Cell Death in the Liver-All Roads Lead to JNK

Gastroenterology

Volumn 131, Issue 1, 2006, Pages 314-316

  Schwabe, Robert F ^a  

^a College of Physicians and Surgeons ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; PARACETAMOL; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR;

CELL DEATH; CELL PROLIFERATION; CELL STIMULATION; CELL TYPE; DRUG ACTIVITY; EDITORIAL; ENZYME ACTIVATION; GENETIC TRANSCRIPTION; HUMAN; INGESTION; INTOXICATION; LIVER; LIVER CELL; LIVER FAILURE; LIVER FUNCTION; LIVER INJURY; LIVER MITOCHONDRION; LIVER PARENCHYMA; LIVER REGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; SIGNAL TRANSDUCTION;

EID: 33745738684     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2006.05.029     Document Type: Editorial

References (23)

1. Lee W.M. Acute liver failure in the United States. Semin Liver Dis 23 (2003) 217-226
2. Jaeschke H., and Bajt M.L. Intracellular signaling mechanisms of acetaminophen-induced liver cell death. Toxicol Sci 89 (2006) 31-41
3. Su G.L., Gong K.Q., Fan M.H., Kelley W.M., Hsieh J., Sun J.M., Hemmila M.R., Arbabi S., Remick D.G., and Wang S.C. Lipopolysaccharide-binding protein modulates acetaminophen-induced liver injury in mice. Hepatology 41 (2005) 187-195
4. Gunawan B.K., Lu Z.-X., Han D., Hanawa N., Gaarde W.A., and Kaplowitz N. c-Jun-N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity. Gastroenterology 131 (2006) 165-178
5. Schwabe R.F., and Brenner D.A. Mechanisms of liver injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. Am J Physiol Gastrointest Liver Physiol 290 (2006) G583-G589
6. Schwabe R.F., Uchinami H., Qian T., Bennett B.L., Lemasters J.J., and Brenner D.A. Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes. FASEB J 18 (2004) 720-722
7. Chang L., Kamata H., Solinas G., Luo J.L., Maeda S., Venuprasad K., Liu Y.C., and Karin M. The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Cell 124 (2006) 601-613
8. Fan M., Goodwin M., Vu T., Brantley-Finley C., Gaarde W.A., and Chambers T.C. Vinblastine-induced phosphorylation of Bcl-2 and Bcl-XL is mediated by JNK and occurs in parallel with inactivation of the Raf-1/MEK/ERK cascade. J Biol Chem 275 (2000) 29980-29985
9. Uehara T., Bennett B., Sakata S.T., Satoh Y., Bilter G.K., Westwick J.K., and Brenner D.A. JNK mediates hepatic ischemia reperfusion injury. J Hepatol 42 (2005) 850-859
10. Deng Y., Ren X., Yang L., Lin Y., and Wu X. A JNK-dependent pathway is required or TNFalpha-induced apoptosis. Cell 115 (2003) 61-70
11. Kon K., Kim J.S., Jaeschke H., and Lemasters J.J. Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes. Hepatology 40 (2004) 1170-1179
12. Beales D., and McLean A.E. Protection in the late stages of paracetamol-induced liver cell injury with fructose, cyslosporin A and trifluoperazine. Toxicology 107 (1996) 201-208
13. Kamata H., Honda S., Maeda S., Chang L., Hirata H., and Karin M. Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 120 (2005) 649-661
14. Trautwein C., Rakemann T., Brenner D.A., Streetz K., Licato L., Manns M.P., and Tiegs G. Concanavalin A-induced liver cell damage. activation of intracellular pathways triggered by tumor necrosis factor in mice. Gastroenterology 114 (1998) 1035-1045
15. Matsumaru K., Ji C., and Kaplowitz N. Mechanisms for sensitization to TNF-induced apoptosis by acute glutathione depletion in murine hepatocytes. Hepatology 37 (2003) 1425-1434
16. Bradham C.A., Stachlewitz R.F., Gao W., Qian T., Jayadev S., Jenkins G., Hannun Y., Lemasters J.J., Thurman R.G., and Brenner D.A. Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases. Hepatology 25 (1997) 1128-1135
17. Graf D., Kurz A.K., Fischer R., Reinehr R., and Haussinger D. Taurolithocholic acid-3 sulfate induces CD95 trafficking and apoptosis in a c-Jun N-terminal kinase-dependent manner. Gastroenterology 122 (2002) 1411-1427
18. Maeda S., Chang L., Li Z.W., Luo J.L., Leffert H., and Karin M. IKKbeta is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFalpha. Immunity 19 (2003) 725-737
19. Uehara T., Xi Peng X., Bennett B., Satoh Y., Friedman G., Currin R., Brenner D.A., and Lemasters J. c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation. Transplantation 78 (2004) 324-332
20. Wang Y., Singh R., Lefkowitch J.H., Rigoli R.M., and Czaja M.J. TNF-induced toxic liver injury results from JNK2-dependent activation of caspase-8 and the mitochondrial death pathway. J Biol Chem 281 (2006) 15258-15267
21. Sabapathy K., Hochedlinger K., Nam S.Y., Bauer A., Karin M., and Wagner E.F. Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation. Mol Cell 15 (2004) 713-725
22. Liu J., Minemoto Y., and Lin A. c-Jun N-terminal protein kinase 1 (JNK1), but not JNK2, is essential for tumor necrosis factor alpha-induced c-Jun kinase activation and apoptosis. Mol Cell Biol 24 (2004) 10844-10856
23. Schwabe R.F., Bradham C.A., Uehara T., Hatano E., Bennett B.L., Schoonhoven R., and Brenner D.A. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Hepatology 37 (2003) 824-832