTION; CELL STRAIN; CONTROLLED STUDY; DRUG EXPOSURE; DRUG RESISTANCE; DRUG SENSITIVITY; DRUG STRUCTURE; ENZYME ACTIVITY; GENE DELETION; GENETIC TRANSFECTION; HERPES SIMPLEX VIRUS 1; METHYLATION; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING; VIRUS GENE;

ANIMALIA; DNA VIRUSES; HERPES; HUMAN HERPESVIRUS 1; MURINAE;

EID: 0033780917     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301278     Document Type: Article

References (28)

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2. Murine mammary FM3A carcinoma cells transformed with the herpes simplex virus type 1 thymidine kinase gene are highly sensitive to the growth-inhibitory properties of (E)-5-(2-bromovinyl)-2'-deoxyuridine and related compounds
3. Highly selective cytostatic activity of (E)-5-(2-bromovinyl) -2'-deoxyuridine derivatives for murine mammary (FM3A) carcinoma cells transformed with the herpes simplex virus type 1 thymidine kinase gene
4. Differential mechanism of cytostatic effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine, 9-(1,3-dihydroxy -2-propoxymethyl)guanine, and other antiherpetic drugs on tumor cells virus type 1 or type 2
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9. -) tumor cell lines to the cell growth inhibitory effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU) and related compounds
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28. Deoxycytidine kinase from calf thymus