Synthesis and 5-HT1A/5-HT2A receptor activity of new N-[3-(4-phenylpiperazin-1-yl-propyl] derivatives of 3-spiro-cyclohexanepyrrolidine-2, 5-dione and 3-spiro-β-tetralonepyrro-lidine-2, 5-dione

Polish Journal of Pharmacology

Volumn 55, Issue 4, 2003, Pages 553-557

  Obniska, Jolanta ^a   Pawłowski, Maciej ^a   Kołaczkowski, Marcin ^a   Czopek, Anna ^a   Duszyńska, Beata ^b   Kłoszinska, Aleksandra ^b   Tatarczyńska, Ewa ^b   Chojnacka Wójcik, Ewa ^b  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^b INSTITUTE OF PHARMACOLOGY   (Poland)

Author keywords

3 spiro tetralone pyrrolidine 2; 3 spiro cyclohexanepyrrolidine 2; 5 dione; 5 HT1A and 5 HT2A receptor affinity; Arylpiperazines; Spirosuccinimides; Structure activity relationship

Indexed keywords

3 SPIRO BETA TETRALONEPYRROLIDINE 2,5 DIONE DERIVATIVE; 3 SPIROCYCLOHEXANEPYRROLIDINE 2,5 DIONE DERIVATIVE; AMIDE; ANXIOLYTIC AGENT; CYCLOHEXANE; PIPERAZINE DERIVATIVE; PYRROLIDINE DERIVATIVE; SEROTONIN 1A RECEPTOR; SEROTONIN 2A ANTAGONIST; SEROTONIN 2A RECEPTOR; UNCLASSIFIED DRUG; 3 SPIRO BETA TETRALONEPYRROLIDINE 2,5 DIONE; 3 SPIRO CYCLO HEXANEPYRROLIDINE 2,5 DIONE; 3-SPIRO-BETA-TETRALONEPYRROLIDINE-2,5-DIONE; 3-SPIRO-CYCLO-HEXANEPYRROLIDINE-2,5-DIONE; SEROTONIN RECEPTOR AFFECTING AGENT; SPIRO COMPOUND;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG ANALYSIS; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; MALE; MOUSE; NONHUMAN; PROTEIN FUNCTION; ANIMAL; ANIMAL BEHAVIOR; BINDING COMPETITION; CHEMICAL STRUCTURE; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECT; METABOLISM; RADIOASSAY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; BEHAVIOR, ANIMAL; BINDING, COMPETITIVE; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRROLIDINES; RADIOLIGAND ASSAY; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTOR, SEROTONIN, 5-HT2A; SEROTONIN AGENTS; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 3342910427     PISSN: 12306002     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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