Application of pharmacodynamic modeling for designing time-variant dosing regimens to overcome nitroglycerin tolerance in experimental heart failure

Pharmaceutical Research

Volumn 14, Issue 9, 1997, Pages 1140-1145

  Bauer, John Anthony ^a,b   Balthasar, Joseph P ^a,c   Fung, Ho Leung ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c UNIVERSITY OF UTAH   (United States)

Author keywords

Hemodynamics; Nitrate; Nitroglycerin; Pharmacodynamics; Tolerance

Indexed keywords

GLYCERYL TRINITRATE;

ARTICLE; COMPUTER SIMULATION; DRUG TOLERANCE; HEART FAILURE; HEMODYNAMICS; HUMAN; MODEL; NONHUMAN; PHARMACODYNAMICS; PREDICTION; PRIORITY JOURNAL;

ANIMALS; DISEASE MODELS, ANIMAL; DRUG DELIVERY SYSTEMS; DRUG DESIGN; DRUG TOLERANCE; HEART FAILURE, CONGESTIVE; MODELS, BIOLOGICAL; NITROGLYCERIN; RATS; TIME FACTORS; VASODILATOR AGENTS;

EID: 0030771208     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1012138320003     Document Type: Article

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