Synthesis, 5-HT(1A) and 5-HT(2A) receptor affinity of new 1-phenylpiperazinylpropyl derivatives of purine-2,6- and pyrrolidine-2,5-diones

Farmaco

Volumn 55, Issue 6-7, 2000, Pages 461-468

  Pawlowski, Maciej ^a   Chloń, Grazyna ^a   Obniska, Jolanta ^a   Zejc, Alfred ^a   Charakchieva Minol, Sijka ^b   Mokrosz, Maria J ^b  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^b INSTITUTE OF PHARMACOLOGY   (Poland)

Author keywords

1 Phenylpiperazinylpro pyl pyrrolidine 2,5 diones; 1 Phenylpiperazinylpropylpurine 2,6 diones; 5 HT(1A) and 5 HT(2A) receptor affinity

Indexed keywords

1,3 DIMETHYL 10 [3 (4 PHENYL 1 PIPERAZINYL)PROPYL] 2,4 DIOXO 1,3,6,7,8,9 HEXAHYDRO 10H 1,3 DIAZEPINO[2,1 F]PURINE; 1,3 DIMETHYL 7 N BUTYL 8 [3 (4 PHENYL 1 PIPERAZINYL)PROPYLAMINO]PURINE 2,6 DIONE; 1,3 DIMETHYL 8 [3 (4 PHENYL 1 PIPERAZINYL)PROPYLAMINO]PURINE 2,6 DIONE 7 ACETIC ACID ETHYL ESTER; 1,3 DIMETHYL 8 [3 (4 PHENYL 1 PIPERAZINYL)PROPYLAMINO]PURINE 2,6 DIONE 7 BUTYRIC ACID; 1,3 DIMETHYL 8 [3 (4 PHENYL 1 PIPERAZINYL)PROPYLAMINO]PURINE 2,6 DIONE 7 BUTYRIC ACID ETHYL ESTER; 1,3,7 TRIMETHYL 8 [3 (4 PHENYL 1 PIPERAZINYL)PROPYLAMINO]PURINE 2,6 DIONE; 5 CYCLOPENTANESPIRO 3 [3 (4 PHENYL 1 PIPERAZINYL)PROPYL]IMIDAZOLIDINE 2,4 DIONE; BUSPIRONE; IPSAPIRONE; N [(4 PHENYL 1 PIPERAZINYL)PROPYL] 3 (3 BROMOPHENYL)PYRROLIDINE 2,5 DIONE; N [(4 PHENYL 1 PIPERAZINYL)PROPYL] 3 (3 CHLOROPHENYL)PYRROLIDINE 2,5 DIONE; N [(4 PHENYL 1 PIPERAZINYL)PROPYL] 3 (4 BROMOPHENYL)PYRROLIDINE 2,5 DIONE; N [(4 PHENYL 1 PIPERAZINYL)PROPYL] 3 (4 FLUOROPHENYL)PYRROLIDINE 2,5 DIONE; N [(4 PHENYL 1 PIPERAZINYL)PROPYL] 3 PHENYLPYRROLIDINE 2,5 DIONE; N [(4 PHENYL 1 PIPERAZINYL)PROPYL] 3,3 DIPHENYLPYRROLIDINE 2,5 DIONE; PURINE DERIVATIVE; PYRROLIDINE DERIVATIVE; SEROTONIN 1A AGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN 2A AGONIST; SEROTONIN 2A RECEPTOR; UNCLASSIFIED DRUG; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; LIGAND; SEROTONIN 1 RECEPTOR; SEROTONIN RECEPTOR; SEROTONIN RECEPTOR AFFECTING AGENT;

ANIMAL TISSUE; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; ANIMAL; DRUG EFFECT; IN VITRO STUDY; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RADIOASSAY; SYNTHESIS; THIN LAYER CHROMATOGRAPHY; ULTRAVIOLET SPECTROPHOTOMETRY;

ANIMALS; CHROMATOGRAPHY, THIN LAYER; INDICATORS AND REAGENTS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PURINES; PYRROLIDINES; RADIOLIGAND ASSAY; RATS; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN AGENTS; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 0033625970     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(00)00069-0     Document Type: Article

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