Mechanism-based pharmacokinetic-pharmacodynamic modeling of the effects of N6-oyclopentyladenosine analogs on heart rate in rat: Estimation of in vivo operational affinity and efficacy at adenosine A1 receptors

Journal of Pharmacology and Experimental Therapeutics

Volumn 283, Issue 2, 1997, Pages 809-816

  Van Der Graaf, P H ^a   Van Schaick, E A ^a   Mathot R A A ^a   Ijzerman, A P ^a   Danhof, M ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

6 N CYCLOPENTYLADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR AGONIST; ADENOSINE DERIVATIVE; GUANOSINE TRIPHOSPHATE;

ANIMAL TISSUE; ARTICLE; COMPARTMENT MODEL; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG RECEPTOR BINDING; HEART RATE; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ADENOSINE; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; GUANOSINE TRIPHOSPHATE; HEART RATE; MALE; MODELS, BIOLOGICAL; RATS; RATS, WISTAR; RECEPTORS, PURINERGIC P1;

EID: 0030830382     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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