Postsynaptic 5-HT 1B receptors modulate electroshock-induced generalised seizures in rats

British Journal of Pharmacology

Volumn 144, Issue 5, 2005, Pages 628-635

  Stean, Tania O ^a   Atkins, Alan R ^a   Heidbreder, Christian A ^a   Quinn, Leann P ^a   Trail, Brenda K ^a   Upton, Neil ^a  

^a GSK   (Italy)

Author keywords

Electroshock; Generalised seizures; Postsynaptic 5 HT 1B receptors; Rat; RU 24969; SB 224289; SKF 99101

Indexed keywords

2,3,6,7 TETRAHYDRO 1' METHYL 5 [[2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL) 4 BIPHENYLYL]CARBONYL]SPIRO[FURO[2,3 F]INDOLE 3,4' PIPERIDINE]; 3 (2 DIMETHYLAMINOETHYL) 4 CHLORO 5 PROPOXYINDOLE; 5 METHOXY 3 (1,2,3,6 TETRAHYDRO 4 PYRIDYL) 1H INDOLE; FENCLONINE; METERGOLINE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; N [4 METHOXY 3 (4 METHYL 1 PIPERAZINYL)PHENYL] 2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL)[1,1' BIPHENYL] 4 CARBOXAMIDE; PINDOLOL; SEROTONIN; SEROTONIN 1A RECEPTOR; SEROTONIN 1B ANTAGONIST; SEROTONIN 1B RECEPTOR; SEROTONIN 1D ANTAGONIST; SEROTONIN 1D RECEPTOR; SEROTONIN AGONIST; UNCLASSIFIED DRUG; 5 METHOXY 3 (1,2,3,6 TETRAHYDRO 4 PYRIDINYL)1H INDOLE; 5-METHOXY 3-(1,2,3,6-TETRAHYDRO-4-PYRIDINYL)1H INDOLE; INDOLE DERIVATIVE; PIPERIDONE DERIVATIVE; SB 22489G; SEROTONIN ANTAGONIST; SPIRO COMPOUND;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFECT; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; ELECTRIC SHOCK; GRAND MAL SEIZURE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SEIZURE THRESHOLD; ANIMAL; DRUG ANTAGONISM; DRUG POTENTIATION; SEIZURE; SPRAGUE DAWLEY RAT;

ANIMALS; ELECTROSHOCK; INDOLES; MALE; PIPERIDONES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTOR, SEROTONIN, 5-HT1B; RECEPTOR, SEROTONIN, 5-HT1D; SEIZURES; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SPIRO COMPOUNDS;

EID: 15944387046     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706027     Document Type: Article

References (38)

1. ARTIGAS, F., CELEDA, P., LARUELLE, M. & ADELL, A. (2001). How does pindolol improve antidepresant action? TIPS, 22, 224-228.
2. 2+-induced epileptiform activity in the subiculum of rats studied in vitro. Psych. Res., 737, 1-2.
3. BLACKWOOD, D.H., KAPOOR, V. & MARTIN, M.J. (1981). Regional changes in cerebral glucose utilization associated with amygdaloid kindling and electroshock in the rat. Brain Res., 224, 204-208.
4. BURLEY, E.S. & FERRENDELLI, J.A. (1984). Regulatory effects of neurotransmitters on electroshock and pentylenetetrazol seizures. Fed. Proc., 43, 2521-2524.
5. CHOPIN, P., MORET, C. & BRILEY, M. (1994). Neuropharmacology of 5-hydroxytryptamine1B/1D receptor ligands. Pharmac. Ther., 62, 385-405.
6. 1A antagonist, WAY 100635. Psychopharmacologia, 132, 35-43.
7. 2+. Eur. J. Pharmacol., 328, 153-162.
8. DELEAN, A., MUNSON, P.J. & RODBARD, D. (1978). Simultaneous families of sigmiodal curves: application to bioassay, radioligand assay and physiological dose-response curves. Am. J. Physiol., 235, E97-E102.
9. 1A receptor antagonist. Behav. Brain Res., 73, 337-353.
10. 1B receptor inverse agonist 1′-methyl- 5[[2′-methyl-4′-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl] carbonyl-2,3,6,7-tetrahydrospiro[furo[2,3-F]indole-3,4′-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo. J. Med. Chem., 41, 1218-1235.
11. 1B receptors causes hypothermia in the guinea pig. Eur. J. Pharmacol., 331, 169-174.
12. 1D receptors mediate SKF 99101H-induced hypothermia in the guinea pig. J. Psychopharmacol., 9, 234-241.
13. HIRAMATSU, M., OGAWA, K., KABUTO, H. & MORI, A. (1987). Reduced uptake and release of 5-hydroxytryptamine and taurine in the cerebral cortex of epileptic E1 mice. Epilep. res., 1, 40-45.
14. HJORTH, S. & CARLSSON, A. (1986). Is pindolol a mixed agonist-antagonist at central serotonin (5-HT) receptors? Eur. J. Pharmacol., 129, 131-138.
15. HOLE, S., FUXE, K. & JONSSON, G. (1976). Behavioural effects of 5, 7-dihydroxytryptamine lesions of ascending 5-hydroxytryptamine pathways. Brain Res., 107, 385-399.
16. HOYER, D. (1989). 5-Hydroxytryptamine receptors and effector coupling mechanisms in peripheral tissues. In: The Peripheral Actions of 5-Hydroxytryptamine, ed. Fozard, J. pp 72-99. Oxford: Oxford University Press.
17. 2c receptor antagonist. Neuropharmacology, 36, 609-620.
18. KHANNA, N., RAY, A., ALKONDON, M. & SEN, P. (1989). Effect of beta-adrenoceptor antagonists and some related drugs on maximal electroshock seizures in mice. Indian J. Exp. Biol., 27, 128-130.
19. 1B-receptor stimulation. Brain Res., 692, 111-117.
20. KIMBALL, A.W., BURNETT, W.T. & DOHERTY, D.G. (1957). Chemical protection against ionising radiation: I. Sampling methods of screening compounds in radiation protection studies in mice. Radiat. Res., 7, 1-12.
21. LITCHFIELD, J.T. & WILCOXON, F. (1949). A simplified method of evaluating dose-effect experiments. J. Pharmacol. Exp. Ther., 96, 99-113.
22. LÖSCHER, W. & SCHMIDT, D. (1988). Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations. Epilep. Res., 2, 145-181.
23. 1B receptor mRNA levels in rat brain. Brain Res., 722, 50-58.
24. PASINI, A., TORTORELLA, A. & GALE, K. (1996). The anticonvulsant action of fluoxetine in substantia nigra is dependent upon endogenous serotonin. Brain Res., 724, 84-88.
25. PAZOS, A. & PALACIOS, J.M. (1985). Quantitative autoradiographic mapping of serotonin receptors in the rat brain: I. Serotonin-1 receptors. Brain Res., 346, 205-230.
26. 1D receptors. Naunyn-Schmiedeberg's. Arch. Pharmacol., 356, 312-320.
27. PRZEGALINSKI, E., BARAN, L. & SIWANOWICZ, J. (1994). Role of 5-hydroxytryptamine receptor subtypes in the 1-[3-(trifluoromethyl)-phenyl] piperazine-induced increase in threshold for maximal electroconvulsions in mice. Epilepsia, 35, 889-894.
28. 1B receptor antagonist with negative intrinsic activity. Br. J. Pharmacol., 125, 202-208.
29. SHIRAGA, H., HIRAMATSU, M. & MORI, A. (1986). Convulsive activity of alpha-guanidinoglutaric acid and the possible involvement of 5-hydroxytryptamine in the alpha-guanidinoglutaric acid-induced seizure mechanism. J. Neurochem., 47, 1832-1836.
30. 1D receptor antagonist. Br. J. Pharmacol., 110, 9P.
31. STATNICK, M.A., MARINGSMITH, M.L., CLOUGH, R.W., WANG, C, DAILEY, J.W., JOBE. P.C. & BROWNING, R.A. (1996). Effect of 5,7-dihydroxytryptamine on audiogenic seizures in genetically epilepsy-prone rats. Life Sci., 59, 1763-1771.
32. TRICKLEBANK, M.D., MIDDLEMISS, D.N. & NEILL, J. (1986). Pharmacological analysis of the behavioural and thermoregulatory effects of the putative 5-HT1 receptor agonist, RU 24969, in the rat. Neuropharmacology, 25, 877-886.
33. UPTON, N., BLACKBURN, T.P., CAMPBELL, C.A., COOPER, D., EVANS, M.L., HERDON, H.J., KING, P.D., RAY, A.M., STEAN, T.O., CHAN, W.N., EVANS, J.M. & THOMPSON, M. (1997). Profile of SB-204269, a mechanistically novel anticonvulsant drug, in rat models of focal and generalized epileptic seizures. Br. J. Pharmacol., 121, 1679-1686.
34. 1B receptors in regulating generalised seizure threshold in rodents. Eur. J. Pharmacol., 359, 33-40.
35. 1B receptor. EMBO J., 10, 4017-4023.
36. WADA, Y., NAKAMURA, M., HASEGAWA, H. & YAMAGUCHI, N. (1993). Intra-hippocampal injection of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) inhibits partial and generalized seizures induced by kindling stimulation in cats. Neurosci. Lett., 159, 179-182.
37. WADA, Y., SHIRAISHI, J., NAKAMURA, M. & KOSHINO, Y. (1997). Role of serotonin receptor subtypes in the development of amygdaloid kindling in rats. Brain Res., 747, 338-342.
38. 1B receptors. Neuropharmacology, 21, S52-S60.