Pharmacokinetic-pharmacodynamic modelling of metoprolol stereoisomers in spontaneously hypertensive rat

Acta Pharmacologica Sinica

Volumn 18, Issue 2, 1997, Pages 104-108

  Yin, Xiao Xing ^a,b   Zhang, Yin Di ^a   Luo, Jian Ping ^a   Huang, Xiao Ping ^a   Shen, Jian Ping ^a   Ding, Yong ^a   Huang, Da Kuang ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b XUZHOU MEDICAL UNIVERSITY   (China)

Author keywords

inbred SHR rats; metoprolol; pharmacodynamics; pharmacokinetics; stereoisomers

Indexed keywords

METOPROLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; CARDIOVASCULAR RESPONSE; COMPARTMENT MODEL; CONTROLLED STUDY; DRUG BLOOD LEVEL; HEART MUSCLE CONTRACTILITY; HEART RATE; INTRAGASTRIC DRUG ADMINISTRATION; MALE; NONHUMAN; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SPONTANEOUSLY HYPERTENSIVE RAT; STEREOISOMERISM; ANIMAL; AREA UNDER THE CURVE; COMPARATIVE STUDY; DRUG EFFECT; HYPERTENSION; METABOLISM; PATHOPHYSIOLOGY;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; AREA UNDER CURVE; BLOOD PRESSURE; HEART RATE; HYPERTENSION; MALE; METOPROLOL; RATS; RATS, INBRED SHR; STEREOISOMERISM;

EID: 0031082516     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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