Pharmacokinetic-pharmacodynamic (PK-PD) modeling of cardiovascular effects of metoprolol in spontaneously hypertensive rats: A microdialysis study

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 373, Issue 4, 2006, Pages 310-318

  Höcht, Christian ^a   Di Verniero, Carla ^a   Opezzo, Javier A W ^a   Bramuglia, Guillermo F ^a   Taira, Carlos A ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Blood pressure; Chronotropic effect; Metoprolol; Microdialysis; Pharmacokinetic pharmacodynamic modeling; Spontaneously hypertension

Indexed keywords

BETA ADRENERGIC RECEPTOR; METOPROLOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BLOOD PRESSURE REGULATION; BRADYCARDIA; CHRONOTROPISM; CORRELATION ANALYSIS; DIALYSATE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DIALYSABILITY; DRUG EFFECT; DRUG EFFICACY; DRUG HALF LIFE; HYPERTENSION; IC 50; MALE; MICRODIALYSIS; NONHUMAN; RAT; RAT STRAIN; SPONTANEOUSLY HYPERTENSIVE RAT;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; HEART RATE; HYPERTENSION; MALE; METOPROLOL; MICRODIALYSIS; MODELS, BIOLOGICAL; RATS; RATS, INBRED SHR; RATS, INBRED WKY;

EID: 33745726245     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-006-0078-x     Document Type: Article

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