Studies on the role of 5-HT(2C) and 5-HT(2B) receptores in regulating generalized seizure threshold in rodents

European Journal of Pharmacology

Volumn 359, Issue 1, 1998, Pages 33-40

  Upton, Neil ^a   Stean, Tania ^a   Middlemiss, Derek ^a   Blackburn, Tom ^a   Kennett, Guy ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

5 HT(2B) receptor; 5 HT(2C) receptor; BW 723C86; m Chlorophenylpiperazine; SB 206553; Seizure

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; 1 [5 (2 THIENYLMETHOXY) 3 INDOLYL] 2 PROPANAMINE; 1,2,3,5 TETRAHYDRO 5 METHYL 1 (3 PYRIDYLCARBAMOYL)PYRROLO[2,3 F]INDOLE; 5 METHYL 1 (3 PYRIDYLCARBOMOYL) 1,2,3,5 TETRAHYDROPYRROLO[2,3F]INDOLE; INDOLE DERIVATIVE; PENTETRAZOLE; RECEPTOR SUBTYPE; SEROTONIN; SEROTONIN 2B RECEPTOR; SEROTONIN 2C RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; ELECTRIC SHOCK; GRAND MAL SEIZURE; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; SEIZURE THRESHOLD; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; DRUG INTERACTIONS; ELECTRIC STIMULATION; INDOLES; MALE; MICE; PENTYLENETETRAZOLE; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2C; RECEPTORS, SEROTONIN; SEIZURES; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; THIOPHENES;

EID: 0032538536     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00621-9     Document Type: Article

References (26)

1. 2C receptor mutant mice. Nature Genetics. 16:1997;387-390.
2. Browning R.A., Hoffman W.E., Simonton R.L. Changes in seizure susceptibility after intracerebral treatment with 5,7-dihydroxytryptamine: role of serotonergic neurones. Ann. New York Acad. Sci. 305:1978;437-456.
3. Buterbaugh C.G. Effects of drugs modifying central serotonergic function on the response of extensor and non extensor rats to maximal electroshock. Life Sci. 23:1978;2393-2904.
4. Dailey J.W., Yan Q.S., Mishra P.K., Burger R.L., Jobe P.C. Effects of fluoxetine on convulsions and brain serotonin as detected by microdialysis in genetically epilepsy-prone rats. J. Pharmacol. Exp. Ther. 260:1992;533-540.
5. De La Torre J.C., Kawanaga H.M., Mullan S. Seizure susceptibility after manipulation of brain serotonin. Arch. Int. Pharmacodyn. Ther. 188:1970;298-304.
6. Hiramatsu M.K., Ogawa K., Kabuto H., Mori A. Reduced uptake and release of 5-hydroxytryptamine and taurine in the cerebral cortex of epileptic El mice. Epilepsy Res. 1:1987;40-44.
7. 1C receptors and their therapeutic relevance. Curr. Opin. Invest. Drugs. 2:1993;317-362.
8. 2B receptor agonist, BW-723C86, on three rat models of anxiety. Br. J. Pharmacol. 117:1996;1443-1448.
9. 2B receptor antagonist with anxiolytic-like properties. Br. J. Pharmacol. 117:1996;427-434.
10. 2B receptor agonist, causes hyperphagia and reduced grooming in rats. Neuropharmacology. 36:1997;233-239.
11. 2C receptor antagonist. Neuropharmacology. 36:1997;609-620.
12. Kilian M., Frey H.H. Central monoamines and convulsive thresholds in mice and rats. Neuropharmacology. 12:1973;681-692.
13. Kimball A.W., Burnett W.T., Doherty D.G. Chemical protection against ionising radiation: I. Sampling methods for screening compounds in radiation protection studies with mice. Radiation Res. 7:1957;1-12.
14. Litchfield J.T., Wilcoxon F. A simplified method of evaluating dose-effect experiments. J. Pharmacol. Exp. Ther. 96:1949;99-113.
15. Löscher W., Schmidt D. Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations. Epilepsy Res. 2:1988;145-181.
16. Löscher W., Pagliusi S.R., Müller F. L-5-Hydroxytryptophan. Correlation between anticonvulsant effect and increases in levels of 5-hydroxyindoles in plasma and brain. Neuropharmacology. 23:1984;1041-1048.
17. Piredda S.G., Woodhead J.H., Swinyard E.A. Effect of stimulus intensity on the profile of anticonvulsant activity of phenytoin, ethosuximide and valproate. J. Pharmacol. Exp. Ther. 232:1985;741-745.
18. Prendiville S., Gale K. Anticonvulsant effect of systemic fluoxetine on focally-evoked limbic motor seizures in rats. Epilepsia. 34:1993;381-384.
19. Przegalinski, E., 1985. Monoamines and the pathophysiology of seizure disorders. In: Frey, H.H., Janz, D. (Eds.), Handbook of Experimental Pharmacology. Springer Verlag, Berlin, 74, 101-137.
20. Przegalinski E., Baran L., Siwanowicz J. Role of 5-hydroxytryptamine receptor subtypes in the 1-[3-(trifluoromethyl)phenyl]piperazine-induced increase in threshold for maximal electroconvulsions in mice. Epilepsia. 35:1994;889-894.
21. Statnick M.A., Maring-Smith M.L., Clough R.W., Wang C., Dailey J.W., Jobe P.C., Browning R.A. Effects of 5,7-dihydroxytryptamine on audiogenic seizures in genetically epilepsy-prone rats. Life Sci. 59:1996;1763-1771.
22. 2C serotonin receptors. Nature. 374:1995;542-546.
23. Upton N. Mechanisms of action of new antiepileptic drugs: rational design and serendipitous findings. Trends Pharmacol. Sci. 15:1994;456-463.
24. Upton N., Blackburn T.P., Campbell C.A., Cooper D., Evans M.L., Herdon H.J., King P.D., Ray A.M., Stean T.O., Chan W.N., Evans J.M., Thompson M. Profile of SB-204269, a mechanistically novel anticonvulsant drug, in rat models of focal and generalized epileptic seizures. Br. J. Pharmacol. 121:1997;1679-1686.
25. Wada Y., Shiraishi J., Nakamura M., Koshino Y. Role of serotonin receptor subtypes in the development of amygdaloid kindling in rats. Brain Res. 747:1997;338-342.
26. Yan Q.S., Jobe P.C., Cheong J.H., Ko K.H., Dailey J.W. Role of serotonin in the anticonvulsant effect of fluoxetine in genetically epilepsy prone rats. Naunyn-Schmiedeberg's Arch. Pharmacol. 350:1994;149-152.