Synthesis and structure-activity relationships of a new model of arylpiperazines. 1. 2-[[4-(o-methoxyphenyl)piperazin-1-yl]methyl]-1,3- dioxoperhydroimidazo[1,5-a]pyridine: A selective 5-HT(1A) receptor agonist

Journal of Medicinal Chemistry

Volumn 39, Issue 22, 1996, Pages 4439-4450

  López Rodríguez, María L ^a   Rosado, Ma Luisa ^a   Benhamú, Bellinda ^a   Morcillo, Ma José ^c   Sanz, Antonio M ^a   Orensanz, Luis ^b   Beneitez, Ma Eugenia ^a   Fuentes, José A ^a   Manzanares, Jorge ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b HOSPITAL RAMÓN Y CAJAL   (Spain)

^c UNIVERSIDAD NACIONAL DE EDUCACIÓN A DISTANCIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 METHOXYPHENYL) 4 (4 PHTHALIMIDOBUTYL)PIPERAZINE; 2 [[4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]METHYL] 1,3 DIOXOPERHYDROIMIDAZO[1,5 A]PYRIDINE; BUSPIRONE; PIPERAZINE DERIVATIVE; SEROTONIN AGONIST; UNCLASSIFIED DRUG;

ADRENERGIC RECEPTOR BLOCKING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DRUG SYNTHESIS; HYPOTHERMIA; LIGAND BINDING; LIPOPHILICITY; NONHUMAN; RAT; RECEPTOR AFFINITY; SEROTONIN RELEASE; SOCIAL INTERACTION; STRUCTURE ACTIVITY RELATION; TRANQUILIZING ACTIVITY;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; BEHAVIOR, ANIMAL; BODY TEMPERATURE; CEREBRAL CORTEX; KINETICS; MICE; PIPERAZINES; RACLOPRIDE; RATS; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, DOPAMINE D2; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SALICYLAMIDES; SEROTONIN AGONISTS; SOCIAL BEHAVIOR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029914712     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960416g     Document Type: Article

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